Opportunity Information: Apply for PAR 07 420
Apply for PAR 07 420
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "Lymphatic Biology in Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.837 Cardiovascular Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 27, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Lymphatic Biology in Health and Disease (R01) opportunity (Funding Opportunity Number PAR-07-420) is a National Institutes of Health grant announcement led by the National Heart, Lung, and Blood Institute (NHLBI). Its central aim is to push forward research that explains how the lymphatic system works in both normal physiology and across a wide range of diseases, while also encouraging studies that point to new therapeutic possibilities. The program is broadly framed to invite projects that examine lymphatic biology at any scale, from molecular and cellular mechanisms through tissue and organ function, up to whole-body and systems-level physiology. In addition to foundational biology, the announcement also emphasizes innovation in how lymphatic diseases are identified, monitored, prevented, or treated, and it explicitly welcomes work relevant to all age groups and many different disease states rather than restricting the topic to a single condition.
Funding is provided through the NIH Research Project Grant mechanism (R01), which is the standard NIH vehicle for investigator-driven, hypothesis-based research projects. The announcement does not set a fixed budget cap or a guaranteed number of awards; instead, awards depend on the availability of funds and the volume of strong, competitive applications received. Because projects can vary widely in scope and complexity, both the size of each award and the project period are expected to vary as well. In practical terms, applicants are expected to propose a budget and timeline that match the scientific goals, and NHLBI will make final award decisions based on scientific merit, program priorities, and available appropriations.
Eligibility is intentionally broad and includes many types of organizations. Domestic applicants can include public or state-controlled and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, and other for-profit organizations (beyond small businesses), as well as state and local government entities. The FOA also allows participation by U.S. territories and possessions, tribal governments (federally recognized and other than federally recognized), and tribally designated organizations. It further highlights eligibility for historically underserved or mission-driven institutions and organizations such as Hispanic-serving institutions, historically Black colleges and universities (HBCUs), tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian-serving institutions, along with regional organizations. Importantly, non-U.S. (foreign) organizations are eligible to apply, and eligible federal agencies may also submit applications. Faith-based and community-based organizations are explicitly included as eligible applicant types, which signals the announcement is open to a wide range of institutional settings as long as the applicant can credibly conduct the proposed research.
On the investigator side, the opportunity is open to any qualified Project Director/Principal Investigator (PD/PI) with the expertise and resources needed to carry out the work, working through an eligible institution or organization. NIH also reiterates its longstanding encouragement for applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities. The announcement allows applicants to submit more than one application as long as each submission is scientifically distinct, which can be useful for teams pursuing multiple independent lines of lymphatic research. It also permits multiple PDs/PIs on a single application, enabling multi-disciplinary or multi-lab leadership structures when a project benefits from shared oversight. Resubmissions are allowed, but they must include an Introduction that directly addresses the prior peer review critique, responding to issues raised in the Summary Statement.
Administratively, the FOA is categorized as discretionary funding and uses the grant funding instrument type. It lists CFDA numbers associated with several research areas, including nursing research, cardiovascular diseases research, and child health and human development extramural research, reflecting the cross-cutting relevance of lymphatic biology to many NIH missions and disease domains. There is no cost sharing or matching requirement. The opportunity was originally posted July 27, 2007 (with a listed creation date of December 5, 2008), and it used multiple receipt dates rather than a single deadline, meaning applications were accepted on several standard NIH submission cycles during the active period of the announcement. The record also shows an archive date of October 19, 2009, indicating it is no longer an active open solicitation under that specific listing, though similar NHLBI and NIH lymphatic biology funding opportunities may exist under newer announcements.
For applicants seeking the official details, the full announcement was linked through the NIH Grants Guide at the provided URL, and NIH Office of Extramural Research (OER) webmaster contact information was supplied for technical access or linking problems.
Frequently Asked Questions (FAQs): Lymphatic Biology in Health and Disease (R01) - PAR-07-420
1) What is the name of this funding opportunity and who leads it?
The opportunity is titled Lymphatic Biology in Health and Disease (R01) with Funding Opportunity Number PAR-07-420. It is a National Institutes of Health (NIH) grant announcement led by the National Heart, Lung, and Blood Institute (NHLBI).
2) What is the main purpose of PAR-07-420?
