Opportunity Information: Apply for RFA AG 10 005
Apply for RFA AG 10 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition The National Institute on Aging Multicenter Study on Exceptional Survival in Families The Long Life Family Study (LLFS) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 29, 2009 and posted on Jul 29, 2009.
- Applicants must submit their applications by Sep 30, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,400,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Private institutions of higher education City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Non domestic (non U.S.) Entities (Foreign Organizations) The only eligible organizations are the current recipients of the LLFS awards funded through RFA AG 03 004.
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Opportunity Summary:
This funding opportunity, RFA-AG-10-005, is a limited competition grant announcement from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH). Its main goal is straightforward: to continue the Long Life Family Study (LLFS), a large multicenter research effort focused on understanding exceptional longevity and healthy survival in families. The LLFS was originally set up to measure how exceptional survival to very old age tends to run in families, what patterns of inheritance or familial clustering can be observed, and how those survival patterns relate to a wide range of observable traits (phenotypes). Alongside those clinical and functional measures, the study also aims to clarify possible genetic contributors to unusually long and healthy lives, building a stronger evidence base for why some families show repeated instances of exceptional survival.
The FOA uses the NIH cooperative agreement mechanism (U01), which signals a more collaborative arrangement than a standard research project grant. Under a U01, NIH program staff typically have substantial involvement in coordinating or steering aspects of the work, reflecting the complexity of multicenter studies that require harmonized procedures, shared data standards, and coordinated oversight across sites. In this case, the continued operation of the LLFS depends on maintaining consistent protocols and centralized coordination so that ongoing or future analyses remain comparable to prior study phases.
The opportunity anticipates funding up to five awards, matching the structure of the existing LLFS program: four study centers plus one data management and coordinating center. This mirrors the original LLFS award structure established under the earlier solicitation (RFA AG 03 004), which funded five awards total. The presence of a dedicated data management and coordinating center highlights that the program is not just about collecting new information, but also about curating, standardizing, and distributing data in ways that support high-quality multicenter research, long-term follow-up, and rigorous analysis across sites.
Funding levels are laid out across fiscal years, with NIA intending to commit an estimated total of $8.4 million in total costs starting in FY2010. The announcement also provides projected out-year totals of up to $6.0 million in FY2011 and up to $5.2 million in FY2012, again in total costs. These amounts are intended to support the continuation of the study infrastructure and scientific work across the five awards, reflecting both the scale of the cohort and the operational demands of long-term, family-based longevity research.
Although the general NIH eligibility list includes a wide range of organization types (such as nonprofit and for-profit organizations, higher education institutions, and state and local governments, plus certain foreign entities and federal agencies), the competition is explicitly restricted. The only organizations eligible to apply are the current recipients of the LLFS awards funded through RFA AG 03 004. In other words, this is not an open call for new institutions to join the program; it is a continuation mechanism designed to keep the existing LLFS network operating and productive, preserving continuity in methods, cohorts, and data systems.
Administratively, the grant is categorized as discretionary funding, with no cost sharing or matching requirement. The opportunity was posted on July 29, 2009, with an original and current closing date of September 30, 2009, and an archive date of October 31, 2009. The CFDA number associated with this announcement is 93.866 (Aging Research), which places it within NIH’s aging and gerontology research portfolio.
For those seeking more technical or administrative detail, the full announcement was hosted through the NIH grants guide at the link provided in the notice. The contact information included is primarily technical support-oriented (NIH Office of Extramural Research webmaster contacts) for access or linking issues, which is typical for listings where scientific/program contacts are detailed in the full FOA text.
Frequently Asked Questions (FAQs) - RFA-AG-10-005 (Long Life Family Study Continuation)
What is the funding opportunity RFA-AG-10-005?
RFA-AG-10-005 is a limited competition grant announcement from the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH). The purpose of this opportunity is to continue the Long Life Family Study (LLFS), a large multicenter research program focused on exceptional longevity and healthy survival in families.
What is the main goal of this grant?
The main goal is to continue operating the Long Life Family Study (LLFS) so the existing multicenter network can maintain consistent protocols and centralized coordination and support ongoing and future analyses that remain comparable to earlier phases of the study.
