Opportunity Information: Apply for RFA MH 15 110
Apply for RFA MH 15 110
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Longitudinal Assessment of Post traumatic Syndromes (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on May 6, 2014 and posted on May 6, 2014.
- Applicants must submit their applications by Nov 6, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $5,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) City or township governments State governments Native American tribal governments (Federally recognized) Small businesses Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Longitudinal Assessment of Post-traumatic Syndromes (U01) funding opportunity (RFA-MH-15-110) was a National Institutes of Health (NIH) discretionary grant announcement in the mental health research area (CFDA 93.242) designed to support a single, large cooperative agreement project. The core idea was to build a multi-site, longitudinal research platform that follows adult trauma patients starting at the earliest feasible point after injury, specifically in emergency rooms and other acute trauma care settings. Rather than focusing only on who does or does not develop a specific diagnosis, the FOA emphasizes mapping different post-trauma trajectories over time using a broad set of measurable dimensions that cut across behavior, brain function, physiology, and related domains.
Scientifically, the announcement laid out four connected goals. First, it sought detailed characterization of post-traumatic trajectories using observable behavior and neurobiological and other measurable indicators that may function as risk markers. Examples named in the FOA include neural network functional connectivity, cognitive functioning, emotion regulation, and biomarkers related to immune response. The intention is to capture early signals that distinguish people who recover naturally from those who go on to experience persistent or worsening symptoms, and to do so with measures that are objective or quantifiable where possible.
Second, the FOA called for research that goes beyond description and tests processes or mechanisms that explain how post-trauma mental illness develops and is maintained. This is about identifying how different biological, cognitive, emotional, and contextual factors interact over time following a traumatic event. In practical terms, a project under this FOA would be expected to collect longitudinal data in a way that supports mechanistic inference, such as repeated measures that can show temporal ordering (what changes first, what follows) and relationships among symptoms, functioning, and biological signals.
Third, the announcement aimed to produce algorithms that can be used in the acute post-trauma period to predict which trajectory an individual is likely to follow. The emphasis on the acute window is important: the algorithms are meant to be actionable early, when patients are still in, or close to, emergency or acute care settings. This points toward the development of prediction tools that could eventually help clinicians triage risk, identify who might benefit from monitoring or early intervention, and avoid unnecessary intervention for those likely to recover without additional services.
Fourth, the FOA emphasized developing or refining measures of promising targets for future prevention and early treatment studies. In other words, the platform is not only intended to predict outcomes but also to sharpen the field’s ability to measure the factors that interventions might aim to change. This could include improved assessment tools, more sensitive biological or behavioral markers, or validated intermediate targets that can serve as endpoints in later trials focused on prevention or early treatment.
From a funding and administrative standpoint, this was a cooperative agreement (U01), which typically means substantial scientific or programmatic involvement from the NIH compared with a standard research project grant. The FOA anticipated making 1 award, with an estimated total funding level of $5,000,000 and an award ceiling of $5,000,000. There was no cost-sharing or matching requirement listed. The opportunity was posted May 6, 2014, with an original and current closing date of November 6, 2014, and an archive date of December 7, 2014.
Eligibility was broad and included many types of U.S. organizations and governments, such as state, county, city/township, special district, and independent school district governments; public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); small businesses and other for-profit organizations (with the small-business category explicitly listed); public housing authorities/Indian housing authorities; and Native American tribal governments (both federally recognized and other tribal entities) and tribal organizations. The eligibility text also explicitly included a range of mission- and population-focused institution types (for example HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations).
Overall, the opportunity was structured to create a coordinated, multi-site longitudinal infrastructure capable of enrolling adult trauma patients at the point of acute care, tracking them over time, and integrating behavioral, cognitive, neurobiological, and biomarker data. The expected deliverables were not just publications but also practical prediction algorithms and improved measures that could directly set up the next generation of prevention and early-intervention studies for post-trauma mental health outcomes.
Frequently Asked Questions (FAQs)
What is the Longitudinal Assessment of Post-traumatic Syndromes (U01) opportunity?
It is a National Institutes of Health (NIH) discretionary funding opportunity announcement (FOA) in the mental health research area focused on post-trauma outcomes. The specific announcement is titled "Longitudinal Assessment of Post-traumatic Syndromes (U01)" and is identified as RFA-MH-15-110.
What kind of award mechanism is used?
The FOA uses a cooperative agreement mechanism (U01). This typically involves substantial scientific or programmatic involvement from NIH compared with a standard research project grant.
How many awards were anticipated?
The FOA anticipated making 1 award to support a single, large cooperative agreement project.
What was the estimated total funding amount and maximum award size?
The estimated total funding level was $5,000,000, and the award ceiling was also $5,000,000.
Is cost sharing or matching required?
No cost-sharing or matching requirement was listed in the provided information.
What is the main purpose of the project supported by this FOA?
The core purpose is to build a coordinated, multi-site, longitudinal research platform that follows adult trauma patients starting at the earliest feasible point after injury, especially in emergency rooms and other acute trauma care settings.
