Lymphatics in Health and Disease in the Digestive System, Kidney, and Urinary Tract (R01) | Apply Online

Opportunity Summary:

PAR-15-306, titled "Lymphatics in Health and Disease in the Digestive System, Kidney, and Urinary Tract (R01)," is a National Institutes of Health (NIH) discretionary grant opportunity that uses the Research Project Grant (R01) mechanism to support investigator-initiated research focused on lymphatic vessels in specific organ systems. The central goal is to stimulate studies that clarify how lymphatic vessels develop, how they are built and organized locally within tissues (functional anatomy), how they work under normal conditions (physiology), and how they change or malfunction in disease (pathophysiology) within the digestive system, the kidney, and the urinary tract. A key boundary of the program is that projects whose major emphasis is on immune mechanisms are not encouraged; the program is steering applicants toward lymphatic vessel biology and function as they relate directly to organ physiology and organ dysfunction, rather than primarily immunology-driven questions.

The scientific scope is aimed at filling gaps in understanding of the local factors that shape lymphatic vessel structure and performance in these organs, both during health and during injury or chronic disease. This includes research on the signals and conditions that control lymphatic vessel growth, remodeling, permeability, contractility, fluid handling, and transport functions, as well as studies that connect lymphatic alterations to downstream consequences for organ performance. The FOA is also interested in mechanistic work that explains how changes in lymphatic vessel function can influence disease onset, progression, or recovery in the gastrointestinal tract and associated digestive organs, in renal tissues, and throughout the urinary tract. In practical terms, the opportunity targets proposals that can link lymphatic vessel dysfunction to measurable impacts on organ-level outcomes such as fluid balance, tissue edema, interstitial pressure, waste clearance, nutrient or lipid transport where relevant, and other physiologic processes that matter for digestive and kidney/urinary tract health.

From an applicant and administrative standpoint, this is a grant (not a contract) with no cost sharing or matching requirement. The listed award ceiling is $250,000, indicating the opportunity is structured with a funding cap as presented in the source data. The program is associated with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting the institute mission area most closely aligned with the topic. The funding activity category is labeled under food and nutrition health, consistent with the digestive system component and broader health framing, while still explicitly encompassing kidney and urinary tract research.

Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include small businesses, for-profit entities (including those other than small businesses), and multiple types of nonprofit organizations, including 501(c)(3) nonprofits and non-501(c)(3) nonprofits (with the noted exceptions around institutions of higher education in the listing). Public and private institutions of higher education are included, as are independent school districts and many government entities such as state governments, county governments, and city or township governments, plus special district governments and public/Indian housing authorities. The eligibility description also explicitly extends to many mission-driven and underserved-serving institution categories and community-based organizational types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Tribal organizations are included both as federally recognized tribal governments and other tribal governments, and the opportunity also allows foreign organizations and other non-U.S. entities, regional organizations, and U.S. territories or possessions, which signals NIH interest in enabling the best science regardless of geography when appropriate to the research aims.

The timeline information in the source indicates the FOA was posted and created on July 24, 2015, with an original and current closing date of September 7, 2018, and an archive date of October 8, 2018. That means the specific announcement as listed is no longer active for new submissions under that exact FOA, but it remains useful as a statement of NIH priorities in this area and as a reference point for locating any reissued or related opportunities. The official NIH announcement page is provided at http://grants.nih.gov/grants/guide/pa-files/PAR-15-306.html, which is where applicants would have found full submission instructions, review criteria, and detailed scientific interest areas when the FOA was open.

For help accessing or linking to the full announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, which is an administrative support contact rather than a scientific program contact.

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