Opportunity Information: Apply for PAR 14 066
Apply for PAR 14 066
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Specific pathogen free macaque colonies (U42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351 Research Infrastructure Programs.
- This funding opportunity was created on Jan 9, 2014 and posted on Jan 9, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The funding opportunity titled "Limited Competition Specific pathogen free macaque colonies (U42)" (Funding Opportunity Number PAR-14-066) is a National Institutes of Health (NIH) cooperative agreement program designed to support and sustain specialized research infrastructure in the form of specific pathogen free (SPF) macaque colonies. The core purpose is to maintain and provide high-quality nonhuman primate resources that are free of particular infectious agents, which is essential for many areas of biomedical research where hidden or endemic infections can compromise animal health, distort experimental results, or introduce safety risks. By focusing on SPF macaque colonies, NIH is aiming to strengthen the reliability, reproducibility, and overall value of research that depends on macaque models, especially studies where immune function, infectious disease outcomes, vaccine responses, transplantation, or other biologically sensitive endpoints could be affected by undetected pathogens.
This opportunity falls under the "Discretionary" opportunity category and uses the Cooperative Agreement funding instrument (U42). A cooperative agreement typically means that NIH expects to have substantial involvement in the project beyond standard grant stewardship. In practice, this often aligns with projects that are resource-oriented, operationally complex, and intended to serve a broader scientific community rather than only the awardee's internal research program. The funding activity category is "Health," and the program is associated with CFDA number 93.351, which is tied to Research Infrastructure Programs. The emphasis on infrastructure is important: this is not simply a research project grant to test a hypothesis, but support for building, maintaining, and improving a resource that enables many downstream studies.
The announcement indicates that application due dates are not presented as a single fixed deadline in the summary data and instead notes "Multiple dates, see announcement," meaning applicants were expected to consult the full NIH posting for the specific submission schedule and cycle dates. The opportunity was posted and created on January 9, 2014. The original closing date and the listed current closing date are both January 7, 2018, and the archive date is February 7, 2018, indicating the solicitation is no longer active and is preserved for historical reference. In other words, this particular announcement is closed, but it can still be useful for understanding NIH priorities, required capabilities, and the structure NIH uses when it periodically recompetes or renews infrastructure resources of this kind.
Eligibility is broad across several types of nonprofit and academic institutions, with the key qualifier that the competition is "limited," which usually signals that only certain organizations that meet specific criteria, have a particular track record, or are otherwise identified in the full text may apply. The eligible applicant categories listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status (other than institutions of higher education), nonprofits without 501(c)(3) status (again, other than institutions of higher education), and "Others (see text field entitled Additional Information on Eligibility for clarification)." The eligibility information also explicitly includes several institution types that NIH frequently highlights to encourage broad participation: Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and similar organizations. No cost sharing or matching is required, which lowers the financial barrier to participation and is consistent with many NIH infrastructure awards where the agency is investing directly in national research capacity.
From an operational standpoint, a program supporting SPF macaque colonies generally implies expectations around colony management, veterinary oversight, biosecurity, routine pathogen surveillance and diagnostic testing, standardized documentation, and careful husbandry practices that maintain the SPF status over time. It also typically involves formal systems for animal identification, health records, breeding management, quarantine procedures, and possibly the distribution of animals or biological materials to qualified investigators. Because SPF status depends on controlling both known and emerging infectious risks, awardees commonly need strong quality management systems, trained personnel, appropriate facilities, and well-defined standard operating procedures. Cooperative agreement mechanisms also commonly come with coordination requirements, such as participation in NIH-led meetings, reporting of standardized metrics (for example, colony size, breeding productivity, testing outcomes, and animal allocation), and alignment with NIH programmatic guidance on how the resource serves the research community.
For applicants and interested parties seeking the official details, NIH provided an additional information link to the full announcement on the NIH Grants Guide website (http://grants.nih.gov/grants/guide/pa-files/PAR-14-066.html). For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV, with a note that the same contact can assist with problems linking to the funding announcement.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Limited Competition Specific pathogen free macaque colonies (U42)" and the Funding Opportunity Number is PAR-14-066.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of funding mechanism is used?
