Opportunity Information: Apply for RFA MH 16 230
Apply for RFA MH 16 230
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Multi scale Molecular Profiling of Brains from Psychiatric Cohorts (Collaborative R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Sep 1, 2015 and posted on Sep 1, 2015.
- Applicants must submit their applications by Nov 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Organizations) This FOA is limited to the awardees of the PsychENCODE Consortium and Common Mind Consortium
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity titled "Limited Competition Multi scale Molecular Profiling of Brains from Psychiatric Cohorts (Collaborative R01)" (Funding Opportunity Number RFA-MH-16-230) is a National Institutes of Health (NIH) discretionary research grant focused on mental health. Its core aim is to fund projects that can map, in a comprehensive and integrated way, the molecular changes associated with psychiatric disorders across multiple brain regions. The announcement emphasizes "multi scale" and "multi modal" molecular profiling, meaning applicants are expected to combine more than one type of molecular measurement (for example, genomic, transcriptomic, epigenomic, and other molecular layers) and to do so across different spatial scales and brain areas rather than treating the brain as a single uniform tissue. The scientific motivation is to move beyond isolated findings and instead build an organized, region-by-region molecular landscape that can support more realistic molecular models of psychiatric illness.
A defining feature of this FOA is that it is a limited competition tied to existing large-scale brain resources. The work is meant to leverage established, high-quality, and phenotypically well-characterized postmortem human brain collections that already include brains from individuals diagnosed with psychiatric disorders. Rather than funding new tissue collection efforts, the announcement is structured to capitalize on cohorts and infrastructure already assembled by two major collaborative programs: the CommonMind Consortium and the PsychENCODE Consortium. In practical terms, the eligible applicant pool is restricted to awardees/investigators from those consortia specifically because they already have the necessary access, consent frameworks, data context, and sample quality controls needed for rigorous, large-scale molecular profiling. While the eligibility language allows non-U.S. (foreign) organizations, that flexibility still sits inside the main restriction that applicants must be awardees of PsychENCODE and/or CommonMind.
The end goal is explicitly model-building: developing molecular models of psychiatric disorders grounded in coordinated, multi-omic evidence across brain regions. That implies projects should not only generate datasets, but also integrate them in ways that clarify disease-associated molecular pathways, regional specificity, and potentially shared versus distinct molecular signatures across diagnoses or clinical subtypes captured by the underlying cohorts. Because these collections are described as "phenotypically well characterized," the FOA signals an expectation that molecular findings will be interpretable in relation to clinical or demographic variables already annotated in the cohorts (such as diagnosis, age, sex, illness course, treatment exposure when available, and other relevant clinical descriptors), enabling more informative disease modeling than would be possible with poorly characterized samples.
From an administrative and funding standpoint, this is an NIH R01 mechanism framed as a collaborative effort, with an anticipated six awards and an estimated total funding level of $3,000,000. It falls under CFDA 93.242 (Mental Health Research Grants). There is no cost sharing or matching requirement. The opportunity was posted on September 1, 2015, with an original and final application due date of November 3, 2015, and it was archived on December 4, 2015. The agency listed is NIH, and the activity category is Health, consistent with NIMH-oriented objectives implied by the "MH" designation in the FOA number.
Overall, the opportunity is best understood as a targeted investment to accelerate high-resolution, integrative molecular characterization of psychiatric illness in the human brain by mobilizing two existing, well-resourced consortia. It is not a broad open call; it is a directed competition meant to produce harmonized, consortium-linked datasets and analyses that can support robust molecular models of psychiatric disorders, grounded in multi-modal profiling across multiple brain regions using established postmortem cohorts.
FAQs: Limited Competition Multi scale Molecular Profiling of Brains from Psychiatric Cohorts (Collaborative R01) - RFA-MH-16-230
What is the official title and funding opportunity number for this grant?
The opportunity is titled "Limited Competition Multi scale Molecular Profiling of Brains from Psychiatric Cohorts (Collaborative R01)" and the Funding Opportunity Number (FOA) is RFA-MH-16-230.
Which agency is offering this grant?
The grant is offered by the National Institutes of Health (NIH).
What type of grant mechanism is this?
This opportunity uses the NIH R01 mechanism and is described as a collaborative R01 effort.
What is the main goal of this funding opportunity?
