Opportunity Information: Apply for PA 09 195
Apply for PA 09 195
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Dec 20, 2012 and posted on May 28, 2009.
- Applicants must submit their applications by Dec 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Small businesses For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R03)" invites proposals for small, focused research projects that improve how pain is understood, measured, and treated in older adults. The central idea is that pain in later life is often shaped by aging itself and by age-related diseases, yet the mechanisms behind those changes, and the best ways to assess and manage pain in older people, still need clearer evidence. This FOA is built to support early-stage or tightly scoped studies that can generate practical findings, refine methods, or produce preliminary data that could later support a larger grant.
The scope of research the FOA is looking for is broad, but it is organized around four main directions. First, applicants can study the biological, neurobiological, psychosocial, and clinical mechanisms through which aging and/or age-related conditions influence the experience of pain. That can include molecular and cellular processes, nervous system changes, and the ways chronic illness or functional decline interacts with pain pathways. Second, applicants can examine factors that affect pain prevalence and pain experience among older adults, again spanning biological and neurobiological contributors as well as psychosocial and clinical influences such as comorbidities, medications, mental health, cognition, social context, and healthcare access. Third, the FOA supports projects that evaluate existing pain assessment tools and/or pain management approaches specifically in older populations, recognizing that methods validated in younger adults may not perform the same way in older people due to differences in physiology, cognition, communication, or disease burden. Fourth, it encourages development of new pain assessment methods and/or management strategies that directly account for the needs and realities of older adults, which could include improved measurement tools, tailored interventions, or new clinical approaches better suited to aging populations.
Methodologically, the announcement allows both animal model studies and human-subjects research, reflecting an interest in translation across the full continuum from molecular mechanisms to clinical practice. The grant mechanism is the NIH Small Research Grant (R03), which is meant for smaller projects that can be completed relatively quickly with limited resources. The FOA explicitly notes that appropriate R03 project types include pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, development of research methodology, and development of new research technology. In practice, this means the program is well-suited for investigators who want to test a promising idea, validate a measure in an older cohort, explore mechanisms using a targeted experimental design, or generate preliminary data to support a later R01 or other larger-scale study.
From an administrative standpoint, this is a discretionary grant opportunity in the health category, listed under CFDA 93.866 (Aging Research), and it does not require cost sharing or matching. Eligibility is intentionally expansive: it includes state, county, city/township, and special district governments; public and private institutions of higher education; nonprofits both with and without 501(c)(3) status (with certain conditions); small businesses and other for-profit organizations; independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations. The eligibility details also explicitly include a wide range of mission-specific and community-linked institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and even non-U.S. (foreign) entities and regional organizations. The broad eligibility aligns with the FOA's practical goal of improving pain research in aging through diverse research settings and populations.
Key dates in the source record indicate the FOA was posted May 28, 2009, with an original closing date of September 7, 2012, a current closing date listed as December 21, 2012, and an archive date of January 21, 2013. In other words, the specific listing provided is archived, but it still serves as a clear statement of NIH research priorities and the kinds of R03 projects NIH has sought in this topic area. Applicants looking for the full original announcement were directed to the NIH Grants Guide page (PA-09-195), and technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity about?
This NIH Funding Opportunity Announcement (FOA), titled "Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R03)," supports small, focused research projects aimed at improving how pain in older adults is understood, measured, and treated. The FOA emphasizes that pain in later life is often shaped by biological aging and age-related diseases, and it seeks studies that clarify mechanisms, strengthen assessment, and improve management approaches specifically for older populations.
What grant mechanism is used for this opportunity?
The FOA uses the NIH Small Research Grant mechanism (R03). R03 awards are intended for smaller projects that can be completed relatively quickly with limited resources, often to test ideas, refine methods, or generate preliminary findings that could support a later, larger grant.
What kinds of projects are considered a good fit for an R03 under this FOA?
