Opportunity Information: Apply for PAR 11 052
Apply for PAR 11 052
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Mechanisms of Adverse Drug Reactions in Children (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on May 9, 2013 and posted on Dec 2, 2010.
- Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Public housing authorities/Indian housing authorities County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity called "Mechanisms of Adverse Drug Reactions in Children (R03)" (Funding Opportunity Number PAR-11-052) is a discretionary NIH funding announcement from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central purpose is to support small, focused research projects that investigate why children experience adverse drug reactions, specifically by studying the molecular, cellular, and genetic mechanisms that lead to these harmful or unexpected responses to medications. The emphasis is on understanding the underlying biology of adverse drug reactions in pediatric populations, which can include how a childs developing organs, immune system, metabolism, or genetic background influences drug safety and toxicity.
This FOA uses the NIH Small Research Grant (R03) mechanism, which is designed for projects that are modest in scope and can be completed relatively quickly with limited resources. The announcement highlights several project types that fit the R03 format: pilot and feasibility studies meant to generate early evidence and prepare for larger studies, secondary analyses of existing datasets, small self-contained research projects that answer a narrow and well-defined question, and efforts focused on developing research methodology or new research technology that can improve how adverse drug reactions are studied. In practical terms, this means applicants do not need to propose a large multi-site clinical trial to be competitive; instead, the FOA is well-suited to targeted mechanistic studies, proof-of-concept experiments, or analyses that clarify biological pathways and risk factors relevant to pediatric drug reactions.
The funding instrument is a grant, and the activity category is listed under Health, Income Security and Social Services, with CFDA number 93.865 (Child Health and Human Development Extramural Research). There is no cost sharing or matching requirement, so applicants are not required to provide institutional matching funds as a condition of receiving an award. The opportunity was originally posted on December 2, 2010, with key dates including an original closing date of May 7, 2013, a current closing date of May 7, 2014, and an archive date of June 7, 2014, indicating it is no longer active but remains useful as a reference for the kinds of projects NICHD was seeking under this mechanism.
Eligibility is broad and includes many types of U.S.-based organizations and institutions. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public housing authorities and Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (excluding institutions of higher education where specified); small businesses; and for-profit organizations other than small businesses. It also explicitly includes Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized tribal governments). The eligibility details further clarify that additional eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This wide eligibility reflects NIHs intent to attract a diverse set of applicants who can contribute mechanistic insights into pediatric adverse drug reactions from different scientific and community contexts.
Administratively, the sponsoring agency is the National Institutes of Health, with NICHD as the issuing institute. The full announcement was provided through the NIH grants guide (link included in the source), and technical help for accessing or linking to the announcement was routed to the NIH Office of Extramural Research (OER) webmaster via the email listed. Overall, this FOA is best understood as an NIH invitation for concise, mechanism-driven pediatric pharmacology and toxicology research that can be executed efficiently, often serving as a stepping stone toward larger R01-level studies once early mechanistic evidence is established.
Frequently Asked Questions (FAQs)
What is the "Mechanisms of Adverse Drug Reactions in Children (R03)" opportunity?
It is an NIH discretionary funding announcement titled "Mechanisms of Adverse Drug Reactions in Children (R03)" with Funding Opportunity Number PAR-11-052. It was issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main purpose of this funding opportunity?
The central purpose is to support small, focused research projects that investigate why children experience adverse drug reactions. The emphasis is on studying molecular, cellular, and genetic mechanisms that contribute to harmful or unexpected responses to medications in pediatric populations.
What types of adverse drug reaction questions is the FOA focused on?
The FOA focuses on the underlying biology of adverse drug reactions in children, including how developing organs, the immune system, metabolism, and genetic background may influence drug safety and toxicity.
What NIH grant mechanism does this FOA use?
This FOA uses the NIH Small Research Grant (R03) mechanism, which is intended for projects that are modest in scope and can be completed relatively quickly with limited resources.
What kinds of projects are a good fit for the R03 format under this announcement?
The announcement highlights several project types that fit the R03 format: pilot and feasibility studies to generate early evidence for larger studies, secondary analyses of existing datasets, small self-contained research projects addressing a narrow and well-defined question, and development of research methodology or new research technology to improve how adverse drug reactions are studied.
Does an application need to propose a large multi-site clinical trial to be competitive?
No. The FOA is positioned as well-suited to targeted mechanistic studies, proof-of-concept experiments, or analyses that clarify biological pathways and risk factors relevant to pediatric drug reactions, rather than large multi-site clinical trials.
What is the funding instrument for this opportunity?
The funding instrument is a grant.
What is the activity category and CFDA number associated with this opportunity?
The activity category is listed under Health, Income Security and Social Services, and the CFDA number is 93.865 (Child Health and Human Development Extramural Research).
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, so applicants are not required to provide institutional matching funds as a condition of receiving an award.