The core goal is to support projects that map, in a comprehensive and integrated way, the molecular changes associated with psychiatric disorders across multiple brain regions. The intent is to produce an organized, region-by-region molecular landscape that can support more realistic molecular models of psychiatric illness.
What does "multi scale" and "multi modal" molecular profiling mean in this announcement?
"Multi scale" and "multi modal" indicates that applicants are expected to combine more than one type of molecular measurement (for example, genomic, transcriptomic, epigenomic, and other molecular layers) and to do so across different spatial scales and brain areas, rather than treating the brain as a single uniform tissue.
Does this FOA emphasize data generation, data integration, or both?
Both. The end goal is model-building, so projects are expected not only to generate molecular datasets, but also to integrate them to clarify disease-associated molecular pathways, regional specificity, and shared versus distinct molecular signatures across diagnoses or clinical subtypes represented in the cohorts.
What kinds of samples or resources is the work expected to use?
The work is intended to leverage established, high-quality, phenotypically well-characterized postmortem human brain collections that already include brains from individuals diagnosed with psychiatric disorders.
Is this grant intended to fund new tissue collection efforts?
No. The announcement is structured to capitalize on cohorts and infrastructure already assembled, rather than funding new tissue collection efforts.
Which existing programs or consortia are central to this limited competition?
This limited competition is tied to two major collaborative programs: the CommonMind Consortium and the PsychENCODE Consortium.
Who is eligible to apply?
Eligibility is restricted to awardees/investigators from the PsychENCODE and/or CommonMind consortia, because they already have the necessary access, consent frameworks, data context, and sample quality controls needed for rigorous, large-scale molecular profiling.
Are non-U.S. (foreign) organizations allowed to apply?
The eligibility language allows non-U.S. (foreign) organizations, but that flexibility still sits within the main restriction that applicants must be awardees of PsychENCODE and/or CommonMind.
Why is this competition limited rather than broadly open?
It is limited because the FOA is designed to mobilize existing, well-resourced consortia with established cohorts, access, consent frameworks, and quality controls. The goal is to accelerate large-scale, rigorous molecular profiling using curated postmortem brain resources rather than building new collections from scratch.
What kinds of outcomes is NIH trying to enable through this FOA?
The FOA aims to accelerate high-resolution, integrative molecular characterization of psychiatric illness in the human brain by producing harmonized, consortium-linked datasets and analyses. The intended outcome is the development of molecular models of psychiatric disorders grounded in coordinated multi-omic evidence across brain regions.
How does phenotypic characterization factor into the expectations for this work?
Because the brain collections are described as "phenotypically well characterized," the FOA signals an expectation that molecular findings will be interpretable in relation to clinical or demographic variables already annotated in the cohorts (such as diagnosis, age, sex, illness course, and treatment exposure when available), enabling more informative disease modeling.
How many awards were anticipated under this opportunity?
The FOA anticipated approximately six awards.
What was the estimated total funding level for this opportunity?
The estimated total funding level was $3,000,000.
Is there a cost sharing or matching requirement?
No. There is no cost sharing or matching requirement stated for this opportunity.
What is the CFDA number associated with this program?
The CFDA number is 93.242 (Mental Health Research Grants).
What is the activity category for this opportunity?
The activity category is Health.
When was this funding opportunity posted, and what were the application due dates?
The opportunity was posted on September 1, 2015. The original and final application due date was November 3, 2015.
Is this opportunity still open?
No. The opportunity was archived on December 4, 2015.
What does "Collaborative R01" imply in the context provided?
Within the information provided, "Collaborative R01" indicates an R01 research project structured as a collaborative effort, consistent with the consortium-linked, harmonized, and integrated approach emphasized throughout the announcement.
Is this a broad call for any psychiatric molecular profiling project?
No. It is a targeted, directed competition meant to leverage two existing consortia and their postmortem cohorts to produce integrated, multi-modal profiling across multiple brain regions and support robust molecular models of psychiatric disorders.