What is the Long Life Family Study (LLFS)?
The LLFS is a large, multicenter research effort designed to study exceptional survival to very old age within families. It examines how exceptional longevity clusters in families, what patterns of inheritance or familial clustering can be observed, and how those survival patterns relate to a broad range of measured traits (phenotypes). It also seeks to clarify potential genetic contributors to unusually long and healthy lives.
Why does the FOA emphasize consistent protocols and centralized coordination?
Because LLFS is a multicenter study, continued success depends on harmonized procedures across sites, shared data standards, and coordinated oversight. Keeping protocols consistent helps ensure that data collected over time and across locations remain comparable to earlier LLFS phases, supporting rigorous long-term follow-up and analysis.
What NIH funding mechanism is used for this opportunity?
This opportunity uses the NIH cooperative agreement mechanism (U01). A U01 typically involves substantial NIH program staff involvement in coordinating or steering aspects of the work, which is common for complex multicenter programs that require coordinated operations and shared infrastructure.
How is a U01 cooperative agreement different from a standard research grant?
Based on the information provided, the key difference highlighted is that a U01 is more collaborative than a standard research project grant, with NIH program staff generally having substantial involvement in coordinating or steering certain aspects of the work to support effective multicenter coordination.
How many awards does NIA expect to make under RFA-AG-10-005?
The announcement anticipates funding up to five awards.
What types of awards make up the five-award structure?
The expected structure mirrors the existing LLFS program: four study centers plus one data management and coordinating center. This matches the original LLFS award structure established under the earlier solicitation (RFA AG 03 004).
What is the role of the data management and coordinating center?
The presence of a dedicated data management and coordinating center indicates the program includes not only data collection, but also data curation, standardization, and distribution. This supports high-quality multicenter research, long-term follow-up, and rigorous analyses across sites.
How much funding is NIA planning to commit?
NIA intends to commit an estimated total of $8.4 million in total costs starting in FY2010. The announcement also provides projected out-year totals of up to $6.0 million in FY2011 and up to $5.2 million in FY2012 (also in total costs).
Do the funding amounts apply per award or across the whole program?
The amounts described are presented as totals intended to support continuation of the study infrastructure and scientific work across the five awards.
Is this a discretionary or mandatory funding opportunity?
The grant is categorized as discretionary funding.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply for RFA-AG-10-005?
Eligibility is explicitly restricted. The only organizations eligible to apply are the current recipients of the LLFS awards funded through RFA AG 03 004. This is not an open call for new institutions to join the LLFS program.
Does the NIH general eligibility list apply here?
The listing notes that NIH eligibility categories can include many organization types (including nonprofit and for-profit organizations, higher education institutions, state and local governments, certain foreign entities, and federal agencies). However, this particular competition is limited to the current LLFS award recipients under RFA AG 03 004.
Is this opportunity open to new study centers or new coordinating centers?
No. Based on the restriction described, the opportunity is intended as a continuation mechanism for the existing LLFS network rather than an open solicitation for new participating institutions.
What are the key dates for this funding opportunity?
The opportunity was posted on July 29, 2009. The original and current closing date is September 30, 2009. The archive date is October 31, 2009.
What is the CFDA number for this opportunity?
The CFDA number associated with this announcement is 93.866, which corresponds to Aging Research.
Where does this opportunity fit within NIH's research portfolio?
It is within NIA's aging and gerontology research portfolio, as indicated by the institute sponsoring it (NIA) and the CFDA listing for Aging Research (93.866).
Where can applicants find the full announcement?
The full announcement was hosted through the NIH grants guide at the link referenced in the notice. The listing indicates that more technical or administrative detail is available in the full FOA text.
What contact information is provided in the notice?
The contact information included is primarily technical support-oriented, specifically NIH Office of Extramural Research webmaster contacts for access or linking issues. Scientific or program contacts are typically provided within the full FOA text.
Why is this described as a continuation mechanism?
The notice explains that only current LLFS awardees funded under RFA AG 03 004 may apply, and it emphasizes preserving continuity in methods, cohorts, and data systems. Those features indicate the intent is to keep the existing LLFS infrastructure operating and productive rather than launching a new, open competition.
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