Opportunity Information: Apply for RFA MH 16 500
Apply for RFA MH 16 500
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Longitudinal Assessment of Post traumatic Syndromes (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Jun 12, 2015 and posted on Jun 12, 2015.
- Applicants must submit their applications by Nov 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $13,300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) State governments Private institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Public and State controlled institutions of higher education City or township governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Longitudinal Assessment of Post-traumatic Syndromes (U01) funding opportunity (RFA-MH-16-500) is a National Institutes of Health (NIH) cooperative agreement designed to support a single, large-scale, multi-site research platform that follows adult trauma patients over time after they are first seen in emergency rooms or other acute trauma care settings. The core purpose is to build a longitudinal picture of how post-traumatic outcomes unfold, using a combination of real-world behavioral observations and biologically informed measures. By focusing on patients at the point of acute care, the project is aimed at capturing early indicators that may distinguish people who recover naturally from those who go on to develop persistent or worsening post-traumatic problems.
The scientific goals are twofold. First, the award is intended to characterize different post-traumatic trajectories in a dimensional way, meaning it looks beyond simple yes/no diagnoses and instead examines patterns of symptoms, functioning, and biological changes over time. The FOA highlights a range of potential markers of risk and recovery, including observable behavior, neurobiological changes, and other measurable indicators that could serve as early warning signs. Examples listed include neural network functional connectivity, cognitive functioning, emotion regulation capacity, and biomarkers related to immune response. In practice, this encourages research teams to integrate multiple data streams (clinical, behavioral, cognitive, neuroimaging or neurophysiology where feasible, and biological sampling) to map how post-traumatic syndromes develop and vary across individuals.
Second, the FOA emphasizes prediction in the acute post-trauma window. Applicants are expected to develop algorithms that can be applied soon after trauma exposure to predict which trajectory a patient is likely to follow. The intent is not prediction for its own sake, but to generate tools that could eventually inform targeted interventions, triage, and personalized follow-up. In other words, the platform should support the development of models that use early data to forecast later outcomes, ideally in a way that can be implemented in clinical workflows in emergency or acute care environments.
Administratively, this is a discretionary health research opportunity using the Cooperative Agreement mechanism (U01). A U01 signals that NIH anticipates substantial scientific involvement with the awardee compared to a typical investigator-initiated research grant, often including coordinated milestones, collaboration across sites, and active programmatic oversight to ensure the platform meets shared goals and produces broadly useful data. The FOA anticipated 1 award, with an estimated total funding amount of about $4,000,000, and an award ceiling listed at $13,300,000. There is no cost sharing or matching requirement.
The opportunity was posted June 12, 2015, with an original and final closing date of November 3, 2015, and an archive date of December 4, 2015. The CFDA number associated with the program is 93.242 (Mental Health Research Grants). While the announcement is archived now, the details reflect how NIH framed this initiative: building an integrated, multi-site longitudinal dataset and analytic framework centered on early post-trauma assessment, with the long-term goal of enabling earlier identification of risk and guiding future intervention development.
Eligibility was broad and included many types of domestic applicants, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, special district governments, and for-profit organizations (other than small businesses), as well as small businesses. The eligibility language also explicitly included a range of special categories, such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, certain federal agencies, and non-U.S. entities (foreign organizations). The sponsoring agency is NIH, and the full announcement was hosted on the NIH grants site at the link provided in the source material.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the Longitudinal Assessment of Post-traumatic Syndromes (U01) funding opportunity, identified as RFA-MH-16-500. It is an NIH cooperative agreement intended to support a single, large-scale, multi-site research platform focused on adult trauma patients.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of award mechanism is used?
The program uses the Cooperative Agreement mechanism (U01). A U01 indicates NIH expects substantial scientific involvement with the awardee, often including coordinated milestones, collaboration across sites, and active programmatic oversight.
How many awards were anticipated?
The FOA anticipated 1 award.
What is the estimated total funding amount?
The FOA listed an estimated total funding amount of about $4,000,000.
What is the award ceiling?
The award ceiling was listed as $13,300,000.
Is there any cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement.
What is the main purpose of the project being funded?
The core purpose is to build a longitudinal picture of how post-traumatic outcomes unfold by following adult trauma patients over time after they are first seen in emergency rooms or other acute trauma care settings. The platform is meant to combine real-world behavioral observations with biologically informed measures.
What population is the project focused on?
The initiative focuses on adult trauma patients, starting from their first contact with care in emergency departments or other acute trauma care environments.
Why does the FOA emphasize enrolling people at the point of acute care?
By focusing on patients in acute care settings soon after trauma exposure, the project aims to capture early indicators that may distinguish people who recover naturally from those who go on to develop persistent or worsening post-traumatic problems.
What are the main scientific goals described in the FOA?
The FOA describes two primary scientific goals: (1) characterizing different post-traumatic trajectories in a dimensional way over time, and (2) developing prediction approaches in the acute post-trauma window to forecast which trajectory a patient is likely to follow.
What does it mean to characterize post-traumatic trajectories "in a dimensional way"?
It means looking beyond simple yes/no diagnoses and instead examining patterns of symptoms, functioning, and biological changes over time, allowing for multiple forms and degrees of post-traumatic outcomes across individuals.
What kinds of measures or data streams does the FOA encourage?
The FOA encourages integrating multiple data streams, including clinical data, real-world behavioral observations, cognitive measures, neuroimaging or neurophysiology (where feasible), and biological sampling.
What examples of potential risk or recovery markers are mentioned?
Examples listed include neural network functional connectivity, cognitive functioning, emotion regulation capacity, and biomarkers related to immune response, along with other observable behavior and neurobiological changes.
What is meant by prediction in the acute post-trauma window?
Applicants are expected to develop algorithms that can be applied soon after trauma exposure (when patients present for acute care) to predict which post-traumatic trajectory a patient is likely to follow.
What is the intended use of the predictive algorithms described?
The intent is to generate tools that could eventually inform targeted interventions, triage, and personalized follow-up, ideally in ways that can be implemented in clinical workflows in emergency or acute care settings.
What type of research platform is NIH seeking to build through this award?
NIH is seeking a single, large-scale, multi-site longitudinal research platform that supports an integrated dataset and an analytic framework centered on early post-trauma assessment and follow-up over time.
What is the CFDA number associated with this program?
The CFDA number is 93.242, which corresponds to Mental Health Research Grants.
When was this opportunity posted?
The opportunity was posted on June 12, 2015.
What were the closing dates for submission?
The original and final closing date was November 3, 2015.
When was the archive date?
The archive date was December 4, 2015.
Is this opportunity currently open?
No. The announcement is described as archived, and the final closing date has passed.
Who was eligible to apply?
Eligibility was broad and included many types of domestic applicants such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, special district governments, for-profit organizations (other than small businesses), and small businesses.
Were any special categories of applicants explicitly included?
Yes. The eligibility language explicitly included Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, certain federal agencies, and non-U.S. entities (foreign organizations).
Does the FOA allow non-U.S. (foreign) organizations to apply?
Yes. The eligibility language explicitly includes non-U.S. entities (foreign organizations).
What is the long-term aim described for this initiative?
The long-term goal described is enabling earlier identification of risk after trauma and guiding future intervention development by building an integrated longitudinal dataset and analytic framework centered on early post-trauma assessment.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website at the link provided in the source material.
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