The funding instrument is a Cooperative Agreement (U42). This structure is commonly used for projects that are resource-oriented, operationally complex, and intended to serve a broader scientific community.
What does a "cooperative agreement" (U42) imply for awardees?
A cooperative agreement typically indicates that NIH expects substantial involvement beyond standard grant oversight. Based on the description provided, this may include coordination requirements such as participation in NIH-led meetings, reporting standardized metrics, and aligning operations with NIH programmatic guidance for how the resource serves the research community.
What is the main purpose of this funding opportunity?
The core purpose is to support and sustain specialized research infrastructure in the form of specific pathogen free (SPF) macaque colonies. The goal is to maintain and provide high-quality nonhuman primate resources that are free of particular infectious agents.
Why are SPF macaque colonies important for biomedical research?
Hidden or endemic infections can compromise animal health, distort experimental results, or introduce safety risks. NIH is emphasizing SPF colonies to strengthen the reliability, reproducibility, and overall value of macaque-based research, especially where outcomes could be affected by undetected pathogens.
What research areas are most likely to benefit from SPF macaque resources?
The description highlights studies where immune function, infectious disease outcomes, vaccine responses, transplantation, or other biologically sensitive endpoints could be influenced by undetected pathogens.
Is this opportunity meant to fund hypothesis-driven research projects?
No. The emphasis is on research infrastructure. The opportunity is framed as support for building, maintaining, and improving a resource that enables many downstream studies, rather than a single research project designed to test a specific hypothesis.
What is the opportunity category and activity category?
The opportunity category is Discretionary, and the funding activity category is Health.
What CFDA number is associated with this program?
The program is associated with CFDA number 93.351, tied to Research Infrastructure Programs.
When was this funding opportunity posted?
The opportunity was posted and created on January 9, 2014.
Is this funding opportunity still open?
No. The original closing date and the listed current closing date are both January 7, 2018, and the archive date is February 7, 2018. This indicates the solicitation is no longer active and is preserved for historical reference.
How were application due dates handled for this opportunity?
The summary indicates "Multiple dates, see announcement," meaning applicants were expected to consult the full NIH posting for the specific submission schedule and cycle dates rather than relying on a single fixed deadline in the summary.
What does "limited competition" mean in this context?
The competition is described as "limited," which usually means only certain organizations that meet specific criteria, have a particular track record, or are otherwise identified in the full text may apply. The precise limitations would be detailed in the full announcement.
What types of organizations were listed as eligible applicants?
Eligible categories listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status (other than institutions of higher education), nonprofits without 501(c)(3) status (other than institutions of higher education), and "Others" as clarified in the announcement's Additional Information on Eligibility.
Does the eligibility language include minority-serving institutions?
Yes. The eligibility information explicitly includes institution types NIH often highlights, such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), among similar organizations.
Is cost sharing or matching required?
No. The opportunity states that no cost sharing or matching is required.
What kinds of operational capabilities are typically implied for SPF macaque colony support?
Based on the description, expectations generally imply colony management, veterinary oversight, biosecurity, routine pathogen surveillance and diagnostic testing, standardized documentation, and husbandry practices designed to maintain SPF status over time.
What kinds of systems and procedures are commonly associated with maintaining SPF status?
The description references the need for formal systems for animal identification, health records, breeding management, quarantine procedures, and possibly distribution of animals or biological materials to qualified investigators. Maintaining SPF status also commonly requires quality management systems, trained personnel, appropriate facilities, and well-defined standard operating procedures.
What reporting or coordination requirements might be expected under a U42 cooperative agreement?
As described, cooperative agreements commonly involve coordination such as participating in NIH-led meetings, reporting standardized metrics (for example, colony size, breeding productivity, testing outcomes, and animal allocation), and aligning operations with NIH programmatic guidance on serving the research community.
Where can someone find the official full announcement?
The full announcement is available on the NIH Grants Guide website at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-066.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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