The central aim is to advance research that explains how the lymphatic system functions in normal physiology and across a wide range of diseases, while encouraging studies that could point to new therapeutic possibilities.
3) What research topics or scientific scope does the FOA encourage?
The announcement is broadly framed and invites projects examining lymphatic biology at many scales, including molecular and cellular mechanisms, tissue and organ function, and whole-body/systems-level physiology.
4) Is the focus limited to one disease or one patient population?
No. The FOA explicitly welcomes work relevant to all age groups and many different disease states rather than restricting the topic to a single condition.
5) Does the FOA encourage translational or clinically relevant work?
Yes. In addition to foundational biology, the announcement emphasizes innovation in how lymphatic diseases are identified, monitored, prevented, or treated.
6) What type of NIH award mechanism is used?
Funding is offered through the NIH Research Project Grant (R01) mechanism, which is NIH's standard vehicle for investigator-driven, hypothesis-based research projects.
7) Is there a fixed budget cap or a guaranteed number of awards?
No. The announcement does not set a fixed budget cap and does not guarantee a number of awards. Awards depend on availability of funds and the number of strong, competitive applications received.
8) How should applicants think about the project period and budget size?
Because projects can vary widely in scope and complexity, the award size and project period are expected to vary. Applicants are expected to propose a budget and timeline that match the scientific goals, and NHLBI makes final decisions based on scientific merit, program priorities, and available appropriations.
9) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
10) What types of organizations are eligible to apply (U.S. domestic applicants)?
Eligibility is broad and includes: public or state-controlled and private institutions of higher education; nonprofits (with or without 501(c)(3) status); small businesses; other for-profit organizations (beyond small businesses); and state and local government entities.
11) Are U.S. territories, tribal entities, and tribally designated organizations eligible?
Yes. The FOA allows participation by U.S. territories and possessions, tribal governments (federally recognized and other than federally recognized), and tribally designated organizations.
12) Are mission-driven and historically underserved institutions highlighted as eligible?
Yes. The FOA highlights eligibility for organizations such as Hispanic-serving institutions, historically Black colleges and universities (HBCUs), tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and regional organizations.
13) Can faith-based or community-based organizations apply?
Yes. Faith-based and community-based organizations are explicitly included among eligible applicant types.
14) Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA states that non-U.S. (foreign) organizations are eligible to apply.
15) Can federal agencies submit applications?
Yes. The FOA notes that eligible federal agencies may submit applications.
16) Who can serve as Project Director/Principal Investigator (PD/PI)?
The opportunity is open to any qualified PD/PI with the expertise and resources needed to conduct the proposed research, working through an eligible institution or organization.
17) Does NIH encourage applications from underrepresented groups or individuals with disabilities?
Yes. NIH reiterates its encouragement for applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities.
18) Can an applicant submit more than one application?
Yes. Applicants may submit more than one application as long as each submission is scientifically distinct.
19) Are multiple PDs/PIs allowed on a single application?
Yes. The FOA permits multiple PDs/PIs on a single application, supporting multi-disciplinary or multi-lab leadership structures when shared oversight makes sense for the project.
20) Are resubmissions allowed, and is anything special required?
Yes. Resubmissions are allowed, but they must include an Introduction that directly addresses the prior peer review critique and responds to issues raised in the Summary Statement.
21) What type of funding is this (administrative classification)?
The FOA is categorized as discretionary funding and uses the grant funding instrument type.
22) Are any CFDA numbers mentioned, and what do they indicate?
Yes. The FOA lists CFDA numbers associated with several research areas, including nursing research, cardiovascular diseases research, and child health and human development extramural research. This reflects that lymphatic biology is considered cross-cutting and relevant to multiple NIH missions and disease domains.
23) When was this FOA posted, and is it still active?
The opportunity was originally posted on July 27, 2007 (with a listed creation date of December 5, 2008). The record shows an archive date of October 19, 2009, indicating it is no longer an active open solicitation under that specific listing.
24) Did this FOA use a single deadline or multiple receipt dates?
It used multiple receipt dates rather than a single deadline, meaning applications were accepted on several standard NIH submission cycles during the active period of the announcement.
25) Where can applicants find the official announcement and who is listed for technical help?
The full announcement was linked through the NIH Grants Guide at the provided URL, and NIH Office of Extramural Research (OER) webmaster contact information was supplied for technical access or linking problems.
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