Opportunity Information: Apply for RFA MH 14 110
Apply for RFA MH 14 110
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Mental Health Research Network II (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on May 8, 2013 and posted on May 8, 2013.
- Applicants must submit their applications by Jul 22, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Limited Competition Mental Health Research Network II (U19) opportunity (Funding Opportunity Number RFA-MH-14-110) was a National Institutes of Health cooperative agreement designed to continue and expand the Mental Health Research Network (MHRN). The MHRN is a consortium-based research resource embedded within several non-profit, integrated health care delivery systems. Its core value is that it connects large, real-world clinical populations with standardized data and shared research infrastructure, making it possible to run large effectiveness studies and evaluate mental health care as it is delivered in everyday practice rather than only in tightly controlled academic settings.
The FOA builds on what the MHRN was originally created to do: show that multiple health systems can reliably identify, recruit, and enroll very large patient populations into effectiveness trials; harmonize electronic medical record (EMR) data so that information from different systems can be analyzed together; pool multi-site data for shared analyses; and develop the ability to collect and store biologic materials when needed. In other words, it supports the kind of large-scale infrastructure that lets researchers ask practical questions about treatment outcomes, safety, utilization, and implementation across broad and diverse patient groups.
This second phase (MHRN II) was intended as a targeted expansion rather than a brand-new build. The announcement highlights three main areas the network was expected to strengthen. First, the network was to develop stronger capacity to conduct trials that involve pharmacotherapy, meaning studies where medication treatment is a central part of the research design and where the systems need robust procedures for prescribing, monitoring, safety oversight, and outcome measurement at scale. Second, the network was to develop procedures and operational capability for deploying large-scale mental health information technology interventions, such as system-wide digital tools, clinical decision support, patient-facing platforms, or other IT-enabled approaches that can be rolled out across multiple health systems in a consistent, study-ready way. Third, the award was to support a "signature project" intended to have large population impact in a high-priority area for the field, signaling that the network was expected not only to maintain infrastructure but also to demonstrate its power through at least one major, high-visibility research effort capable of influencing care for large numbers of patients.
Beyond these expansion goals, the FOA emphasizes the MHRN's ongoing role as a collaborative platform. The network was expected to maintain and refine processes that allow outside investigators to work with the consortium on relevant studies, which is an important feature because it turns the network into a national resource rather than a closed internal project. Another continued expectation was active use of the Virtual Data Warehouse (VDW), a shared data model approach used in many integrated delivery system research collaborations. The FOA specifically points to using the VDW for studies such as policy impact analyses, examination of practice variation across settings, and "signal detection" work, which commonly refers to identifying potential safety issues, unexpected outcomes, or emerging patterns in large datasets that warrant further investigation. Finally, the announcement underscores dissemination: findings were expected to be effectively communicated and translated back into the large health care delivery systems connected to the MHRN so that results can influence clinical operations and real-world practice.
Administratively, this was a discretionary funding opportunity using a cooperative agreement mechanism (U19), meaning NIH would expect substantial involvement in coordination, oversight, or partnership rather than a hands-off grant. The activity category was health, and the program fell under CFDA 93.242 (Mental Health Research Grants). The announcement anticipated a single award with an estimated total funding level of $2,000,000, and it did not require cost sharing or matching. The FOA was posted May 8, 2013, with an original and current closing date of July 22, 2013, and an archive date of August 22, 2013.
Eligibility was limited and described as "Limited Competition," with applicants falling under the "Others (see text)" category, which typically indicates that only certain organizations (often existing network members or otherwise specified entities) were eligible under the full FOA terms. Foreign institutions were explicitly not eligible, and foreign components, as defined by the NIH Grants Policy Statement, were not allowed. For applicants or readers who needed the full details, NIH provided the full FOA link (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-14-110.html) and standard NIH Office of Extramural Research contact support for access or technical issues.
FAQs: Limited Competition Mental Health Research Network II (U19) - RFA-MH-14-110
What is this funding opportunity?
This opportunity, titled "Limited Competition Mental Health Research Network II (U19)" (Funding Opportunity Number RFA-MH-14-110), was a National Institutes of Health (NIH) cooperative agreement intended to continue and expand the Mental Health Research Network (MHRN).
What is the Mental Health Research Network (MHRN)?
