Opportunity Information: Apply for PAR 12 259
Apply for PAR 12 259
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jul 24, 2015 and posted on Aug 8, 2012.
- Applicants must submit their applications by Jul 24, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Small businesses Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments Public housing authorities/Indian housing authorities Private institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity PAR 12-259, titled "Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01)," supports Research Project Grant (R01) applications that investigate how lymphatic vessels function in both normal physiology and disease across several major organ systems. The main scientific aim is to deepen understanding of lymphatic vessel biology in the digestive tract and urinary organs, as well as in the cardiovascular and pulmonary systems, particularly in contexts where lymphatic function may influence outcomes such as inflammation, tissue fluid balance, and recovery from thromboembolic events. The announcement is geared toward projects that clarify what drives organ-specific lymphatic structure and function, how lymphatic vessels adapt or fail during disease, and how those lymphatic changes translate into altered organ performance.
A central theme of the FOA is the relationship between local lymphatic vessel functional anatomy and physiology and organ health. In practice, this means the NIH is looking for studies that define the local factors shaping lymphatic networks within specific tissues (for example, the gut, kidney/urinary tract, lungs, or cardiovascular tissues), and how those networks behave under stress or injury. Projects can focus on mechanisms that alter lymphatic transport, vessel permeability, pumping/contractility, remodeling, or interactions with surrounding tissue environments. The FOA also highlights interest in lymphatics as part of disease processes and recovery, including their roles in resolving thromboembolic events and in shaping inflammatory responses, as long as the primary emphasis is not on immune mechanisms alone.
An important boundary in this opportunity is responsiveness: proposals that are mainly focused on immune mechanisms are not considered responsive to the announcement. While inflammation and immune responses are mentioned as relevant disease contexts, the grant is intended to prioritize lymphatic vessel physiology and pathophysiology itself rather than projects centered on immunology as the dominant scientific question. In other words, immune-related endpoints can be included, but the core hypothesis and experimental design should be driven by lymphatic vessel function, structure, regulation, or dysfunction and how those lymphatic changes affect organ outcomes.
From an administrative and eligibility standpoint, this is a discretionary grant opportunity using the NIH R01 mechanism. It was posted on August 8, 2012, and later archived in 2015 (with an archive date of August 24, 2015), meaning it is no longer an active solicitation in its original form, but it remains useful as a reference for the NIH priorities at the time and for understanding how similar current NIH lymphatics-related opportunities may be framed. The listed award ceiling is $250,000 (as provided in the source data), and there is no cost sharing or matching requirement.
Eligibility is broad and includes many types of U.S. and non-U.S. applicants. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), state and local governments (state, county, city/township, special district), independent school districts, public housing authorities/Indian housing authorities, Native American tribal governments (federally recognized and other than federally recognized), and various mission-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Foreign institutions are also eligible to apply, and foreign components of U.S. organizations are allowed, consistent with NIH policy definitions.
The opportunity is associated with multiple NIH-related research areas and CFDA numbers spanning cardiovascular, lung, blood, and digestive/kidney research: 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), 93.839 (Blood Diseases and Resources Research), and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The full archived announcement is linked through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-12-259.html, and the NIH Office of Extramural Research (OER) webmaster contacts are provided for access or technical issues with the posting.
FAQs: NIH PAR-12-259 - Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01)
What is PAR-12-259?
PAR-12-259 is an NIH Funding Opportunity Announcement (FOA) titled "Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01)." It supported Research Project Grant (R01) applications focused on how lymphatic vessels function in normal physiology and how they contribute to disease processes across several organ systems.
What grant mechanism does this opportunity use?
This opportunity used the NIH Research Project Grant (R01) mechanism.
What is the main scientific focus of the FOA?
The FOA emphasizes lymphatic vessel biology and function in the digestive tract, urinary organs, cardiovascular system, and pulmonary system. The goal is to improve understanding of organ-specific lymphatic structure and function, how lymphatics adapt or fail during disease, and how those changes affect organ outcomes.
Which organ systems are included in the scope of this FOA?
The FOA specifically highlights the digestive system, urinary organs/urinary tract, cardiovascular tissues, and the lungs/pulmonary system.
What types of research questions are considered responsive?
Responsive projects are those driven by lymphatic vessel function and pathophysiology, including questions about what determines organ-specific lymphatic structure and function, how lymphatic networks change during stress, injury, or disease, and how lymphatic changes translate into altered organ performance.
What aspects of lymphatic biology does the FOA highlight?
The FOA highlights studies on mechanisms that alter lymphatic transport, vessel permeability, pumping/contractility, remodeling, and interactions between lymphatic vessels and their surrounding tissue environments, particularly within specific organs.
