Opportunity Information: Apply for RFA DP 14 004

  • The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Longitudinal Study of a Population based Cohort of People with Lupus" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283 Centers for Disease Control and PreventionInvestigations and Technical Assistance.
  • This funding opportunity was created on Feb 13, 2014 and posted on Feb 7, 2014.
  • Applicants must submit their applications by Mar 31, 2014 Key Dates Letter of Intent Due Date March 3, 2014, Application Due Date March 31, 2014, by 1159 PM U.S. Eastern Time. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
  • Section III. Eligibility Information 1. Eligible Applicants Eligible Organizations Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Institutions of Higher Education Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits (Other than Institutions of Higher Education) For Profit Organizations Small Businesses For Profit Organizations (Other than Small Businesses) Governments State Governments County Governments City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Other Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American tribal organizations (other than Federally recognized tribal governments) Faith based or Community based Organizations Regional Organizations Bona Fide Agents a Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If applying as a bona fide agent of a state or local government, a legal, binding agreement from the state or local government as documentation of the status is required. Attach with Other Attachment Forms when submitting via www.grants.gov. Federally Funded Research and Development Centers (FFRDCs) FFRDCs are operated, managed, and/or administered by a university or consortium of universities, other not for profit or nonprofit organization, or an industrial firm, as an autonomous organization or as an identifiable separate operating unit of a parent organization. A FFRDC meets some special long term research or development need which cannot be met as effectively by an agency s existing in house or contractor resources. FFRDCs enable agencies to use private sector resources to accomplish tasks that are integral to the mission and operation of the sponsoring agency. For more information on FFRDCs, go to http://ecfr.gpoaccess.gov/cgi/t/text/text idxcecfrsid512ff78311f427c00454772dcf21523argndiv8viewtextnode481.0.1.6.34.0.1.18idno48.
Apply for RFA DP 14 004

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Opportunity Summary:

The CDC grant opportunity titled "Longitudinal Study of a Population based Cohort of People with Lupus" (Funding Opportunity Number RFA-DP-14-004) was designed to fund public health research that tracks people living with lupus over time using an already established, population-based cohort in the United States. The main idea is straightforward but important: instead of relying on one-time snapshots of lupus patients, the CDC wanted applicants to follow a defined community-based group longitudinally so researchers can see how lupus changes across years, how care and treatments evolve, and which factors are tied to better or worse outcomes. The cohort of interest includes people of all ages and covers systemic lupus erythematosus (SLE) as well as skin lupus, reflecting an emphasis on capturing the broader lupus spectrum rather than only the most severe systemic cases.

The purpose of the study supported under this funding announcement centers on three major research aims. First, the CDC sought detailed, long-term information on treatment patterns, access to health care, and the natural history of lupus within the cohort. "Natural history" here includes tracking disease severity and progression, complications and morbidity, and mortality over time. Second, the announcement emphasized identifying factors associated with these outcomes, specifically calling out genetic and other biological contributors such as antibody levels, while leaving room for other relevant predictors that influence disease course. Third, the CDC highlighted the importance of analyzing all of the above through key demographic and equity lenses, including categories such as age, sex/gender, and race/ethnicity. This focus reflects the well-documented disparities in lupus burden and outcomes, where certain groups experience higher prevalence, more severe disease, and worse outcomes, yet where public health-oriented longitudinal data have historically been limited.

From a public health impact standpoint, the CDC framed this work as a way to uncover missed opportunities for improving treatment and care delivery, especially by identifying gaps in access or differences in management that could be addressed through interventions or policy changes. The longitudinal design also aims to help define new or refined lupus phenotypes based on how disease progresses over time, which can matter for both clinical decision-making and future research. By linking progression patterns to biological markers and other risk factors, the study could also point toward drivers of worsening disease that might be targets for secondary prevention (reducing complications and progression among those already diagnosed) and tertiary prevention (reducing disability and improving long-term functioning and quality of life).

Administratively, this was a discretionary grant program administered by the Centers for Disease Control and Prevention under CFDA 93.283 (CDC Investigations and Technical Assistance). The opportunity anticipated making three awards, with an estimated total funding amount of $15,000,000 and an award ceiling of $1,000,000 per award; there was no stated award floor. The funding instrument type was a grant, and there was no cost sharing or matching requirement. Key dates in the original posting included a letter of intent due March 3, 2014 and a full application due March 31, 2014 by 11:59 PM U.S. Eastern Time, with the opportunity later archived on April 30, 2014.

Eligibility was broad and covered a wide range of organization types, signaling that the CDC was open to strong applicants across academic, governmental, nonprofit, and private-sector settings as long as they could conduct or support the required longitudinal cohort work. Eligible applicants included public and private institutions of higher education (including institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native/Native Hawaiian-serving institutions), nonprofit organizations, for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district, tribal governments, U.S. territories/possessions, and eligible federal agencies). Other eligible entities included independent school districts, public housing authorities/Indian housing authorities, faith-based and community-based organizations, regional organizations, and federally funded research and development centers (FFRDCs). The announcement also allowed applications from bona fide agents acting on behalf of a state or local government, provided they submitted a legal, binding agreement documenting that status.

Notably, the FOA explicitly permitted foreign organizations to apply and allowed foreign components of U.S. organizations to participate, even though the cohort being followed was described as U.S.-based and population-based. In practical terms, that eligibility language suggests the CDC was willing to support international partners or institutions if they were meaningfully involved in analyzing data, contributing specialized laboratory or genetic work, or supporting study coordination, as long as the core cohort and its public health relevance remained anchored in the U.S. population-based framework.

