Opportunity Information: Apply for RFA HL 11 004
Apply for RFA HL 11 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "MAPGen Knowledge Base (MAPGenKB) and Coordination Center (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Mar 4, 2010 and posted on Mar 3, 2010.
- Applicants must submit their applications by Sep 1, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- Eligible applicants include: City or township governments Special district governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The MAPGen Knowledge Base (MAPGenKB) and Coordination Center (U01) opportunity (Funding Opportunity Number RFA HL 11 004) is an NIH/NHLBI funding announcement focused on building the central infrastructure for a larger research program called MAPGen for HLBS, short for the Consortium of Cross Organ Mechanism Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases. In practical terms, this award is meant to create a combined knowledge base and coordinating hub that supports multiple MAPGen Research Centers working on genetic analyses and phenotypes that cut across organ systems (heart, lung, blood, and sleep). It is one of two companion announcements for the overall MAPGen program; the other FOA funds the Research Centers themselves (RFA HL 11 005), while this FOA funds the shared backbone that helps the whole consortium function and produce integrated, reusable outputs.
The core purpose of the MAPGenKB is twofold: coordination and informatics/knowledge synthesis. On the coordination side, the center is expected to provide logistical support across all participating Research Centers, which typically includes organizing consortium activities, enabling consistent procedures, supporting communication, and helping keep multi-site work aligned. On the informatics side, it is expected to develop and implement a Knowledge Base that can collect, organize, and integrate data coming from the Research Centers, and also bring in other relevant sources that help meet MAPGen goals. A key emphasis is on synthesizing knowledge from consortium datasets rather than simply warehousing files. This implies building usable structures such as curated datasets, harmonized variables, documentation, metadata, and analytical or browsing tools that allow researchers to connect genetic information with phenotypes spanning multiple organ-related disease areas.
A major program expectation is broad dissemination. The announcement makes clear that the data and tools generated through the consortium are intended to be made available to the wider scientific community. That usually points to a deliverable-oriented project where the end products are not only internal systems for the consortium, but also externally accessible resources (for example, data releases, searchable databases, documentation, and software or analytic utilities) that other investigators can use to accelerate discovery beyond the original MAPGen teams.
This FOA uses the Cooperative Agreement (U01) mechanism, which signals a substantial level of NIH scientific or programmatic involvement compared with a standard research grant. In a U01 structure, NHLBI typically has an active partnership role in coordinating activities, setting milestones, and ensuring that consortium-wide goals, data sharing expectations, and governance processes are met. For applicants, that generally means proposing clear management plans, well-defined deliverables, and an approach that can operate effectively in a multi-center, multi-stakeholder environment.
Funding is described as up to an estimated total of $5.5 million, contingent on available funds and the presence of sufficiently strong applications, with an anticipated single award supporting a five-year project period. The listing also includes an award ceiling of $650,000 (as presented in the source information), and the program planned to support one coordinating center rather than multiple parallel centers. The original posting dates were in early March 2010, with an application closing date of September 1, 2010, and an archive date of October 2, 2010.
Eligibility is broad and includes many types of U.S.-based organizations, spanning public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), small businesses and other for-profit organizations (with distinctions noted), and multiple levels of government (state, county, city/township, special districts), as well as tribal governments and tribal organizations. The eligibility text also explicitly calls out additional institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. There is no cost sharing or matching requirement listed. The activity falls under NIH health-related categories and references CFDA areas connected to sleep disorders, cardiovascular, lung, and blood research (93.233, 93.837, 93.838, 93.839), reflecting the cross-cutting HLBS scope of the consortium.
Overall, this opportunity is best understood as a consortium infrastructure award: it is not primarily aimed at running a single hypothesis-driven research project, but at enabling, coordinating, integrating, and distributing the data and knowledge products that come from multiple MAPGen Research Centers, with the explicit goal of creating shared resources that continue to support the broader biomedical research community.
FAQs: MAPGen Knowledge Base (MAPGenKB) and Coordination Center (U01) - RFA HL 11 004
What is this funding opportunity?
This is an NIH/NHLBI Funding Opportunity Announcement (FOA) for the MAPGen Knowledge Base (MAPGenKB) and Coordination Center using the U01 Cooperative Agreement mechanism. The FOA is identified as RFA HL 11 004.
What does MAPGen for HLBS stand for?
MAPGen for HLBS refers to the Consortium of Cross Organ Mechanism Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases.
What is the main purpose of the MAPGenKB and Coordination Center award?
The award is intended to create the central infrastructure for the MAPGen consortium by combining (1) consortium-wide coordination support and (2) an informatics-driven Knowledge Base that synthesizes, organizes, and integrates data and knowledge coming from multiple MAPGen Research Centers and other relevant sources.