What population is the platform intended to study?
The platform is designed to enroll and follow adult trauma patients beginning in the acute post-injury period.
Where does patient enrollment begin?
Enrollment is intended to begin as early as feasible after injury, specifically in emergency rooms and other acute trauma care settings.
Is this FOA focused only on a single diagnosis (for example, PTSD)?
No. The FOA emphasizes mapping different post-trauma trajectories over time and does not focus only on who does or does not develop a specific diagnosis.
What does the FOA mean by "post-trauma trajectories"?
It refers to different patterns of recovery or symptom development over time after a traumatic injury, including natural recovery and trajectories involving persistent or worsening symptoms.
What kinds of measurements and domains are emphasized?
The FOA emphasizes a broad set of measurable dimensions that cut across behavior, brain function, physiology, and related domains, with a preference for objective or quantifiable measures where possible.
What are the four connected scientific goals described in the announcement?
The FOA described four connected goals: (1) detailed characterization of post-traumatic trajectories using behavioral and neurobiological (and other measurable) indicators that may function as risk markers; (2) testing processes or mechanisms that explain how post-trauma mental illness develops and is maintained; (3) producing algorithms to predict which trajectory an individual is likely to follow during the acute post-trauma period; and (4) developing or refining measures of promising targets for future prevention and early treatment studies.
What are examples of risk markers or indicators mentioned?
Examples named include neural network functional connectivity, cognitive functioning, emotion regulation, and biomarkers related to immune response.
What is meant by "mechanisms" in this FOA?
The FOA calls for research that goes beyond description to test processes that explain how post-trauma mental illness develops and is maintained, including how biological, cognitive, emotional, and contextual factors interact over time following a traumatic event.
Why is longitudinal data collection important for this FOA?
Longitudinal collection with repeated measures supports mechanistic inference by helping establish temporal ordering (what changes first and what follows) and relationships among symptoms, functioning, and biological signals.
What kind of predictive products is the FOA aiming to produce?
The FOA aims to produce algorithms that can be used in the acute post-trauma period to predict which trajectory an individual is likely to follow.
Why does the FOA emphasize the acute post-trauma window?
The emphasis is on developing prediction tools that could be actionable early, when patients are still in, or close to, emergency or acute care settings, potentially enabling early risk triage and monitoring decisions.
How are the predictive algorithms intended to be used (conceptually)?
They are intended to support early identification of individuals likely to need monitoring or early intervention and to help avoid unnecessary intervention for individuals likely to recover without additional services.
Does the FOA fund prevention or early treatment trials directly?
The provided information describes the platform as setting up the next generation of prevention and early-intervention studies by refining measures and targets, rather than stating that it directly funds prevention or early treatment trials.
What does "developing or refining measures of promising targets" mean in this context?
It refers to improving assessment tools and markers (biological or behavioral) and validating intermediate targets that future prevention and early treatment studies could aim to change and could use as endpoints.
What are the expected deliverables?
Expected deliverables include a coordinated multi-site longitudinal infrastructure, practical prediction algorithms usable in the acute post-trauma period, and improved measures that can support future prevention and early-intervention research (in addition to publications).
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.242.
When was the opportunity posted, and what were the closing and archive dates?
It was posted May 6, 2014. The original and current closing date was November 6, 2014, and the archive date was December 7, 2014.
Who was eligible to apply based on the information provided?
Eligibility was broad and included many types of U.S. organizations and governments as well as non-U.S. entities (foreign organizations), as described in the FOA.
Are state and local governments eligible?
Yes. The eligibility list includes state governments; county governments; city or township governments; special district governments; and independent school district governments.
Are colleges and universities eligible?
Yes. Both public and private institutions of higher education are included as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofits are included, including 501(c)(3) and other nonprofit structures.
Are for-profit organizations eligible?
Yes. Small businesses and other for-profit organizations are included, with small businesses explicitly listed.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility text includes Native American tribal governments (federally recognized and other tribal entities) and tribal organizations.
Are U.S. territories and possessions eligible?
Yes. Regional organizations and U.S. territories or possessions are included in the eligibility description.
Are foreign (non-U.S.) organizations eligible?
Yes. Non-U.S. entities (foreign organizations) are explicitly included in the eligibility text.
Does the FOA explicitly include mission- or population-focused institution types?
Yes. Examples explicitly included are HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included in the eligibility description.
Are eligible federal agencies included?
Yes. Eligible federal agencies are listed among eligible applicant types.
Does the FOA require a multi-site approach?
The FOA is described as aiming to build a multi-site, longitudinal research platform, indicating a coordinated, multi-site structure is central to the project concept.
What distinguishes this FOA from studies that only categorize people into diagnostic groups?
The FOA emphasizes dimensional, trajectory-focused mapping over time using behavioral, cognitive, neurobiological, and biomarker data, rather than only classifying whether someone does or does not develop a single diagnosis.
What types of settings are highlighted for data collection?
Emergency rooms and other acute trauma care settings are highlighted as the starting point for enrolling participants and beginning follow-up.
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