Browse more opportunities from the same category: Health
Next opportunity: Time Varying Nuclear Decay
Previous opportunity: Limited Competition Multi scale Molecular Profiling of Brains from Psychiatric Cohorts (R01)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA MH 16 230
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA MH 16 230) also looked into and applied for these:
| Funding Opportunity |
|---|
| Service Area Competition Apply for HRSA 16 006 Funding Number: HRSA 16 006 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| R40 MCH Research (MCHR) Apply for HRSA 16 032 Funding Number: HRSA 16 032 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Occupational Safety and Health Education and Research Centers (42) Apply for PAR 15 303 Funding Number: PAR 15 303 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| R40 MCH Secondary Data Analysis Studies (SDAS) Apply for HRSA 16 029 Funding Number: HRSA 16 029 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| DELTA FOCUS (Domestic Violence Prevention Enhancement and Leadership Through Alliances, Focusing on Outcomes for Communities United with States) Apply for CDC RFA CE13 130204CONT16 Funding Number: CDC RFA CE13 130204CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| NHLBI Career Transition Award for Intramural Fellows (K22) Apply for PAR 15 341 Funding Number: PAR 15 341 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| University Technical Assistance Projects Aimed at Expanding the Delivery of HIV and AIDS Treatment and Care, Strengthening Systems and Improving the Quality of Care in the Republic of South Africa under PEPFAR Apply for CDC RFA PS07 719 Funding Number: CDC RFA PS07 719 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,000,000 |
| DoD HIV/AIDS PREVENTION CARE AND TREATMENT PROGRAM Apply for DHAPPBAA07001 Funding Number: DHAPPBAA07001 Agency: Naval Supply Systems Command Category: Health Funding Amount: Case Dependent |
| DRAFT Malaria Communities Program RFA FY08 DRAFT Apply for TBD Funding Number: TBD Agency: Agency for International Development Category: Health Funding Amount: Case Dependent |
| SSA Work Incentives Planning and Assistance Projects Apply for SSA OAG 08 1 Funding Number: SSA OAG 08 1 Agency: ODISP OESP Category: Health Funding Amount: $249,999 |
| Malaria Communities Program FY08 Request for Applications (MCP RFA) Apply for USAID M OAA GH 08 147 Funding Number: USAID M OAA GH 08 147 Agency: Agency for International Development Category: Health Funding Amount: $1,500,000 |
| CSHGP Draft RFA for Comments Only Apply for TBD1 Funding Number: TBD1 Agency: Agency for International Development Category: Health Funding Amount: $1,500,000 |
| Care Services for HIV Infected Orphans and Vulnerable Children (OVC) in Ethiopia Apply for APS 663 08 004 Funding Number: APS 663 08 004 Agency: Ethiopia USAID Addis Ababa Category: Health Funding Amount: $6,000,000 |
| State Health Insurance Assistance Program Apply for HHS 2008 CMS CONT SHIP Funding Number: HHS 2008 CMS CONT SHIP Agency: Centers for Medicare Medicaid Services Category: Health Funding Amount: $2,000,000 |
| FY 2008 Child Survival and Health Grants Progrma (CSHGP) Apply for USAID M OAA GH 08 252 Funding Number: USAID M OAA GH 08 252 Agency: Agency for International Development Category: Health Funding Amount: $1,600,000 |
| Inter Agency APS Prevention for at Risk Populations in High Prevalence Urban Areas in Ethiopia Apply for APS 663 08 007 Funding Number: APS 663 08 007 Agency: Ethiopia USAID Addis Ababa Category: Health Funding Amount: $2,000,000 |
| Defense Health Program for prevention, care and treatment of HIV/AIDS in foreign militaries Apply for DHAPPBAA07 002 Funding Number: DHAPPBAA07 002 Agency: Naval Supply Systems Command Category: Health Funding Amount: Case Dependent |
| Family Planning/Maternal, Newborn and Child Health Program Apply for USAID ETHIOPIA 663 A 08 006 RFA Funding Number: USAID ETHIOPIA 663 A 08 006 RFA Agency: Ethiopia USAID Addis Ababa Category: Health Funding Amount: $50,000,000 |
| Program Research for Strengthening Services (PROGRESS) Apply for M OAA GH POP 08 176 Funding Number: M OAA GH POP 08 176 Agency: Agency for International Development Category: Health Funding Amount: $50,000,000 |
| DRAFT RFA Maternal and Child Health Integrated Program Apply for USAID M OAA GH 08 473 Funding Number: USAID M OAA GH 08 473 Agency: Agency for International Development Category: Health Funding Amount: $600,000,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA MH 16 230", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.