Opportunity Information: Apply for PA 09 193
Apply for PA 09 193
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.866 Aging Research.
- This funding opportunity was created on Dec 20, 2012 and posted on May 28, 2009.
- Applicants must submit their applications by Dec 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Small businesses Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses County governments State governments City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity PA 09 193, titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R01)," supports research aimed at improving how pain is understood, measured, and treated in older adults. The central idea is that pain in later life is shaped by a mix of biological aging processes, age-related diseases, changes in the nervous system, and psychosocial factors, and that older adults may be underserved by pain tools and interventions originally designed and validated in younger populations. This announcement invites R01 projects that can clarify why pain presents differently with age, how common it is across older groups, and what can be done to assess and manage it more effectively in real-world clinical settings.
The FOA highlights four broad areas of interest. First, it encourages studies on mechanisms, meaning the biological, neurobiological, psychosocial, and clinical processes through which aging and age-related disease influence pain. This can include work ranging from molecular and cellular pathways to brain and nervous system changes, to how comorbidities, medications, and functional decline interact with pain. Second, it seeks research on factors that affect pain experience and prevalence in older people, again across biological and psychosocial domains, which could include vulnerability and resilience factors, differences across subgroups of older adults, and contributors such as inflammation, neurodegeneration, mood, cognition, and social context. Third, it supports evaluation of existing pain assessment or management approaches specifically in older adults, recognizing that standard pain scales, diagnostic approaches, and common treatments may not perform the same way in aging populations or in those with sensory, cognitive, or communication limitations. Fourth, it invites development of new pain assessment methods and/or new management strategies designed with older adults in mind, with attention to needs that are especially relevant in aging, such as multimorbidity, polypharmacy risk, frailty, dementia, disability, and care settings like long-term care.
A key feature is the wide methodological scope: both animal model studies and human subjects research are considered appropriate. That flexibility allows applicants to propose basic, translational, or clinical research, as long as the work clearly advances understanding or improves practice around pain in aging. Projects can span the continuum "from molecular to clinical," which signals that the NIH is interested in anything from mechanistic lab studies that may reveal new targets to pragmatic evaluations of assessment tools or interventions in older patient populations.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is typically suited for mature, hypothesis-driven projects with a defined research plan and sufficient preliminary support. It is part of a coordinated set of announcements with the same scientific scope, paired with an R21 version (PA 09 194) for exploratory or developmental work and an R03 version (PA 09 195) for smaller projects. In other words, the NIH is funding the same overall theme at multiple project sizes, and applicants are expected to choose the mechanism that best matches the stage, scale, and risk level of the proposed research.
Funding levels and the number of awards are not fixed in the announcement. Instead, NIH notes that award size and duration will vary depending on the nature and scope of the applications received, and that the total amount awarded and the number of awards will depend on factors like the number of submissions, scientific merit, project duration, and requested costs. There is no cost sharing or matching requirement.
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), various levels of government (state, county, city/township), independent school districts, special district governments, and public housing/Indian housing authorities. The FOA explicitly includes a wide range of mission-focused institutions and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other tribal organizations and governments, as well as faith-based and community-based organizations. It also allows non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, reflecting an interest in diverse settings and populations relevant to aging and pain.
Administratively, the sponsoring agency is the National Institutes of Health, and the opportunity is categorized as a discretionary grant in the health area. The CFDA program areas connected to the announcement include 93.866 (Aging Research) and 93.213 (Research and Training in Complementary and Integrative Health), which signals potential interest in a wide range of scientifically grounded approaches to pain in older adults, including but not limited to conventional biomedical strategies. The original posting date listed is May 28, 2009, with later administrative dates indicating the announcement was active through 2012 and then archived in January 2013. The full announcement was hosted on the NIH grants guide site under the PA 09 193 listing, and NIH provided contacts via the NIH Office of Extramural Research web support for access or linking issues.
FAQs: NIH PA-09-193 - Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R01)
What is NIH PA-09-193?
PA-09-193 is a National Institutes of Health (NIH) funding opportunity announcement titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R01)." It supports research that improves how pain is understood, measured, and treated in older adults.
What is the main goal of this funding opportunity?
