Opportunity Information: Apply for EPA G2016 STAR B1
Apply for EPA G2016 STAR B1
- The EPA in the environment sector is offering a public funding opportunity titled "Long-term Exposure to Air Pollution and Development of Cardiovascular Disease" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509.
- This funding opportunity was created on May 18, 2016 and posted on May 18, 2016.
- Applicants must submit their applications by Aug 02, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The U.S. Environmental Protection Agency (EPA) announced this discretionary grant opportunity through its Science to Achieve Results (STAR) program to support research on how long-term exposure to air pollution contributes to the development of cardiovascular disease. The central focus is on clarifying the biological and physiological mechanisms that connect air pollution exposures to cardiovascular harm, moving beyond broad associations to a more detailed, mechanistic understanding that can strengthen risk estimates and inform public health and regulatory decisions.
A major priority is improving estimates of the total cardiovascular risk attributable to air pollution. The EPA is looking for projects that consider not only the well-established outcomes commonly used in epidemiology and public health (such as cardiovascular morbidity and mortality), but also earlier, subtler indicators of harm. This includes measures of subclinical cardiovascular damage that may appear before clinically diagnosed disease, as well as novel endpoints that could reveal additional pathways or types of injury not captured by traditional outcomes. The intent is to better characterize the full spectrum of cardiovascular impacts across different stages of disease development.
The solicitation also highlights related health endpoints that overlap with cardiovascular disease biology and risk. In particular, the EPA calls for research that examines markers of cardio-metabolic responses, recognizing that metabolic dysfunction and inflammation-related processes often intersect with cardiovascular disease pathways. In addition, the opportunity explicitly mentions cerebrovascular disease, signaling interest in outcomes related to blood vessels and circulation in the brain, which can include conditions such as stroke and other vascular brain injuries linked to long-term environmental exposures.
Another key element is data accessibility. The EPA notes the implications of this research for public policy and references federal expectations around open access to data from publicly funded research. As a result, applicants are encouraged to develop innovative methods that make the data generated through these projects broadly accessible. This emphasis suggests the agency is not only funding scientific discovery, but also seeking approaches that improve transparency, reproducibility, and the ability of other researchers or stakeholders to use the resulting datasets for further analysis and validation.
Administratively, this is an EPA STAR grant with Funding Opportunity Number EPA G2016 STAR B1 under CFDA 66.509 (environment-related assistance). The opportunity anticipated a single award, with an award ceiling of $3,000,000. The original and current application deadline was August 2, 2016, and the announcement was posted May 18, 2016. Eligibility is listed broadly as "Others," with the specific details intended to be clarified in the full eligibility text associated with the announcement.
Frequently Asked Questions (FAQs)
What is this EPA grant opportunity about?
This is a U.S. Environmental Protection Agency (EPA) discretionary research grant opportunity under the Science to Achieve Results (STAR) program. It supports research on how long-term exposure to air pollution contributes to the development of cardiovascular disease, with a central emphasis on understanding the biological and physiological mechanisms linking exposure to harm.
What is the main scientific focus of the solicitation?
The main focus is moving beyond broad statistical associations and toward a clearer mechanistic understanding of how air pollution causes cardiovascular harm. The goal is to strengthen risk estimates and support public health and regulatory decision-making with more detailed evidence about causal pathways.
What does the EPA mean by "mechanistic understanding" in this context?
Based on the announcement, "mechanistic understanding" refers to clarifying the biological and physiological processes that connect long-term air pollution exposures to cardiovascular damage and disease development, rather than only documenting that exposure and disease are correlated.
What priority does the EPA place on cardiovascular risk estimation?
A major priority is improving estimates of the total cardiovascular risk attributable to air pollution. The EPA is looking for projects that help better quantify the full burden of cardiovascular effects linked to air pollution exposure.
Are traditional endpoints like cardiovascular morbidity and mortality still relevant for this grant?
Yes. The solicitation notes these are well-established outcomes commonly used in epidemiology and public health. However, the EPA also wants applicants to go beyond these traditional endpoints to capture earlier and potentially broader indicators of harm.
What kinds of "earlier" or "subtler" indicators of harm are encouraged?
The opportunity encourages measurement of subclinical cardiovascular damage that may occur before clinically diagnosed disease. It also encourages novel endpoints that could reveal additional pathways or types of injury not captured by traditional outcomes.
What are "novel endpoints" in the context of this opportunity?
As described in the solicitation, novel endpoints are measures that may identify cardiovascular-related injury pathways or effects that are not captured by standard outcomes like morbidity and mortality, helping to characterize a broader spectrum of impacts across disease development.
Does the solicitation include health endpoints beyond cardiovascular disease?
Yes. The announcement highlights related endpoints that overlap with cardiovascular biology and risk, including cardio-metabolic responses and cerebrovascular disease.
What does the EPA mean by "cardio-metabolic responses" here?
The solicitation calls for research examining markers of cardio-metabolic responses, recognizing that metabolic dysfunction and inflammation-related processes often intersect with cardiovascular disease pathways.
Is cerebrovascular disease included in the research scope?
Yes. The opportunity explicitly mentions cerebrovascular disease, indicating interest in outcomes related to blood vessels and circulation in the brain, including conditions such as stroke and other vascular brain injuries linked to long-term environmental exposures.
Why is data accessibility emphasized in this opportunity?
The EPA notes implications for public policy and references federal expectations around open access to data from publicly funded research. Applicants are encouraged to develop innovative methods to make data generated through funded projects broadly accessible, supporting transparency, reproducibility, and reuse.
Does the EPA require open access to the data?
From the information provided, the EPA "encourages" applicants to develop methods to make data broadly accessible and cites federal expectations around open access. Specific requirements would be defined in the related policy language and full announcement materials referenced by the EPA.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is EPA G2016 STAR B1.
What program is this grant offered under?
This is offered under the EPA Science to Achieve Results (STAR) program and is described as a discretionary grant opportunity.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 66.509 (environment-related assistance).
How many awards were anticipated?
The opportunity anticipated a single award.
What is the maximum funding amount for the award?
The award ceiling listed is $3,000,000.
When was the opportunity posted?
The announcement was posted on May 18, 2016.
What was the application deadline?
The original and current application deadline was August 2, 2016.
Who is eligible to apply?
Eligibility is listed broadly as "Others." The announcement indicates that specific eligibility details are intended to be clarified in the full eligibility text associated with the opportunity.
What is the intended impact of the funded research?
The intended impact is to improve understanding of how long-term air pollution exposure contributes to cardiovascular disease through biological mechanisms, improve total risk estimation (including subclinical and novel endpoints), and produce data that can support public health and regulatory decisions and broader scientific reuse.
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