Longitudinal Study of a Population based Cohort of People with Lupus (U01) | Apply Online

Opportunity Summary:

The Centers for Disease Control and Prevention (CDC), through its Procurement and Grants Office, released a discretionary funding opportunity titled "Longitudinal Study of a Population based Cohort of People with Lupus (U01)" under Funding Opportunity Number RFA-DP-11-004. The award mechanism is a cooperative agreement (U01), which typically means the CDC expects to have substantial involvement in the project beyond simply providing funds, such as collaborating on study direction, coordination, or oversight. The program sits within the health activity category and is listed under CFDA 93.283 (CDC Investigations and Technical Assistance). The announcement was posted December 2, 2010, with an application deadline of March 4, 2011, and it was archived April 3, 2011. Applications were required to be submitted through Grants.gov and fully validated by 5:00 p.m. Eastern Time on the deadline date.

The core purpose of the opportunity is to support a new longitudinal research effort that follows an already established, population-based cohort of people with lupus over time. The cohort is expected to include individuals with systemic lupus erythematosus (SLE) and discoid lupus. Rather than building a new cohort from scratch, the emphasis is on leveraging an existing, well-defined population-based cohort and tracking participants prospectively (or through continued follow-up) to better understand how the disease unfolds and how outcomes change over time in real-world settings.

The study goals are centered on three major themes. First, the project is intended to characterize treatment patterns and health care access among cohort members, capturing how people are being managed clinically and what barriers or facilitators they face in receiving appropriate care. Second, it aims to document the natural history of lupus in this population-based sample, including outcomes tied to disease severity, morbidity, and mortality, as well as other indicators of disease burden that commonly evolve over time. Third, the project seeks to identify factors linked to those outcomes, including genetic contributors and other biological measures such as antibody levels. In other words, the CDC is looking for research that connects clinical trajectories and outcomes with underlying biological and potentially genetic markers, while also taking into account real-world treatment and access issues.

An important feature of the announcement is the expectation that findings will be examined across key categories of public health and research interest. The CDC specifically highlights subgroup analyses by demographics such as age, gender, and race/ethnicity, reflecting an interest in understanding disparities and differences in lupus outcomes and experiences across different populations. This aligns with the public health framing of lupus as a condition with heterogeneous presentation and uneven impacts across communities, where population-based data can be especially valuable for clarifying who is most affected, how disease progresses in different groups, and what factors may be driving gaps in outcomes.

In terms of funding, the announcement indicates that approximately $1,000,000 would be available in fiscal year 2011 to support 1 to 2 awards, while the overall estimated total funding is listed as $5,000,000. The award ceiling is stated as $750,000 (with an award floor of $0), and there is no cost-sharing or matching requirement, meaning applicants were not required to provide non-federal matching funds as a condition of the award. Eligibility is described as unrestricted (open to any type of entity), subject to any additional eligibility clarifications that may appear in the full announcement text.

For applicants needing help accessing the full announcement, the listed point of contact is the CDC Procurement and Grants Office Technical Information and Management Section (TIMS), reachable by phone at 770-488-2700, with a general CDC grants email referenced (though not fully shown in the excerpt).

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