Opportunity Information: Apply for RFA AG 13 018
Apply for RFA AG 13 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jan 16, 2013 and posted on Jan 16, 2013.
- Applicants must submit their applications by Mar 20, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Public and State controlled institutions of higher education City or township governments Independent school districts Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01) is a National Institutes of Health (NIH) funding opportunity (RFA-AG-13-018) focused on adding DNA collection to already-established longitudinal aging studies in Africa and other developing-country settings. The central aim is to support revision applications to existing projects, not brand-new cohort creation, so that investigators can collect DNA from older adult participants (defined here as age 50 and above) who are already being followed over time and who already contribute rich behavioral and social data. The FOA is built around the idea that these cohorts are uniquely valuable because they pair detailed longitudinal survey information with the potential to generate genetic data, enabling future research that can link biology with social, behavioral, and environmental exposures across aging.
The opportunity specifically targets longitudinal surveys that have strong data stewardship practices, meaning their data have been archived and shared in ways that allow qualified researchers to access and use them. The announcement highlights well-known platforms such as the World Health Organization Study on global AGEing and Adult Health (SAGE) and the International Network for the Demographic Evaluation of Populations and their Health in Developing Countries (INDEPTH), along with other National Institute on Aging (NIA)-supported longitudinal studies in Africa that have appropriate data sharing plans. In practical terms, NIH is trying to build a foundation of biospecimens linked to high-quality longitudinal phenotypes, while ensuring that those linked datasets can actually be used by the broader research community.
A major theme of the FOA is urgency and scientific validity. It emphasizes collecting DNA as early as possible within these ongoing cohorts so that the biospecimen sample remains as close as possible to the original sampling frame. The logic is straightforward: longitudinal studies often experience attrition over time, and that dropout is frequently selective (for example, related to health status, socioeconomic factors, mobility, or mortality risk). When attrition is selective, missing data are not random, and the subset of participants still available years later can differ in meaningful ways from the baseline population. If DNA collection is delayed, the genetic sample could become biased toward those who remained in the study, which would weaken the interpretability and generalizability of future genetic analyses. By funding timely DNA collection now, NIH is trying to preserve the scientific integrity of later genotyping and gene-environment research.
From an administrative standpoint, this is a discretionary grant opportunity using the R01 activity mechanism, categorized under Aging Research (CFDA 93.866). It does not require cost sharing or matching. The FOA was posted on January 16, 2013, with an original and current closing date of March 20, 2013, and an archive date of April 20, 2013. Because it is labeled a limited competition and geared toward revision applications, it is intended for teams already running qualifying longitudinal cohorts that can feasibly add DNA collection and align that effort with established data-sharing practices.
Eligibility is broad and includes a wide range of U.S. and non-U.S. entities. Eligible applicants span public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations (other than small businesses), governmental units (state, county, city/township, special districts), public housing authorities/Indian housing authorities, independent school districts, and tribal governments and organizations. The FOA explicitly allows non-domestic (non-U.S.) entities and foreign institutions to apply, and also permits foreign components of U.S. organizations as allowed under NIH policy. It also calls out eligibility for many mission-specific institution types and community-based organizations, including HBCUs, Hispanic-serving institutions, AANAPISIS institutions, TCCUs, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and U.S. territories or possessions.
Overall, the grant opportunity is best understood as an infrastructure-and-capacity enhancement to existing African aging cohorts: it seeks to add DNA collection in a timely, methodologically careful way so that future researchers can conduct genetic and genomic analyses that are properly anchored to the original cohort design and strengthened by robust longitudinal behavioral and social data.
FAQs: Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01) (RFA-AG-13-018)
What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity titled "Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01)." It is identified as RFA-AG-13-018 and supports adding DNA collection to already-established longitudinal aging studies in Africa and other developing-country settings.
Which NIH activity mechanism does this opportunity use?
The opportunity uses the R01 activity mechanism and is described as a discretionary grant opportunity.
What is the central goal of the FOA?
The central aim is to support revision applications to existing projects so investigators can collect DNA from older adult participants (age 50 and above) who are already being followed over time and who already contribute rich behavioral and social data.
Is this funding meant for creating a brand-new cohort study?
No. The FOA is built around revision applications to existing longitudinal cohort projects, not establishing brand-new cohorts.
Who are the target participants for DNA collection?
The FOA focuses on older adult participants defined here as age 50 and above who are already enrolled in existing longitudinal aging cohorts.