The goal is to advance research on pain in later life by improving scientific understanding of why pain may present differently with age, how common it is across groups of older adults, and what can be done to assess and manage it more effectively in real-world clinical settings.
Why is this FOA focused specifically on older adults?
The FOA emphasizes that pain in later life is influenced by biological aging processes, age-related diseases, nervous system changes, and psychosocial factors. It also notes that older adults may be underserved by pain tools and interventions that were originally designed and validated in younger populations.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is generally intended for mature, hypothesis-driven projects with a defined research plan and sufficient preliminary support.
Are there related NIH opportunities for smaller or earlier-stage projects?
Yes. NIH described this R01 as part of a coordinated set of announcements with the same scientific scope, including an R21 version (PA-09-194) for exploratory/developmental work and an R03 version (PA-09-195) for smaller projects.
What research topics are encouraged under this FOA?
The FOA highlights four broad areas of interest: (1) mechanisms of pain in aging, (2) factors that affect pain experience and prevalence in older adults, (3) evaluation of existing pain assessment or management approaches in older adults, and (4) development of new pain assessment methods and/or new management strategies designed for older adults.
What does the FOA mean by studying "mechanisms" of pain in aging?
Mechanisms research can include biological, neurobiological, psychosocial, and clinical processes through which aging and age-related disease influence pain. The FOA indicates this can span molecular and cellular pathways, brain and nervous system changes, and interactions among comorbidities, medications, functional decline, and pain.
What kinds of "factors affecting pain experience and prevalence" are within scope?
The FOA points to factors across biological and psychosocial domains, including vulnerability and resilience factors, differences across subgroups of older adults, and contributors such as inflammation, neurodegeneration, mood, cognition, and social context.
Does this FOA support evaluation of existing pain assessments and treatments in older adults?
Yes. A specific emphasis is evaluating existing pain assessment or management approaches in older adults, recognizing that standard pain scales, diagnostic approaches, and common treatments may not perform the same way in aging populations or in people with sensory, cognitive, or communication limitations.
Does this FOA support creating new tools or interventions for pain in older adults?
Yes. The FOA invites development of new pain assessment methods and/or management strategies designed with older adults in mind, including attention to issues such as multimorbidity, polypharmacy risk, frailty, dementia, disability, and care settings such as long-term care.
Does the NIH require projects to be clinical, or can they be basic science?
The FOA indicates a wide methodological scope. Both animal model studies and human subjects research are considered appropriate, and projects can span basic, translational, or clinical research as long as they clearly advance understanding or improve practice around pain in aging.
What does "from molecular to clinical" signal about acceptable project scope?
It signals that NIH is interested in research across the continuum, from mechanistic lab studies that may reveal new targets to pragmatic evaluations of assessment tools or interventions in older patient populations.
Are funding levels, project duration, or number of awards specified?
No. The FOA states that award size and duration will vary depending on the nature and scope of the applications received, and that the total amount awarded and number of awards will depend on factors such as the number of submissions, scientific merit, project duration, and requested costs.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and various levels of government.
What types of government entities are eligible?
The FOA includes state, county, and city/township governments, independent school districts, special district governments, and public housing/Indian housing authorities as eligible applicants.
Are community-based, faith-based, and mission-focused institutions included?
Yes. The FOA explicitly includes faith-based and community-based organizations, and it also names multiple categories of mission-focused institutions and communities, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, other tribal organizations and governments, and related entities.
Can non-U.S. organizations apply?
Yes. The FOA allows non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, reflecting an interest in diverse settings and populations relevant to aging and pain.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
How is this opportunity categorized?
It is categorized as a discretionary grant in the health area.
Which CFDA program areas are connected to this FOA?
The FOA lists CFDA 93.866 (Aging Research) and 93.213 (Research and Training in Complementary and Integrative Health). This signals potential interest in a wide range of scientifically grounded approaches to pain in older adults, including but not limited to conventional biomedical strategies.
When was this FOA posted, and is it still active?
The original posting date listed is May 28, 2009. The administrative dates indicate it was active through 2012 and then archived in January 2013.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants guide website under the PA-09-193 listing.
Where did NIH direct users for technical help accessing or linking to the announcement?
NIH provided contacts via the NIH Office of Extramural Research web support for access or linking issues.
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