Limited Competition Womens Interagency HIV Study (WIHS V) (U01) | Apply Online

Opportunity Summary:

The Limited Competition Womens Interagency HIV Study (WIHS V) (U01) grant opportunity (Funding Opportunity Number RFA-AI-12-002) is a National Institutes of Health (NIH) cooperative agreement aimed at continuing and expanding a major U.S. epidemiologic cohort focused on women affected by HIV. The central goal of WIHS V is to document and better understand the long-term course of HIV infection in women over time, including both the natural history of infection and outcomes under modern treatment. Just as importantly, the initiative is designed to refresh and strengthen the cohort by recruiting and retaining new participants so the study reflects shifting realities in the U.S. HIV epidemic among women, including changes in demographics, geography, and clinical patterns as treatment and prevention evolve.

This is a limited competition, meaning it is not broadly open to all institutions. NIH is specifically inviting applications from the existing WIHS Clinical Research Sites (CRS), from the current WIHS Data Management and Analysis Center (WDMAC), and from one additional, new Clinical Research Site located in and able to enroll targeted populations of women from the Southern United States. The eligible Southern-region states are restricted to Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, and Texas. The emphasis on the South reflects a strategic interest in ensuring that the cohort captures women from a region that has carried a substantial and in many areas growing burden of HIV, and where the epidemic can look different in terms of access to care, socioeconomic factors, and affected communities.

Because the award mechanism is a U01 cooperative agreement, recipients should expect substantial programmatic involvement from NIH compared with a typical research project grant. In practical terms, WIHS V is structured as a coordinated network in which the funded sites and the data management center operate together as parts of a single, integrated cohort study. The announcement makes clear that all awards made under this FOA collectively form the WIHS V epidemiologic cohort, underscoring that the intent is not to fund disconnected projects but to maintain a unified, standardized research platform capable of producing comparable data across locations and over time.

The opportunity is categorized as discretionary funding and sits within broad activity areas that include education, health, and income security/social services. The listed CFDA program areas span multiple NIH-related research domains, including mental health (93.242), drug abuse and addiction research (93.279), cancer biology (93.396), allergy and infectious diseases (93.855), microbiology and infectious diseases (93.856), and child health and human development extramural research (93.865). This range signals that the cohort is expected to support multidisciplinary research questions relevant to women living with or at risk for HIV, including comorbidities and intersecting conditions that commonly influence outcomes over the long term.

The estimated total funding level for the FOA is approximately $23.9 million, and there is no cost-sharing or matching requirement. The announcement was posted on November 29, 2011, with an original and current closing date of February 22, 2012, and an archive date of March 24, 2012. Eligibility is narrowly defined: specific existing awardee institutions tied to prior WIHS U01 awards are listed as eligible applicants, including Montefiore Medical Center (Bronx, NY), SUNY Downstate Medical Center (Brooklyn, NY), Hektoen Institute for Medical Research (Chicago, IL), University of Southern California (Los Angeles, CA), University of California San Francisco (San Francisco, CA), Georgetown University (Washington, DC), and Johns Hopkins University (Baltimore, MD) as the Data Management and Analysis Center. The FOA also explicitly excludes non-U.S. entities, non-U.S. components of U.S. organizations, and foreign components as defined by NIH policy, reinforcing that this cohort effort is intended to be conducted entirely within the United States.

Overall, WIHS V is best understood as continued federal support for a long-running, highly coordinated national cohort designed to generate rigorous longitudinal evidence about HIV in women, while updating and expanding recruitment to reflect where and among whom the epidemic is occurring now. The structure of the FOA highlights both continuity (supporting existing sites and the established data center) and targeted expansion (adding a Southern clinical research site) to ensure the cohort remains scientifically useful, geographically relevant, and representative of changing U.S. demographics.

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