Where should the underlying cohort studies be based?
The opportunity targets longitudinal aging studies in Africa and other developing-country settings, with a strong emphasis on African cohorts.
What kinds of data are expected to already exist in the cohort?
The FOA emphasizes cohorts that already include rich longitudinal survey information, especially behavioral and social data collected over time.
What is meant by "adding DNA collection" in this context?
It refers to enhancing an ongoing longitudinal cohort by collecting DNA biospecimens from participants, with the intent of linking those biospecimens to existing longitudinal phenotype data (behavioral, social, and related measures).
Why does the FOA emphasize collecting DNA as early as possible?
The FOA highlights urgency because longitudinal cohorts often experience attrition over time, and that attrition can be selective (related to health, socioeconomic status, mobility, or mortality risk). Collecting DNA earlier helps keep the biospecimen sample closer to the original sampling frame and helps reduce the risk of bias in future genetic analyses.
What problem is NIH trying to avoid by funding DNA collection now?
The FOA is concerned that if DNA collection is delayed, the genetic sample may become biased toward participants who remained in the study for longer periods. That can weaken interpretability and generalizability of later genetic and gene-environment research.
What future research is this FOA trying to enable?
By linking DNA to detailed longitudinal survey data, the FOA aims to enable future genetic and genomic research that connects biology with social, behavioral, and environmental exposures across aging.
Does the FOA mention any example cohort platforms?
Yes. It highlights well-known platforms such as the World Health Organization Study on global AGEing and Adult Health (SAGE) and the International Network for the Demographic Evaluation of Populations and their Health in Developing Countries (INDEPTH), as well as other National Institute on Aging (NIA)-supported longitudinal studies in Africa that have appropriate data sharing plans.
What does the FOA mean by "strong data stewardship practices"?
In this FOA, strong data stewardship refers to cohorts whose data have been archived and shared in ways that allow qualified researchers to access and use them, supported by appropriate data-sharing practices.
Is data sharing important for this opportunity?
Yes. The FOA specifically targets surveys with demonstrated data archiving and sharing that allows qualified researchers to access and use the data, reinforcing the goal of broad scientific utility.
What is the funding category and CFDA number listed for the opportunity?
The FOA is categorized under Aging Research with CFDA 93.866.
Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching.
What does "limited competition" imply here?
Based on the FOA description, it is limited because it is geared toward revision applications from teams already running qualifying longitudinal cohorts that can feasibly add DNA collection and align with established data-sharing practices, rather than open-ended new cohort creation.
What types of organizations are eligible to apply?
Eligibility is broad and includes (among others) public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); small businesses; for-profit organizations (other than small businesses); and various governmental units.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly allows non-domestic (non-U.S.) entities and foreign institutions to apply, and also permits foreign components of U.S. organizations as allowed under NIH policy.
Do specific institution types and community-based organizations qualify?
Yes. The FOA calls out eligibility for many mission-specific and community-based entities, including HBCUs, Hispanic-serving institutions, AANAPISIS institutions, TCCUs, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and U.S. territories or possessions.
Which governmental entities are included in eligibility?
The FOA lists eligibility for governmental units such as state, county, city/township governments, special districts, as well as tribal governments and organizations.
Are public housing authorities included as eligible applicants?
Yes. Public housing authorities/Indian housing authorities are explicitly listed as eligible.
Are independent school districts eligible?
Yes. Independent school districts are included in the eligibility list.
What are the key dates for this FOA?
The FOA was posted on January 16, 2013. The original and current closing date is March 20, 2013. The archive date is April 20, 2013.
Is this opportunity still open based on the dates provided?
Based on the provided dates, the closing date was March 20, 2013 and the FOA was archived on April 20, 2013.
What makes these cohorts "uniquely valuable" according to the FOA?
The FOA emphasizes that established longitudinal aging cohorts are uniquely valuable because they combine detailed, repeated-measures survey data with the opportunity to add genetic data, supporting research that can link biology with social, behavioral, and environmental exposures over time.
What is NIH trying to build through this FOA?
NIH is trying to build a foundation of DNA biospecimens linked to high-quality longitudinal phenotypes, paired with data stewardship and sharing practices that allow broader use by qualified researchers.
What kind of application does this FOA primarily support?
It supports revision applications to existing projects (teams already operating qualifying longitudinal cohorts) to add DNA collection in a timely and methodologically careful way.
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