Opportunity Information: Apply for RFA AG 11 006
Apply for RFA AG 11 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 3, 2010 and posted on Aug 3, 2010.
- Applicants must submit their applications by Oct 14, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Private institutions of higher education State governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute on Aging (NIA) funding opportunity titled "Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01)" (Funding Opportunity Number RFA-AG-11-006) supports research aimed at explaining how the brain and related neuroendocrine systems influence bone metabolism across aging. The central idea behind the announcement is that bone health is not controlled only by local bone cells or circulating hormones in the traditional sense; it is also shaped by signals that originate in the brain and travel through neural and hormonal pathways to regulate bone formation and bone resorption. NIA is looking for R01 research projects that can clarify the mechanisms behind age-dependent changes in these brain-to-bone regulatory systems, with an emphasis on how those mechanisms may contribute to changes in bone mass over time and the development or progression of osteoporosis.
A key scientific driver for this FOA is the influential finding that leptin, a hormone secreted by fat cells (adipocytes), can regulate bone mass through a central relay involving serotonergic neurons. That discovery opened up a broader set of questions that this program wants investigators to tackle, especially questions about what other neural mediators connect the brain to skeletal physiology and how those mediators change with age. The announcement highlights multiple candidate pathways and factors of interest, including serotonin and other hypothalamic or neural factors, as well as endocrine signals such as TSH and FSH, signaling families like ephrins, opioid-related peptides like dynorphins, endocannabinoids and their receptors, and pituitary or adrenal-related factors such as ACTH. The FOA also explicitly encourages consideration of cross-talk with distant organs and tissues, with adipose tissue called out as an example, reflecting the idea that bone is part of a broader, integrated physiology involving metabolism, endocrine signaling, and neural control.
In addition to chemical signaling, the FOA notes emerging evidence that direct innervation of bone matters for how bone senses mechanical load and remodels itself. This is important because mechanical loading is one of the major determinants of bone strength, and understanding how nerves participate in load sensing and remodeling could reshape how researchers think about fracture risk and age-related bone loss. Because neuroendocrine activity is known to change substantially with age, NIA views this research area as likely to revise the field's understanding of why bone mass increases or decreases over the lifespan and how age-related dysregulation might lead to osteoporosis. Projects responsive to this announcement would typically aim to identify and characterize age-related shifts in relevant neural, endocrine, immune, or other integrative pathways, and to map the "coordination logic" that links these systems to skeletal outcomes.
From a funding and administrative standpoint, this opportunity uses the NIH Research Project Grant (R01) mechanism. NIA anticipated making 3 to 5 awards, with budgets up to $250,000 per year in direct costs, and project periods of up to 5 years, contingent on the availability of funds and the quality of applications. The estimated total funding listed is $1.5 million. There is no cost sharing or matching requirement. The funding activity category is health, under CFDA 93.866 (Aging Research). The opportunity was posted August 3, 2010, with an original and current closing date of October 14, 2010, and an archive date of November 14, 2010, meaning it was a time-limited solicitation that is now archived.
Eligibility was broad and included many types of domestic and non-domestic entities. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses) as well as small businesses, and multiple levels of government (state, county, city/township, special district, and certain housing authorities). It also included tribal governments and tribal organizations, tribally controlled colleges and universities, and designated serving institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, along with faith-based and community-based organizations. Importantly, the eligibility list also included foreign (non-U.S.) organizations and U.S. territories or possessions, indicating NIA’s willingness to consider strong projects regardless of whether the applicant is domestic, as long as NIH policies are met.
Overall, this FOA is best summarized as a targeted NIA initiative to fund mechanistic, integrative biology research that explains how central nervous system pathways, neuroendocrine changes, and inter-organ signaling networks drive age-related changes in bone mass, bone remodeling, and osteoporosis risk, using the standard R01 framework with moderate-sized annual direct cost budgets and a limited number of awards.
Frequently Asked Questions (FAQs)
What is the title of this NIH/NIA funding opportunity?
The funding opportunity is titled "Mechanisms Mediating Changes in Central Regulation of Bone Mass (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AG-11-006.
Which NIH institute is sponsoring this opportunity?
This opportunity is sponsored by the NIH National Institute on Aging (NIA).
What grant mechanism does this opportunity use?
It uses the NIH Research Project Grant (R01) mechanism.
What is the main purpose of this FOA?
The purpose is to support research that explains how the brain and related neuroendocrine systems influence bone metabolism across aging, including how age-dependent changes in brain-to-bone regulatory systems contribute to changes in bone mass and to osteoporosis development or progression.
What core scientific idea is motivating this announcement?