The FOA explicitly highlights the following as appropriate R03 project types: pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, development of research methodology, and development of new research technology.
What is the overall research focus of the FOA?
The FOA focuses on pain in aging, with an emphasis on how aging itself and age-related conditions influence pain mechanisms, how pain should be measured in older adults, and how pain should be managed in ways that account for the realities of older populations (including differences in physiology, cognition, communication, and disease burden).
What are the main research directions or topic areas supported?
The FOA is organized around four main directions: (1) mechanisms by which aging and/or age-related conditions influence pain (biological, neurobiological, psychosocial, and clinical mechanisms); (2) factors affecting pain prevalence and pain experience among older adults (including comorbidities, medications, mental health, cognition, social context, and healthcare access); (3) evaluation of existing pain assessment tools and/or pain management approaches in older populations; and (4) development of new pain assessment methods and/or new/tailored management strategies designed specifically for older adults.
Does the FOA allow both basic science and clinical research?
Yes. The FOA allows studies using animal models as well as human-subjects research, reflecting interest in translation across the full continuum from molecular mechanisms to clinical practice.
Is the FOA limited to studies of pain mechanisms only?
No. In addition to mechanisms, the FOA also supports research on measurement (assessment tools and methods) and management (interventions and clinical approaches), including evaluation of existing approaches and development of new ones tailored to older adults.
Why does the FOA emphasize older adults specifically?
The FOA notes that approaches validated in younger adults may not perform the same way in older people due to differences such as physiology, cognition, communication, or higher disease burden. The goal is to build clearer evidence that directly reflects older populations.
What types of influences on pain in older adults are mentioned as relevant?
The FOA references a wide range of influences, including biological and neurobiological contributors, psychosocial and clinical influences, comorbidities, medication use, mental health, cognition, social context, and healthcare access.
Can a project focus on improving or validating pain assessment tools for older adults?
Yes. One of the core directions is evaluating existing pain assessment tools in older populations, and another is developing new assessment methods that account for older adults' needs and realities.
Can a project focus on improving pain management approaches for older adults?
Yes. The FOA supports evaluation of existing pain management approaches in older adults and encourages development of new management strategies or tailored interventions better suited to aging populations.
Is this opportunity considered a health-related discretionary grant?
Yes. It is described as a discretionary grant opportunity in the health category.
What CFDA number is associated with this opportunity?
The FOA is listed under CFDA 93.866, which is identified as Aging Research.
Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching.
Who is eligible to apply?
Eligibility is described as broad and includes: state, county, city/township, and special district governments; public and private institutions of higher education; nonprofits (with or without 501(c)(3) status, with certain conditions); small businesses and other for-profit organizations; independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations.
Are community-linked and mission-specific institutions included in eligibility?
Yes. The eligibility details explicitly include institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility list explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) entities allowed to apply?
Yes. The eligibility details explicitly include non-U.S. (foreign) entities and regional organizations.
Are federal agencies eligible?
Yes. The eligibility details explicitly mention eligible federal agencies.
What is the status of the specific listing described here?
The key dates provided indicate the listing is archived. The archive date is January 21, 2013, and the record shows earlier closing dates in 2012, which means this specific listing is no longer active as a current application target.
What were the key dates shown for this FOA record?
The record indicates the FOA was posted May 28, 2009, with an original closing date of September 7, 2012, a current closing date listed as December 21, 2012, and an archive date of January 21, 2013.
Where were applicants directed to find the full original announcement?
Applicants were directed to the NIH Grants Guide page for PA-09-195.
Where were technical access issues directed?
Technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact.
What is the practical goal of supporting small, tightly scoped studies in this area?
The FOA frames the R03 as a way to generate practical findings, refine methods, or produce preliminary data that could later support a larger grant (such as an R01) while still producing evidence that helps improve pain research and outcomes in aging populations.
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Previous opportunity: Mechanisms, Measurement, and Management of Pain in Aging from Molecular to Clinical (R21)
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