Opportunity Information: Apply for PA 12 019
Apply for PA 12 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms Mediating Osteoarthritis in Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Nov 22, 2011 and posted on Nov 22, 2011.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Mechanisms Mediating Osteoarthritis in Aging (R01) (Funding Opportunity Number PA 12-019) was a National Institutes of Health discretionary grant opportunity that supported health-related research projects using the NIH R01 research project grant mechanism. It was jointly issued by the National Institute on Aging (NIA) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), reflecting an emphasis on how aging biology intersects with osteoarthritis (OA) development and progression. The central purpose of the announcement was to encourage and speed up research that clarifies the mechanisms that drive osteoarthritic progression in the context of aging, with a particular push toward characterizing new or underused experimental and analytical models and using those models to test well-formed mechanistic hypotheses.
Scientifically, the opportunity focused on advancing an improved, mechanism-level understanding of why and how osteoarthritis progresses as organisms age. Rather than limiting applicants to conventional approaches, the announcement explicitly highlighted the value of developing, validating, and applying new or underutilized models relevant to osteoarthritis in aging. In practical terms, this could include innovative animal models, tissue or organ culture systems, engineered cartilage or joint models, computational or systems-biology frameworks, or other emerging platforms that make it possible to probe disease mechanisms more precisely. The underlying expectation was that stronger models and rigorous hypothesis testing would illuminate the biological processes mediating OA progression, potentially identifying pathways and targets that could inform future interventions, prevention strategies, or translational studies.
From an administrative standpoint, this was a grant (not a contract) and fell under the broad NIH health research activity category. It was associated with CFDA numbers 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and 93.866 (Aging Research). There was no cost-sharing or matching requirement, which is typical for many NIH research grants. The announcement was posted on November 22, 2011, and it ultimately closed on January 7, 2015, with an archive date of February 7, 2015, meaning it is no longer accepting applications under that specific announcement.
Eligibility was intentionally broad and inclusive. Eligible applicants included a wide range of U.S. entities such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district), as well as independent school districts and public housing authorities/Indian housing authorities. The eligibility language also made clear that a number of mission-driven institution types could apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Importantly, non-U.S. entities were eligible as well: foreign institutions could apply, non-domestic components of U.S. organizations were eligible, and foreign components (as defined in NIH policy) were allowed, which signaled NIH interest in enabling the best-fit expertise and resources regardless of geography when justified.
For applicants and readers seeking official details during the active period, NIH provided the full announcement via the NIH Grants Guide (linked at http://grants.nih.gov/grants/guide/pa-files/PA-12-019.html). NIH also listed support contacts through the NIH Office of Extramural Research (OER) webmaster channels for access or linking issues, which is standard for NIH postings. Overall, the opportunity can be summarized as an NIH R01 call designed to deepen the field's mechanistic understanding of osteoarthritis progression in aging by promoting rigorous hypothesis-driven work and accelerating the adoption or development of models that better capture the aging-related biology underlying OA.
Frequently Asked Questions (FAQs)
What is the "Mechanisms Mediating Osteoarthritis in Aging (R01)" opportunity (PA-12-019)?
Mechanisms Mediating Osteoarthritis in Aging (R01) (Funding Opportunity Number PA-12-019) was a National Institutes of Health (NIH) discretionary grant opportunity that supported health-related research projects using the NIH R01 Research Project Grant mechanism. It emphasized research on how aging biology intersects with osteoarthritis (OA) development and progression.
Which NIH institutes issued this funding opportunity?
The opportunity was jointly issued by the National Institute on Aging (NIA) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This joint issuance reflected a focus on osteoarthritis progression specifically in the context of aging.
What was the main goal of PA-12-019?
The central purpose was to encourage and accelerate research that clarifies the mechanisms driving osteoarthritic progression in the context of aging. A key emphasis was on characterizing new or underused experimental and analytical models and using those models to test well-formed mechanistic hypotheses.
What kind of science did the announcement encourage?
PA-12-019 focused on advancing a mechanism-level understanding of why and how osteoarthritis progresses as organisms age. It encouraged rigorous, hypothesis-driven studies that leverage stronger or more relevant models to illuminate biological processes mediating OA progression.
Did the opportunity limit applicants to conventional osteoarthritis research approaches?
No. The announcement explicitly highlighted the value of developing, validating, and applying new or underutilized models relevant to osteoarthritis in aging, rather than restricting applicants to conventional approaches.
What types of models were highlighted as potentially relevant?
The opportunity described a range of possible platforms, including innovative animal models, tissue or organ culture systems, engineered cartilage or joint models, computational approaches, systems-biology frameworks, and other emerging platforms that enable more precise probing of disease mechanisms.
What was the expectation behind developing or using better models?
The expectation was that improved or better-matched models, paired with rigorous hypothesis testing, would help reveal the biological processes that mediate OA progression in aging. These insights could potentially identify pathways and targets that inform future interventions, prevention strategies, or translational studies.
Was this a grant or a contract?
This opportunity was a grant (not a contract) under the NIH health research activity category.
What funding mechanism was used?
The opportunity used the NIH R01 Research Project Grant mechanism.
What were the associated CFDA numbers?
The opportunity was associated with CFDA 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and CFDA 93.866 (Aging Research).
Was cost-sharing or matching required?
No. The announcement stated there was no cost-sharing or matching requirement, which is typical for many NIH research grants.
When was PA-12-019 posted?
The announcement was posted on November 22, 2011.
Is PA-12-019 still accepting applications?
No. The opportunity closed on January 7, 2015, and had an archive date of February 7, 2015. That means it is no longer accepting applications under this specific announcement.
Who was eligible to apply?
Eligibility was broad. Eligible applicants included U.S. public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district). Independent school districts and public housing authorities/Indian housing authorities were also eligible.
Were mission-driven or special institution types explicitly included?
Yes. The eligibility language explicitly included institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Could non-U.S. organizations apply?
Yes. The eligibility language indicated that foreign institutions could apply, non-domestic components of U.S. organizations were eligible, and foreign components (as defined in NIH policy) were allowed.
Where could applicants find the official announcement details?
During the active period, the full announcement was available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-12-019.html.
Did NIH provide any support contacts related to the posting?
Yes. NIH listed support contacts through NIH Office of Extramural Research (OER) webmaster channels for access or linking issues, which is standard for NIH postings.
How can this opportunity be summarized in one sentence?
PA-12-019 was an NIH R01 call from NIA and NIAMS aimed at deepening mechanistic understanding of osteoarthritis progression in aging by promoting rigorous hypothesis-driven research and accelerating the development or adoption of models that better capture aging-related OA biology.
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