For applicants seeking more information at the time, the announcement directed technical access questions to the CDC Procurement and Grants Office Technical Information Management Section (TIMS) via phone (770-488-2700) or email (pgotim@cdc.gov).

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number (FOA) for this CDC grant?

The opportunity is titled "Longitudinal Study of a Population based Cohort of People with Lupus" and the Funding Opportunity Number is RFA-DP-14-004.

Which federal agency offered this grant?

This was a discretionary grant program administered by the Centers for Disease Control and Prevention (CDC).

What CFDA program is associated with this opportunity?

The opportunity was listed under CFDA 93.283, "CDC Investigations and Technical Assistance."

What is the main goal of the funded study?

The study was designed to support public health research that follows (longitudinally) an already established, population-based cohort of people with lupus in the United States to understand how lupus changes over time, how treatment and care evolve, and what factors are linked to outcomes.

What does "longitudinal" mean in the context of this grant?

It means tracking the same defined community-based group of people with lupus over multiple years rather than relying on a one-time snapshot of patient status.

What type of cohort did applicants need to use?

The FOA focused on an already established, population-based cohort in the United States. The intent was to follow a defined community-based group over time.

Which lupus populations were included?

The cohort of interest included people of all ages and covered systemic lupus erythematosus (SLE) as well as skin lupus, reflecting an emphasis on capturing a broader lupus spectrum.

What were the major research aims supported by this funding announcement?

The FOA described three major aims: (1) collect detailed long-term information on treatment patterns, access to health care, and the natural history of lupus in the cohort; (2) identify factors associated with outcomes, including genetic and other biological contributors (such as antibody levels) and other relevant predictors; and (3) analyze the findings through key demographic and equity lenses including age, sex/gender, and race/ethnicity.

What kinds of outcomes and "natural history" elements were the CDC looking to track?

"Natural history" in the FOA included tracking disease severity and progression, complications and morbidity, and mortality over time.

Did the FOA emphasize health equity or disparities?

Yes. The CDC specifically highlighted analyzing treatment, access, and outcomes by demographic categories such as age, sex/gender, and race/ethnicity, reflecting known disparities in lupus burden and outcomes.

What kinds of factors did the FOA mention as potentially influencing outcomes?

The FOA specifically called out genetic and other biological contributors (including antibody levels) and also allowed for other relevant predictors tied to disease course.

What public health impact did the CDC associate with this research?

The CDC framed the work as a way to identify missed opportunities for improving treatment and care delivery by uncovering gaps in access or differences in management that could be addressed through interventions or policy changes.

How could longitudinal findings be used beyond describing trends?

The FOA noted that longitudinal data could help define new or refined lupus phenotypes based on progression patterns and link those patterns to biological markers and other risk factors, potentially pointing toward drivers of worsening disease that may be targets for prevention efforts.

What prevention concepts were mentioned in the FOA?

The announcement referenced secondary prevention (reducing complications and progression among those already diagnosed) and tertiary prevention (reducing disability and improving long-term functioning and quality of life).

What type of funding instrument was used?

The funding instrument type was a grant.

How many awards did the CDC anticipate making?

The opportunity anticipated making three awards.

What was the estimated total funding amount?

The estimated total funding amount was $15,000,000.

What was the maximum award amount (award ceiling)?

The award ceiling was $1,000,000 per award.

Was there a minimum award amount (award floor)?

No award floor was stated in the information provided.

Was cost sharing or matching required?

No. The FOA stated there was no cost sharing or matching requirement.

Who was eligible to apply?

Eligibility was broad and included public and private institutions of higher education, nonprofit organizations, for-profit organizations (including small businesses), and multiple levels of government (including state, county, city/township, special district, tribal governments, U.S. territories/possessions, and eligible federal agencies). The FOA also listed independent school districts, public housing authorities/Indian housing authorities, faith-based and community-based organizations, regional organizations, and federally funded research and development centers (FFRDCs).

Were specific types of colleges and universities explicitly included?

Yes. The FOA included institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native/Native Hawaiian-serving institutions among eligible higher education applicants.

Could a for-profit organization apply?

Yes. For-profit organizations, including small businesses, were listed as eligible applicants.

Could a faith-based or community-based organization apply?

Yes. Faith-based and community-based organizations were included among eligible entities.

Could a federally funded research and development center (FFRDC) apply?

Yes. FFRDCs were listed as eligible applicants.

Are foreign organizations allowed to apply?

Yes. The FOA explicitly permitted foreign organizations to apply.

Are foreign components of U.S. organizations allowed to participate?

Yes. The announcement allowed foreign components of U.S. organizations to participate.

If the cohort is U.S.-based, why would foreign eligibility matter?

The FOA described a U.S.-based, population-based cohort, but the foreign eligibility language suggests international partners could still participate in meaningful ways (for example, analysis support, specialized laboratory or genetic work, or coordination), as long as the core cohort and public health relevance remained anchored in the U.S. population-based framework.

Could an agent apply on behalf of a state or local government?

Yes. Applications from bona fide agents acting on behalf of a state or local government were allowed, provided they submitted a legal, binding agreement documenting that status.

What were the key due dates for the original posting?

The letter of intent was due March 3, 2014. The full application was due March 31, 2014 by 11:59 PM U.S. Eastern Time.

When was the opportunity archived?

The opportunity was archived on April 30, 2014.

Who should applicants contact for technical access questions?

Technical access questions were directed to the CDC Procurement and Grants Office Technical Information Management Section (TIMS) at 770-488-2700 or pgotim@cdc.gov.

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