Opportunity Information: Apply for PA 07 282
Apply for PA 07 282
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Mechanisms, Models, Measurement, and Management in Pain Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.223 Development and Coordination of Rural Health Services 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.395 Cancer Treatment Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Sep 4, 2009 and posted on Jan 8, 2007.
- Applicants must submit their applications by Jan 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses City or township governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Private institutions of higher education State governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public housing authorities/Indian housing authorities.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
Mechanisms, Models, Measurement, and Management in Pain Research (R01) is an NIH Funding Opportunity Announcement led by the National Institute of Nursing Research (NINR) that aims to expand and strengthen the overall pain research portfolio across multiple NIH Institutes and Centers. The announcement is designed to let researchers know what kinds of pain-related topics are priorities across NIH and to encourage a broad mix of studies that can move the field forward, including basic, clinical, and translational research. The central message is that pain remains a complex, highly individualized experience, and despite progress in areas like mapping pain pathways, major gaps persist in understanding why pain differs so much between people and why treatment is still often inadequate.
The FOA emphasizes that progress is needed at every level of analysis, ranging from molecular and cellular mechanisms to whole-person, behavioral, and social influences. In practical terms, that means applications can focus on mechanistic biology (for example, neural signaling, inflammation, genetics, or other physiological contributors), the development and refinement of pain models (including preclinical and clinical models that better reflect real-world pain conditions), improved measurement (such as better assessment tools, biomarkers, patient-reported outcomes, or approaches that capture the subjective and multidimensional nature of pain), and management strategies (including interventions, care delivery approaches, or methods to personalize treatment). The opportunity is intentionally broad to support innovation across the full spectrum of pain science and pain care.
A key expectation is that investigators approach pain as a multidisciplinary problem. The announcement strongly encourages interdisciplinary and multidisciplinary research teams, reflecting the reality that meaningful advances often require combining expertise across fields such as neuroscience, nursing, psychology, rehabilitation, pharmacology, epidemiology, social sciences, and health services research. It also explicitly encourages applications from underrepresented investigators, including minority, disabled, and women scientists, signaling an interest in strengthening diversity in the pain research workforce and in broadening perspectives brought to persistent research challenges.
Funding is provided through the NIH Research Project Grant (R01) mechanism, which typically supports well-developed, hypothesis-driven projects that can produce significant advances over a multi-year period. This R01 FOA runs in parallel with companion announcements of the same scientific scope that use other mechanisms: an R03 option (small grant) and an R21 option (exploratory/developmental). Applicants whose ideas are earlier-stage or smaller in scale are meant to consider those companion mechanisms, while applicants with more mature, comprehensive research plans are aligned with the R01 pathway.
Eligibility is broad and includes many types of organizations, such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses and other for-profit organizations (other than small businesses are also listed as eligible), state, county, city/township, and special district governments, independent school districts, public housing authorities/Indian housing authorities, Native American tribal governments and tribal organizations, and other entities as clarified in the full announcement. The FOA also states that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply. There is no cost sharing or matching requirement noted.
Administratively, the opportunity is listed as PA-07-282, categorized as a discretionary grant, and tied to multiple CFDA program areas that reflect the cross-cutting nature of pain research (including nursing research, neuroscience and neurological disorders, aging, child health and human development, arthritis and musculoskeletal and skin diseases, cancer treatment research, drug abuse and addiction research, oral diseases and disorders, deafness and communication disorders, and complementary and integrative health, among others). The announcement was originally posted January 8, 2007, with multiple receipt dates, and it remained open through early January 2010 per the listed current closing date, after which it was archived in February 2010. For the most authoritative details on scientific priorities, application requirements, and submission dates, the full FOA is hosted on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-07-282.html.
Frequently Asked Questions (FAQs)
1) What is the "Mechanisms, Models, Measurement, and Management in Pain Research (R01)" opportunity?
It is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) for Research Project Grants (R01) focused on advancing pain research. It is led by the National Institute of Nursing Research (NINR) and is intended to expand and strengthen pain research across multiple NIH Institutes and Centers.
2) What is the FOA number for this grant opportunity?
The FOA is listed as PA-07-282.
3) Which NIH Institute is leading this FOA?
The FOA is led by the National Institute of Nursing Research (NINR).
4) What is the overall goal of this FOA?
The goal is to encourage a broad mix of pain-related studies that can move the field forward, including basic, clinical, and translational research. It also communicates priority pain-research topics across NIH and highlights that major knowledge gaps remain despite progress in areas such as mapping pain pathways.
