Opportunity Information: Apply for PAR 14 329
Apply for PAR 14 329
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Strategic Timing of Antiretroviral Treatment (START) (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Aug 29, 2014 and posted on Aug 29, 2014.
- Applicants must submit their applications by Nov 19, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Only the current START awardee is eligible to apply to this limited competition FOA.
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Opportunity Summary:
The grant opportunity titled "Limited Competition Strategic Timing of Antiretroviral Treatment (START) (UM1)" (Funding Opportunity Number PAR-14-329) is a National Institutes of Health (NIH) funding announcement designed specifically to continue and finish work on an existing major HIV clinical trial known as START. The core aim of the START trial is to answer a high-impact clinical question in HIV care: whether starting antiretroviral treatment (ART) immediately after a person is identified as HIV-positive leads to better long-term health outcomes than delaying treatment. In practical terms, the study is structured as a randomized clinical trial that compares immediate ART initiation against deferred initiation, with outcomes focused on whether early therapy reduces or postpones serious HIV-related complications (AIDS events), other major illnesses not traditionally classified as AIDS (non-AIDS events), and death.
This opportunity is categorized as a discretionary grant and uses the Cooperative Agreement mechanism (UM1). A cooperative agreement generally indicates substantial involvement by the NIH in the funded activity, which is common for large, complex clinical trials where coordination, oversight, and adherence to standardized protocols are critical. The activity category is Health, and the listed CFDA numbers reflect the biomedical areas it touches, including mental health research grants (93.242) and infectious disease-related research areas within allergy/immunology and microbiology/infectious diseases (93.855 and 93.856). The announcement specifies that there is no cost-sharing or matching requirement, meaning the applicant is not required to contribute non-federal funds as a condition of the award.
A defining feature of this FOA is that it is a limited competition. Eligibility is tightly restricted: only the current START awardee is allowed to apply. That restriction is explicitly stated in the eligibility section and signals that NIH’s intent is not to open a new competition for new institutions, but to ensure continuity of operations, staffing, data collection, follow-up, and analysis needed to bring the existing START trial to completion. This kind of limited competition is often used when a long-running, multi-site trial is already underway and changing leadership or infrastructure midstream could compromise timelines, data integrity, participant follow-up, or regulatory compliance.
In terms of timeline, the opportunity was posted and created on August 29, 2014, with an original and current closing date of November 19, 2014. The archive date is December 20, 2014, meaning it is no longer active and is maintained primarily for recordkeeping and reference. The announcement provides an NIH Grants Guide link for full details and includes contact information for the NIH Office of Extramural Research (OER) Webmaster for technical issues related to accessing or linking to the announcement.
Overall, PAR-14-329 is best understood as a continuation funding pathway aimed at completing a pivotal randomized trial evaluating the health benefits of immediate ART initiation in people living with HIV, with endpoints spanning AIDS-related outcomes, broader serious health events, and mortality. The structure, funding mechanism, and limited eligibility reflect the need for stability and NIH partnership while finishing a complex clinical study intended to directly inform HIV treatment timing and clinical guidelines.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Limited Competition Strategic Timing of Antiretroviral Treatment (START) (UM1)" and the Funding Opportunity Number (FOA) is PAR-14-329.
What is the purpose of this funding opportunity?
This NIH funding announcement is designed to continue and finish work on the existing major HIV clinical trial known as START. It is intended to support continuity of operations, follow-up, data collection, and analysis required to bring the trial to completion.
What is the START trial studying?
The START trial addresses a major clinical question in HIV care: whether starting antiretroviral treatment (ART) immediately after a person is identified as HIV-positive leads to better long-term health outcomes than delaying treatment.
How is the START trial structured?
The study is structured as a randomized clinical trial comparing immediate initiation of ART versus deferred initiation. The trial design is intended to rigorously evaluate differences in outcomes between these two strategies.
What outcomes does the START trial focus on?
The outcomes focus on whether early therapy reduces or postpones serious HIV-related complications (AIDS events), other major illnesses not traditionally classified as AIDS (non-AIDS events), and death.
What type of grant is this?
This opportunity is categorized as a discretionary grant.
What funding mechanism does this FOA use?
The FOA uses the Cooperative Agreement mechanism (UM1).
What does it mean that this is a cooperative agreement (UM1)?
A cooperative agreement generally indicates substantial involvement by NIH in the funded activity. This is common for large, complex clinical trials where coordination, oversight, and adherence to standardized protocols are critical.
Is this a new competition open to multiple organizations?
No. A defining feature of this FOA is that it is a limited competition. NIH is not opening a new competition for new institutions under this announcement.
Who is eligible to apply?
Eligibility is tightly restricted: only the current START awardee is allowed to apply. This restriction is explicitly stated in the eligibility section of the announcement.
Why is the competition limited to the current START awardee?
The limited competition approach reflects NIH intent to ensure continuity of operations, staffing, data collection, follow-up, and analysis needed to complete the existing trial. Changing leadership or infrastructure midstream could compromise timelines, data integrity, participant follow-up, or regulatory compliance.
What is the activity category for this funding opportunity?
The activity category listed for this opportunity is Health.
Which CFDA numbers are associated with this opportunity?
The announcement lists CFDA numbers 93.242, 93.855, and 93.856, reflecting the biomedical areas it touches, including mental health research grants and infectious disease-related research areas within allergy/immunology and microbiology/infectious diseases.
Is cost sharing or matching required?
No. The announcement specifies there is no cost-sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
When was this opportunity posted?
The opportunity was posted and created on August 29, 2014.
What was the application closing date?
The original and current closing date listed is November 19, 2014.
Is this funding opportunity still active?
No. The archive date is December 20, 2014, which indicates the opportunity is no longer active and is maintained primarily for recordkeeping and reference.
Where can someone find the full official details?
The announcement provides a link to the NIH Grants Guide for full details.
Who should be contacted for technical issues with accessing or linking to the announcement?
The FOA includes contact information for the NIH Office of Extramural Research (OER) Webmaster for technical issues related to accessing or linking to the announcement.
What is the overall intent of PAR-14-329?
PAR-14-329 is best understood as a continuation funding pathway aimed at completing a pivotal randomized trial evaluating the health benefits of immediate ART initiation in people living with HIV, with endpoints spanning AIDS-related outcomes, broader serious health events, and mortality.
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