Limited Competition for the Continuation of the NIDDK Gastroparesis Consortium (U01) | Apply Online

Opportunity Summary:

This funding opportunity, RFA-DK-10-502, is a limited competition run by the National Institutes of Health (NIH) through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It is designed specifically to continue the work of the existing NIDDK Gastroparesis Consortium rather than open the competition to entirely new groups. The key idea is continuity: the only organizations meant to apply are the clinical sites and the Data Coordinating Center (DCC) that already participated in the consortium and therefore still have direct access to the established cohort of gastroparesis patients and the associated data from the consortium's prospective observational study. Because the scientific value of this program depends heavily on long-term follow-up and consistent data collection, the announcement emphasizes maintaining the infrastructure and relationships already in place.

The purpose of the grant is threefold. First, it aims to keep following a group of patients who are described as well characterized and highly motivated, which signals that the cohort has already been deeply phenotyped and is likely to remain engaged in research activities, making them especially valuable for long-term outcomes research. Second, it supports the continuation of ongoing clinical trials that were already initiated under the consortium, which helps prevent the loss of momentum, data gaps, or discontinuation costs that can occur when multicenter studies lose funding. Third, it is meant to serve as a platform for ancillary studies, meaning add-on or companion projects that can leverage the existing patient network, specimens, and data systems to answer additional questions efficiently without rebuilding a study population from scratch.

In terms of how the awards will be managed, the mechanism is a U01 cooperative agreement. That matters because cooperative agreements typically involve a more active partnership between NIH program staff and the awardees than a standard research project grant. In practice, that usually means NIH expects to have substantial involvement in coordinating goals, tracking progress, and ensuring the consortium functions as an integrated network rather than as separate independent projects. The activity category is listed under Food and Nutrition/Health and the CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), which aligns with gastroparesis being a digestive disorder within NIDDK's mission.

Funding levels and structure are clearly defined. NIDDK planned to commit about $4,000,000 in fiscal year 2011 to support up to six participating clinical centers plus one Data Coordinating Center. The listed award ceiling is $300,000, which typically signals a cap on direct costs per award per year or per budget period (the specific interpretation would be confirmed in the full announcement), but the overall intent is to distribute the approximately $4 million across the clinical sites and the DCC to keep the consortium operational and productive. There is no cost sharing or matching requirement, reducing barriers for eligible institutions.

Eligibility is limited to certain applicant types, specifically private institutions of higher education and public/state-controlled institutions of higher education, but the narrative makes clear that, beyond institutional eligibility, it is functionally restricted to those already in the consortium because they alone have the continuing access to the cohort and data resources that the project depends on. This is why it is described as a limited competition: it is competitive among a small, predefined set of existing participants rather than open to the broader research community.

Key dates show that the opportunity was posted on May 17, 2010, with an original and current closing date of July 19, 2010, and it was archived on August 19, 2010. The announcement includes an additional information link hosted on the NIH grants site, and it provides contact points through the NIH Office of Extramural Research (OER) webmaster for applicants who encounter technical issues accessing the announcement or linking to it.

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