Is this funding opportunity currently active?
No. The dates provided indicate it is no longer active. It was originally posted on December 2, 2010, with an original closing date of May 7, 2013, a current closing date of May 7, 2014, and an archive date of June 7, 2014.
If it is archived, why is it still useful?
Even though it is no longer active, it can still be useful as a reference for the kinds of small, mechanism-driven pediatric adverse drug reaction projects NICHD was seeking under the R03 mechanism.
Which NIH institute issued this announcement?
The issuing institute is the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), within the National Institutes of Health (NIH).
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and institutions, including various government entities, higher education institutions, nonprofits, small businesses, and certain for-profit organizations.
Are state and local governments eligible?
Yes. Eligible applicants include state governments; county, city or township governments; special district governments; and independent school districts.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included as eligible applicants.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education as well as private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Eligibility includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (with the exclusions noted in the eligibility description where specified).
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are explicitly listed as eligible applicants.
Are Native American tribal governments and tribal organizations eligible?
Yes. Native American tribal governments (federally recognized) are eligible, and tribal organizations (including those other than federally recognized tribal governments) are also explicitly included.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility details.
Are minority-serving institutions specifically included?
Yes. The eligibility details explicitly mention Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other related entities.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included in the eligibility details.
Are regional organizations and federal agencies eligible?
Yes. Regional organizations and eligible federal agencies are listed among additional eligible applicants.
Where was the full announcement made available?
The full announcement was provided through the NIH grants guide (a link was included in the source information).
Where is technical help directed for accessing or linking to the announcement?
Technical help for accessing or linking to the announcement was routed to the NIH Office of Extramural Research (OER) webmaster via the email listed in the source.
How should this FOA be understood in terms of research trajectory?
It is best understood as an NIH invitation for concise, mechanism-driven pediatric pharmacology and toxicology research that can be executed efficiently, often serving as a stepping stone toward larger R01-level studies once early mechanistic evidence is established.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 11 052) also looked into and applied for these:
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| Studies in Neonatal Hypoglycemia (R03) Apply for PA 11 054 Funding Number: PA 11 054 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal Hypoglycemia (R01) Apply for PA 11 053 Funding Number: PA 11 053 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal Hypoglycemia (R21) Apply for PA 11 055 Funding Number: PA 11 055 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Mentored Patient Oriented Research Career Development Award in Muscular Dystrophy Research (K23) Apply for PA 11 076 Funding Number: PA 11 076 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00) Apply for PA 11 078 Funding Number: PA 11 078 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award in Muscular Dystrophy Research (K08) Apply for PA 11 077 Funding Number: PA 11 077 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Specialized Centers in Research in Pediatric Developmental Pharmacology Program (U54) Apply for RFA HD 10 026 Funding Number: RFA HD 10 026 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $500,000 |
| Research Infrastructure for Demographic and Behavioral Population Science (R24) Apply for RFA HD 10 020 Funding Number: RFA HD 10 020 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Rehabilitation Medicine Scientist Training (RMST) Program K12 Apply for RFA HD 11 081 Funding Number: RFA HD 11 081 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Indo US Program on Contraception and Reproductive Health Research (CRHR) R01 Apply for PAR 11 091 Funding Number: PAR 11 091 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Indo US Program on Maternal and Child Health and Human Development Research (MCHDR) (R03) Apply for PAR 11 092 Funding Number: PAR 11 092 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Scientific Meetings for Creating Collaborative Research Teams under the Indo US Program for Contraception and Reproductive Health Research (CRHR) R13 Apply for PAR 11 093 Funding Number: PAR 11 093 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Scientific Meetings for Creating Collaborative Research Teams under the Indo US Program for Maternal Child Health and Human Development Research (MCHDR) R13 Apply for PAR 11 094 Funding Number: PAR 11 094 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Intellectual and Developmental Disabilities Research Centers 2011 (P30) Apply for RFA HD 10 022 Funding Number: RFA HD 10 022 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Education Research in Sleep Health and Sleep Circadian Biology (R25) Apply for PAR 11 098 Funding Number: PAR 11 098 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Learning Disabilities Research Centers (P50) Apply for RFA HD 12 202 Funding Number: RFA HD 12 202 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,200,000 |
| Disclosure of HIV Status to Children in Low and Middle Income Country Settings (R21) Apply for RFA HD 12 205 Funding Number: RFA HD 12 205 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $250,000 |
| Disclosure of HIV Status to Children in Low and Middle Income Country Settings (R01) Apply for RFA HD 12 197 Funding Number: RFA HD 12 197 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $300,000 |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) Apply for PA 11 129 Funding Number: PA 11 129 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Model Systems for Fragile X Pre Mutation and Primary Ovarian Insufficiency (FX POI) (R21) Apply for PAR 11 137 Funding Number: PAR 11 137 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
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