Limited Competition International epidemiology Databases to Evaluate AIDS (IeDEA) (U01) | Apply Online

Opportunity Summary:

The grant opportunity titled "Limited Competition International epidemiology Databases to Evaluate AIDS (IeDEA) (U01)" (Funding Opportunity Number RFA-AI-15-017) is a National Institutes of Health (NIH) cooperative agreement designed to continue the long-running IeDEA Program. IeDEA is an international research infrastructure effort focused on building and maintaining large, harmonized clinical and research databases that can be used to answer major real-world questions about HIV/AIDS. Rather than funding isolated studies, this program supports regional data centers that pull together data from multiple cohorts and clinical sites, creating a powerful platform for large-scale epidemiologic analyses across different populations and health systems.

At its core, the program supports seven regional data centers, each responsible for coordinating, curating, and leveraging data from its network of contributing sites. These centers combine routinely collected clinical information and research-grade data so investigators can study outcomes and trends that are difficult to capture in smaller datasets. The scientific scope is broad but clearly centered on HIV: it includes HIV/AIDS treatment and care outcomes, and it explicitly extends to key comorbidities and complications that commonly affect people living with HIV. The FOA highlights tuberculosis and hepatitis as major infectious disease co-conditions, cancer epidemiology and cancer-related outcomes, and neurologic as well as mental health complications in both adults and children. In practice, that means the supported work can range from evaluating antiretroviral therapy outcomes and long-term survival to understanding how HIV interacts with TB coinfection patterns, viral hepatitis progression, cancer risks, and neurocognitive or psychiatric burdens across diverse settings.

The funding mechanism is a U01 cooperative agreement, which typically means NIH expects to have substantial programmatic involvement compared with a standard research project grant. This kind of structure is often used when the goal is a coordinated, multi-site program with shared standards, common data models, and collaboration across awardees, rather than a set of independent projects. The activity categories listed for the opportunity reflect the cross-cutting nature of IeDEA, spanning education/health/income security and social services, and aligning with multiple CFDA areas including allergy and infectious diseases, microbiology, child health, mental health, drug abuse and addiction research, and several cancer research categories (prevention through control). That mix signals that the databases are expected to support questions at the intersection of infectious disease, chronic disease, behavioral health, and pediatric and adult care.

This was a limited competition announcement, meaning it was not open to new applicants broadly. Eligibility was restricted to renewal applications from the existing IeDEA Regional Data Centers only. The FOA lists the specific organizations eligible to apply as renewals: Foundation for AIDS Research (New York, NY), Indiana University (Indianapolis, IN), Johns Hopkins University (Baltimore, MD), ADERA (France), Vanderbilt University (Nashville, TN), University of Bern (Switzerland), and Albert Einstein College of Medicine (New York, NY). While the general eligible applicant types include private institutions of higher education and public/state-controlled institutions of higher education, the practical eligibility constraint is the renewal-only limitation to those named centers.

NIH anticipated making seven awards, matching the seven regional data center structure of the program. The opportunity did not require cost sharing or matching. Key dates show the announcement was posted and created on April 10, 2015, with an original and current closing date of July 17, 2015, and an archive date of August 17, 2015, indicating the announcement is no longer active. The issuing agency is NIH, and the full announcement was made available through the NIH grants guide at the link provided in the notice.

Overall, this FOA was aimed at sustaining a global, regionally organized data infrastructure for HIV/AIDS epidemiology and outcomes research. By continuing to fund the existing regional data centers, NIH sought to preserve and strengthen the ability of the research community to conduct large, multi-country analyses on HIV and its major coinfections and complications, including TB, hepatitis, cancer, and neurologic and mental health conditions, across both adult and pediatric populations.

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Previous opportunity: Susan Harwood Training Grant, FY 2015, (Targeted Topics)

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