Opportunity Information: Apply for PAR 14 319
Apply for PAR 14 319
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition NIGMS National Centers for Systems Biology (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 12, 2014 and posted on Aug 12, 2014.
- Applicants must submit their applications by Oct 23, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Small businesses State governments City or township governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Special district governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Limited Competition NIGMS National Centers for Systems Biology (P50) funding opportunity (PAR-14-319) is a National Institutes of Health (NIH) discretionary grant program run through the National Institute of General Medical Sciences (NIGMS). It is designed specifically to continue supporting the existing NIGMS National Centers for Systems Biology through renewal applications only, meaning it is not an open competition for brand-new centers. The overarching purpose is to sustain and advance established centers that are already carrying out systems biology efforts aligned with the NIGMS mission, with an emphasis on ambitious, systems-level investigations of biomedical phenomena.
The program’s central focus is systems biology, broadly understood as studying biological questions by integrating components of complex systems rather than looking at isolated parts in isolation. In practice, the supported centers are expected to pursue pioneering research that leverages interdisciplinary approaches, often bringing together experimental biology, quantitative methods, computational modeling, and data-driven analysis to understand how biological systems behave and respond across scales. Alongside research, the opportunity explicitly highlights research training and outreach as core components, signaling that a competitive renewal would typically maintain a strong environment for developing scientists and for sharing knowledge, tools, and approaches with broader communities, consistent with the “center” model of coordinated, multi-project programs.
In terms of award structure and finances, this opportunity uses the NIH P50 activity code, which generally supports specialized center grants that can combine multiple integrated projects and shared resources under a unified scientific theme. The listed award ceiling is $2,000,000, and there is no cost sharing or matching requirement, which is typical for many NIH research grant mechanisms. The funding activity category is Health, and it is associated with CFDA number 93.859 (Biomedical Research and Research Training), reflecting the combined expectations of research productivity and workforce development.
Eligibility is the defining feature of this announcement: it is limited competition, restricted to renewals of existing National Centers for Systems Biology awards funded by NIGMS. While the eligibility section lists many organizational types that can generally apply for federal assistance (including higher education institutions, nonprofits, state and local governments, tribal governments and organizations, and certain for-profit entities), the practical reality is that only organizations already holding the relevant NIGMS centers awards would be able to submit under this particular announcement. The notice also states that non-U.S. (foreign) institutions are not eligible to apply directly and that non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined by NIH policy are allowable, which typically means a U.S.-led application may include a justified foreign component when it is essential to the project.
Key administrative details include the posting and creation date of August 12, 2014, with an original and current closing date of October 23, 2015, and an archive date of November 23, 2015, indicating the opportunity is no longer active. Applicants and institutional officials looking for the full announcement were directed to the NIH Grants Guide link, and technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact. Overall, this program announcement was aimed at maintaining continuity and momentum for a small set of established NIGMS systems biology centers, supporting integrated research programs that also train researchers and extend impact through outreach, tool dissemination, or community-facing activities tied to systems-level biomedical science.
FAQs: Limited Competition NIGMS National Centers for Systems Biology (P50) (PAR-14-319)
What is the Limited Competition NIGMS National Centers for Systems Biology (P50) opportunity (PAR-14-319)?
This is a National Institutes of Health (NIH) discretionary grant opportunity administered by the National Institute of General Medical Sciences (NIGMS). It uses the NIH P50 specialized center grant mechanism and is specifically intended to support NIGMS National Centers for Systems Biology through renewal applications only.
Who runs and funds this program?
The program is run through NIH, specifically the National Institute of General Medical Sciences (NIGMS), as part of NIH discretionary grant programming.
Is this an open competition for new centers?
No. This is a limited competition and is restricted to renewal applications from existing NIGMS National Centers for Systems Biology. It is not designed to fund brand-new centers that do not already hold the relevant NIGMS center award.
What is the main purpose of the program?
The purpose is to sustain and advance established NIGMS-funded systems biology centers that are already conducting systems-level research aligned with the NIGMS mission, with an emphasis on ambitious investigations of biomedical phenomena at the systems level.
What does "systems biology" mean in the context of this program?
Systems biology is described broadly as studying biological questions by integrating components of complex systems rather than examining isolated parts. Supported centers are expected to pursue interdisciplinary, systems-level investigations that can include experimental biology, quantitative methods, computational modeling, and data-driven analysis to understand how biological systems behave across scales.
What type of grant mechanism is used?
The opportunity uses the NIH P50 activity code, which generally supports specialized center grants that may include multiple integrated projects and shared resources organized under a unified scientific theme.
What is the award ceiling?
The listed award ceiling is $2,000,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What is the funding activity category?
The funding activity category is Health.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.859, Biomedical Research and Research Training.
Are training and outreach part of what the program supports?
Yes. In addition to research, the opportunity explicitly highlights research training and outreach as core components, consistent with a center model that coordinates multi-project efforts and broader community impact (for example, sharing knowledge, tools, or approaches).
Which organizations are eligible to apply?
While the eligibility section lists a broad range of organization types that can generally apply for federal assistance (including higher education institutions, nonprofits, state and local governments, tribal governments and organizations, and certain for-profit entities), the practical eligibility for this specific announcement is limited to organizations submitting renewal applications for existing NIGMS National Centers for Systems Biology awards.
Can a non-U.S. (foreign) institution apply directly?
No. The notice states that non-U.S. (foreign) institutions are not eligible to apply directly.
Are non-U.S. components of U.S. organizations eligible?
No. The notice states that non-U.S. components of U.S. organizations are not eligible.
Are any foreign elements allowed at all?
Yes. Foreign components (as defined by NIH policy) are allowable, meaning a U.S.-led application may include a justified foreign component when it is essential to the project.
What were the key dates for this opportunity?
The posting and creation date was August 12, 2014. The closing date (original and current) was October 23, 2015. The archive date was November 23, 2015.
Is this funding opportunity still active?
No. Based on the listed closing date and archive date, the opportunity is no longer active.
Where were applicants directed to find the full announcement?
Applicants and institutional officials were directed to the NIH Grants Guide link for the full announcement.
Where were technical access issues directed?
Technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact.
What kinds of activities were centers generally expected to maintain or strengthen in a renewal?
The description emphasizes continuing pioneering, interdisciplinary systems biology research, typically integrating experimental work with quantitative and computational approaches, while also maintaining a strong environment for research training and outreach to extend the center's impact.
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