5) What is the main scientific premise emphasized by the announcement?
The FOA emphasizes that pain is complex and highly individualized, and that significant gaps remain in understanding why pain varies so much between individuals and why treatment is still often inadequate.
6) What kinds of research does the FOA encourage?
The FOA encourages basic, clinical, and translational research, and it is intentionally broad to support innovation across the full spectrum of pain science and pain care.
7) What research areas are explicitly highlighted in the FOA title and description?
The FOA highlights four broad areas: mechanisms, models, measurement, and management in pain research.
8) What does "mechanisms" research include under this FOA?
Mechanisms research can include work across levels of analysis, such as molecular and cellular mechanisms and physiological contributors. Examples mentioned include neural signaling, inflammation, genetics, and other biological contributors to pain.
9) What types of "models" are in scope?
The FOA supports the development and refinement of pain models, including both preclinical and clinical models, particularly those that better reflect real-world pain conditions.
10) What does the FOA mean by improved "measurement" in pain research?
Measurement topics can include better assessment tools, biomarkers, patient-reported outcomes, and approaches that capture the subjective and multidimensional nature of pain.
11) What does "management" cover in this FOA?
Management topics can include interventions, care delivery approaches, and methods to personalize treatment for pain.
12) Does the FOA emphasize any particular level of analysis?
Yes. The FOA emphasizes that progress is needed at every level of analysis, ranging from molecular and cellular mechanisms to whole-person, behavioral, and social influences.
13) Is interdisciplinary research encouraged?
Yes. The FOA strongly encourages interdisciplinary and multidisciplinary research teams, reflecting that advances in pain research often require combining expertise across multiple fields.
14) What disciplines are mentioned as relevant to interdisciplinary pain research teams?
Examples listed include neuroscience, nursing, psychology, rehabilitation, pharmacology, epidemiology, social sciences, and health services research.
15) Are applications from underrepresented investigators encouraged?
Yes. The FOA explicitly encourages applications from underrepresented investigators, including minority, disabled, and women scientists.
16) What grant mechanism is used for funding under this announcement?
Funding is provided through the NIH Research Project Grant (R01) mechanism.
17) What types of projects are generally aligned with the R01 mechanism in this FOA?
The R01 mechanism is described as typically supporting well-developed, hypothesis-driven projects that can produce significant advances over a multi-year period.
18) Are there related NIH opportunities with the same scientific scope but different mechanisms?
Yes. This R01 FOA runs in parallel with companion announcements that use other mechanisms: an R03 (small grant) option and an R21 (exploratory/developmental) option.
19) When should an applicant consider the companion R03 or R21 mechanisms instead of the R01?
According to the description provided, applicants with earlier-stage ideas or projects smaller in scale are meant to consider the R03 or R21 companion mechanisms, while mature and comprehensive research plans align with the R01 pathway.
20) What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); small businesses; other for-profit organizations; state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; Native American tribal governments and tribal organizations; and other entities as clarified in the full announcement.
21) Are foreign institutions eligible to apply?
Yes. The FOA states that foreign institutions may apply.
22) Are federal agencies eligible to apply?
Yes. The FOA states that eligible federal agencies may apply.
23) Are faith-based or community-based organizations eligible to apply?
Yes. The FOA states that faith-based or community-based organizations may apply.
24) Is cost sharing or matching required?
No cost sharing or matching requirement is noted in the information provided.
25) How is the grant categorized administratively?
It is categorized as a discretionary grant.
26) What program areas (CFDA) does this FOA relate to?
The FOA is tied to multiple CFDA program areas reflecting the cross-cutting nature of pain research, including nursing research, neuroscience and neurological disorders, aging, child health and human development, arthritis and musculoskeletal and skin diseases, cancer treatment research, drug abuse and addiction research, oral diseases and disorders, deafness and communication disorders, and complementary and integrative health, among others.
27) When was this FOA originally posted?
The announcement was originally posted on January 8, 2007.
28) Does the FOA have multiple application receipt dates?
Yes. The description indicates that it had multiple receipt dates.
29) Is this FOA still open?
No. Based on the information provided, it remained open through early January 2010, after which it was archived in February 2010.
30) Where can applicants find the authoritative FOA details?
The full FOA is hosted on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-07-282.html, which is identified as the best source for authoritative details on scientific priorities, application requirements, and submission dates.
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