How does this FOA fit into the larger MAPGen program?
This FOA funds the shared backbone (the Knowledge Base and coordinating hub) that helps the overall MAPGen consortium function and produce integrated, reusable outputs. It is one of two companion announcements; the other companion FOA funds the MAPGen Research Centers themselves (RFA HL 11 005).
Is this award meant to support a single research project?
No. This opportunity is best understood as a consortium infrastructure award. Its focus is on enabling, coordinating, integrating, and distributing the data and knowledge products produced by multiple MAPGen Research Centers, rather than running a single hypothesis-driven research study.
What are the two core functions expected of the MAPGenKB?
The FOA describes two major functions:
- Coordination: Providing logistical support across participating Research Centers, such as organizing consortium activities, supporting communication, enabling consistent procedures, and keeping multi-site work aligned.
- Informatics and knowledge synthesis: Developing and implementing a Knowledge Base that collects, organizes, and integrates data from the Research Centers and incorporates other relevant sources to meet MAPGen goals.
What does it mean that the Knowledge Base should emphasize knowledge synthesis rather than just warehousing files?
It means the Knowledge Base is expected to go beyond storing data. The emphasis is on making the data usable and integrative through structures such as curated datasets, harmonized variables, documentation, metadata, and analytical or browsing tools that help connect genetic information with phenotypes spanning heart, lung, blood, and sleep disease areas.
What kinds of outputs or deliverables are implied for the Knowledge Base?
Based on the FOA description, outputs commonly include curated and integrated datasets, harmonized variables, metadata and documentation, and tools that allow researchers to browse, analyze, and connect genetic information with cross-organ phenotypes. The FOA also signals externally accessible resources such as data releases, searchable databases, documentation, and software or analytic utilities.
How important is data and tool dissemination in this program?
Broad dissemination is a major expectation. The FOA states that data and tools generated through the consortium are intended to be made available to the wider scientific community, indicating that the end products should support use beyond the original MAPGen teams.
What funding mechanism is used and what does it imply?
The FOA uses the U01 Cooperative Agreement mechanism. This implies a substantial level of NIH/NHLBI scientific or programmatic involvement compared with a standard research grant, typically including active partnership in coordinating activities, setting milestones, and ensuring consortium-wide goals, data sharing expectations, and governance processes are met.
What does NHLBI involvement usually mean for applicants under a U01?
In a U01 structure, applicants generally need to propose clear management plans, well-defined deliverables, and an approach designed to operate effectively in a multi-center, multi-stakeholder consortium environment, consistent with NHLBI's active coordinating role described in the FOA.
How many awards were planned under this announcement?
The program was planned to support a single coordinating center (one award), rather than multiple parallel centers.
What is the project period for the award?
The FOA anticipated a five-year project period for the single award.
How much funding is available under this FOA?
Funding is described as up to an estimated total of $5.5 million, contingent on available funds and the presence of sufficiently strong applications. The source information also lists an award ceiling of $650,000.
Is cost sharing or matching required?
No cost sharing or matching requirement is listed in the provided opportunity information.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations, including:
- Public and private institutions of higher education
- Nonprofits, including 501(c)(3) and other nonprofit structures
- Small businesses and other for-profit organizations (with distinctions noted)
- State, county, city/township governments, and special district governments
- Tribal governments and tribal organizations
- U.S. territories or possessions
- Regional organizations
- Faith-based or community-based organizations
- Institution types explicitly called out such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions
What scientific areas does this program cover?
The program is focused on genetic analyses and phenotypes that cut across organ systems, specifically heart, lung, blood, and sleep diseases, reflecting the cross-cutting HLBS scope of the MAPGen consortium.
Are there referenced CFDA areas associated with this opportunity?
Yes. The opportunity references CFDA areas connected to sleep disorders and cardiovascular, lung, and blood research: 93.233, 93.837, 93.838, and 93.839.
What were the key dates for this FOA?
The original posting dates were in early March 2010. The application closing date was September 1, 2010. The archive date was October 2, 2010.
What is the relationship between the Coordination Center and the MAPGen Research Centers?
The Coordination Center is expected to support multiple MAPGen Research Centers by organizing consortium activities, enabling consistent procedures, supporting communication, and keeping multi-site efforts aligned. It also integrates and synthesizes the data coming from those Research Centers into the MAPGen Knowledge Base.
What distinguishes this coordinating center from the Research Centers funded under the companion FOA?
The companion FOA (RFA HL 11 005) funds the MAPGen Research Centers that generate consortium data through their research. This FOA (RFA HL 11 004) funds the shared infrastructure that coordinates those centers and turns their collective outputs into integrated, reusable knowledge products and community-facing resources.
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