The MHRN is a consortium-based research resource embedded within several non-profit, integrated health care delivery systems. Its core value is connecting large, real-world clinical populations with standardized data and shared research infrastructure so researchers can run large effectiveness studies and evaluate mental health care as it is delivered in everyday practice.
What kind of research does the MHRN enable?
The MHRN is designed to support large-scale effectiveness research in real-world settings, including studies focused on treatment outcomes, safety, utilization, and implementation across broad and diverse patient groups.
What does it mean that this is the second phase (MHRN II)?
MHRN II was described as a targeted expansion rather than a brand-new build. It builds on the original network goals and strengthens specific capacities within the existing consortium-based infrastructure.
What were the main infrastructure capabilities the FOA builds on?
The FOA builds on the MHRN's ability to: (1) reliably identify, recruit, and enroll very large patient populations into effectiveness trials across multiple health systems; (2) harmonize electronic medical record (EMR) data so data from different systems can be analyzed together; (3) pool multi-site data for shared analyses; and (4) develop the ability to collect and store biologic materials when needed.
What were the three main expansion areas expected under MHRN II?
The announcement highlights three areas: (1) stronger capacity to conduct pharmacotherapy trials (medication-focused studies requiring robust prescribing, monitoring, safety oversight, and outcome measurement at scale); (2) procedures and operational capability for deploying large-scale mental health information technology interventions across multiple systems in a consistent, study-ready way; and (3) support for a "signature project" intended to have large population impact in a high-priority area.
What is meant by building stronger capacity for pharmacotherapy trials?
It refers to improving the network's ability to run trials where medication treatment is central to the research design, including the operational procedures for prescribing, monitoring, safety oversight, and measuring outcomes at scale across participating health systems.
What are examples of the mental health information technology interventions described?
The FOA describes large-scale interventions such as system-wide digital tools, clinical decision support, patient-facing platforms, or other IT-enabled approaches that can be rolled out consistently across multiple health systems.
What is the "signature project" requirement or expectation?
The FOA indicates the award would support a signature project designed to demonstrate the network's capabilities through a major, high-visibility research effort with the potential to influence care for large numbers of patients in a high-priority area.
Was the network expected to support collaboration with outside investigators?
Yes. The FOA emphasizes maintaining and refining processes that allow outside investigators to work with the consortium on relevant studies, positioning the network as a national resource rather than a closed internal project.
What is the Virtual Data Warehouse (VDW) and how was it expected to be used?
The FOA references active use of the Virtual Data Warehouse (VDW), a shared data model approach used in integrated delivery system research collaborations. It was pointed to as a resource for studies including policy impact analyses, examination of practice variation across settings, and "signal detection" work.
What does "signal detection" mean in the context of this FOA?
In this context, "signal detection" commonly refers to identifying potential safety issues, unexpected outcomes, or emerging patterns in large datasets that warrant further investigation.
What did the FOA say about dissemination of findings?
The FOA underscores that findings were expected to be effectively communicated and translated back into the large health care delivery systems connected to the MHRN so results can influence clinical operations and real-world practice.
What type of award mechanism was used?
This was a cooperative agreement (U19). The FOA describes it as involving substantial NIH involvement in coordination, oversight, or partnership rather than a fully hands-off grant.
Which agency and program area funded this opportunity?
The opportunity was under the National Institutes of Health (NIH). The activity category was health, and the program fell under CFDA 93.242 (Mental Health Research Grants).
How many awards were anticipated and what was the estimated funding level?
The announcement anticipated a single award, with an estimated total funding level of $2,000,000.
Was cost sharing or matching required?
No. The FOA stated that cost sharing or matching was not required.
What were the key dates for this FOA?
The FOA was posted May 8, 2013. The original and current closing date was July 22, 2013. The archive date was August 22, 2013.
Was this an open competition?
No. It was labeled a "Limited Competition" opportunity, and eligibility was described under "Others (see text)," which typically indicates only certain organizations (often existing network members or otherwise specified entities under the full FOA terms) could apply.
Are foreign institutions eligible to apply?
No. Foreign institutions were explicitly not eligible.
Are foreign components allowed under this award?
No. Foreign components, as defined by the NIH Grants Policy Statement, were not allowed.
Where can applicants find the full official FOA text?
The FOA link provided was: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-14-110.html.
What support was mentioned for access or technical issues related to the FOA?
NIH provided standard NIH Office of Extramural Research contact support for access or technical issues.
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