The FOA is built around the idea that bone health is not controlled only by local bone cells or circulating hormones in a traditional sense. Instead, it is also shaped by signals that originate in the brain and travel through neural and hormonal pathways to regulate bone formation and bone resorption.
What types of research projects are considered responsive to this FOA?
Projects are expected to clarify mechanisms behind age-dependent changes in central (brain-mediated) regulation of bone mass. Responsive projects would typically aim to identify and characterize age-related shifts in relevant neural, endocrine, immune, or other integrative pathways, and to map the coordination logic linking these systems to skeletal outcomes such as bone mass, remodeling, and osteoporosis risk.
Is the focus specifically on aging?
Yes. The FOA emphasizes age-dependent changes in neuroendocrine activity and central regulation, with the goal of improving understanding of why bone mass changes across the lifespan and how age-related dysregulation may lead to osteoporosis.
What discovery is highlighted as a key scientific driver for this program?
The FOA highlights the influential finding that leptin (a hormone secreted by adipocytes) can regulate bone mass through a central relay involving serotonergic neurons, which raised broader questions about additional neural mediators and how they change with age.
Does this FOA require research on leptin?
The FOA uses leptin and serotonergic neuron findings as a key driver and example, and it encourages work on other mediators as well. It is framed as an opening to broader mechanistic questions about brain-to-bone regulation and aging.
What neural or hypothalamic factors are mentioned as candidates of interest?
The FOA mentions serotonin and other hypothalamic or neural factors as candidates of interest in mediating central regulation of skeletal physiology.
What endocrine signals are specifically called out in the announcement?
The announcement calls out endocrine signals such as TSH and FSH, and also references pituitary or adrenal-related factors such as ACTH.
What other signaling families or molecules are highlighted as relevant?
The FOA highlights signaling families and molecules including ephrins, opioid-related peptides such as dynorphins, and endocannabinoids and their receptors.
Does the FOA encourage studying interactions between bone and other organs?
Yes. It explicitly encourages consideration of cross-talk with distant organs and tissues, and it specifically calls out adipose tissue as an example, reflecting an integrated physiology linking metabolism, endocrine signaling, neural control, and skeletal outcomes.
Is direct innervation of bone within the scope of this FOA?
Yes. The FOA notes emerging evidence that direct innervation of bone may be important for how bone senses mechanical load and remodels itself, and it highlights this as an important consideration for understanding bone strength and age-related bone loss.
How does mechanical loading relate to the research priorities described?
The FOA points out that mechanical loading is a major determinant of bone strength and suggests that understanding how nerves participate in load sensing and remodeling could reshape thinking about fracture risk and age-related bone loss.
What health condition is emphasized as an outcome or risk tied to these mechanisms?
The FOA emphasizes osteoporosis, including how central regulatory dysregulation with age may contribute to osteoporosis development or progression.
How many awards did NIA anticipate making under this FOA?
NIA anticipated making 3 to 5 awards, contingent on availability of funds and the quality of applications.
What is the maximum budget allowed per award?
Budgets were allowed up to $250,000 per year in direct costs.
What is the maximum project period?
Project periods could be up to 5 years.
What was the estimated total funding for the program?
The estimated total funding listed is $1.5 million.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the funding activity category and CFDA number?
The funding activity category is health. The CFDA number is 93.866 (Aging Research).
When was this opportunity posted?
The opportunity was posted on August 3, 2010.
What was the closing date for applications?
The original and current closing date listed is October 14, 2010.
Is this funding opportunity still open?
No. The FOA is described as time-limited and is now archived. It has an archive date of November 14, 2010.
Who was eligible to apply?
Eligibility was broad and included many types of domestic and non-domestic entities, including public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses) and small businesses, and multiple levels of government.
Which government entities were included in eligibility?
Eligible government entities included state, county, city/township, special district, and certain housing authorities.
Were tribal entities eligible to apply?
Yes. Tribal governments and tribal organizations were included, as well as tribally controlled colleges and universities.
Were designated serving institutions eligible (HBCUs, HSIs, etc.)?
Yes. The eligibility list included designated serving institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and other listed serving institutions.
Were faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were included in the eligibility list.
Could foreign organizations apply?
Yes. The eligibility list explicitly included foreign (non-U.S.) organizations.
Were U.S. territories or possessions eligible?
Yes. The eligibility list included U.S. territories or possessions.
How would you summarize this FOA in plain terms?
It is a targeted NIA initiative to fund mechanistic, integrative biology research explaining how central nervous system pathways, neuroendocrine changes, and inter-organ signaling networks drive age-related changes in bone mass, bone remodeling, and osteoporosis risk, using the R01 framework with moderate-sized annual direct-cost budgets and a limited number of awards.
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