Does the FOA allow studies involving inflammation?
Yes. Inflammation is listed as a relevant disease context, especially where lymphatic function may influence outcomes such as inflammatory responses and tissue fluid balance. However, the project must remain centered on lymphatic vessel physiology/pathophysiology rather than immunology as the primary scientific driver.
Are projects mainly focused on immune mechanisms considered responsive?
No. A key boundary in this FOA is that proposals mainly focused on immune mechanisms are not considered responsive. Immune-related endpoints can be included, but the core hypothesis and experimental design should be driven by lymphatic vessel structure, function, regulation, or dysfunction and the effects on organ outcomes.
What outcomes or disease contexts are mentioned as relevant to lymphatic function?
The FOA notes contexts where lymphatic function may influence inflammation, tissue fluid balance, and recovery from thromboembolic events, provided the primary emphasis remains on lymphatic vessel physiology and pathophysiology.
What does the FOA mean by "local lymphatic vessel functional anatomy and physiology"?
It refers to how the structure and functional behavior of lymphatic vessels within a specific tissue or organ (for example, gut, kidney/urinary tract, lungs, or cardiovascular tissues) relate to organ health, including how local tissue factors shape lymphatic networks and how those networks behave during stress or injury.
Is this an active funding opportunity?
No. The FOA was posted on August 8, 2012 and later archived on August 24, 2015. That means it is no longer an active solicitation in its original form, though it can still be used as a reference for NIH priorities at the time and for how similar opportunities may be framed.
When was the FOA posted and when was it archived?
It was posted on August 8, 2012 and archived on August 24, 2015.
What is the listed award ceiling for this opportunity?
The listed award ceiling is $250,000 (as provided in the source data).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); state and local governments (including state, county, city/township, and special districts); independent school districts; public housing authorities/Indian housing authorities; Native American tribal governments (federally recognized and other than federally recognized); and various mission-focused institutions and organizations such as HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible?
Yes. Foreign institutions are eligible to apply, and foreign components of U.S. organizations are allowed, consistent with NIH policy definitions.
Which NIH/CFDA research areas are associated with this FOA?
The FOA is associated with CFDA numbers 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), 93.839 (Blood Diseases and Resources Research), and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Where can someone find the archived FOA text?
The archived announcement is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-12-259.html.
Who is listed for help with access or technical issues related to the posting?
The opportunity indicates that NIH Office of Extramural Research (OER) webmaster contacts are provided for access or technical issues with the posting.
Browse more opportunities from the same category: Food and Nutrition Health
Next opportunity: Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21)
Previous opportunity: New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 12 259
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 12 259) also looked into and applied for these:
| Funding Opportunity |
|---|
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Advancing Clinical Research in Primary Glomerular Diseases (UM1) Apply for RFA DK 12 014 Funding Number: RFA DK 12 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Novel Interventions to Reduce Morbidity and Mortality of Hemodialysis Patients Safety and Other Early Phase Studies (U01) Apply for RFA DK 12 010 Funding Number: RFA DK 12 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program Apply for RFA DK 12 013 Funding Number: RFA DK 12 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $600,000 |
| Limited Competition Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 12 285 Funding Number: PAR 12 285 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $50,000 |
| George M. OBrien Urology Cooperative Research Centers Program (U54) Apply for RFA DK 12 009 Funding Number: RFA DK 12 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $650,000 |
| Ancillary Studies of Acute Kidney Injury, Chronic Kidney Disease, and End Stage Renal Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases (R01) Apply for PA 12 299 Funding Number: PA 12 299 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Early Stage Pharmacological Validation of Novel Targets and Accompanying Pre Therapeutic Leads for Diseases of Interest to the NIDDK (R01) Apply for PAR 13 007 Funding Number: PAR 13 007 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| New Directions in Hematology Research (SHINE II) (R01) Apply for PAS 13 006 Funding Number: PAS 13 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4) Apply for RFA DK 12 510 Funding Number: RFA DK 12 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Research Using Biosamples from Selected Type 1 Diabetes Clinical Studies (DP3) Apply for PAR 13 013 Funding Number: PAR 13 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20) Apply for RFA DK 12 022 Funding Number: RFA DK 12 022 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Nociceptive GenitoUrinary Development Molecular Anatomy Projects (nGUDMAP) (U01) Apply for RFA DK 12 024 Funding Number: RFA DK 12 024 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Research Using Subjects From Selected Type 1 Diabetes Clinical Studies (Living Biobank) (DP3) Apply for PAR 13 028 Funding Number: PAR 13 028 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Stimulating Hematology Investigation New Endeavors (SHINE) (R01) Apply for PAS 13 031 Funding Number: PAS 13 031 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 12 259", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.