Opportunity Information: Apply for PA 12 146
Apply for PA 12 146
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Mechanisms of Alcohol associated Cancers (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 29, 2012 and posted on Mar 29, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments City or township governments Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts County governments Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Mechanisms of Alcohol-associated Cancers (R01) funding opportunity (PA-12-146) is a National Institutes of Health (NIH) research grant announcement jointly issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Cancer Institute (NCI). It was created and posted on March 29, 2012, and it supported investigator-initiated R01 projects aimed at explaining, in clear biological and mechanistic terms, how alcohol consumption increases the risk of developing cancer. Alcohol is recognized as a human carcinogen by the International Agency for Research on Cancer (IARC), and this announcement was designed to push the field beyond population-level associations by encouraging studies that pin down the molecular, cellular, and tissue-level events that connect alcohol exposure to cancer initiation and progression.
A central focus of the announcement is on cancers with well-established links to alcohol use. The FOA highlights target sites that include the oral cavity, pharynx, esophagus, larynx, breast, liver, and colon. In practical terms, this means the program was looking for research that can explain why these tissues are vulnerable, what alcohol (and its metabolites) do to them over time, and how alcohol-related biological changes intersect with known cancer pathways. The underlying public health motivation is that better mechanistic understanding can translate into improved prevention strategies, more informed guidance about risk and safer consumption levels, and potentially new therapeutic approaches for alcohol-associated malignancies.
The announcement explicitly invites applications from researchers with a wide range of expertise, signaling that NIAAA and NCI were seeking multidisciplinary proposals rather than work confined to a single niche. Projects could logically span basic laboratory science (for example, studies of metabolic byproducts, DNA damage, oxidative stress, inflammation, epigenetic remodeling, immune modulation, microbiome-related effects, or altered hormonal signaling), translational research that links biomarkers to disease processes, and other mechanistic frameworks that clarify causality. The common thread is that the work should illuminate the mechanisms by which alcohol contributes to carcinogenesis, rather than simply reaffirming that a relationship exists.
Administratively, this was a discretionary funding opportunity using the NIH grant mechanism, specifically the R01 research project grant, which typically supports substantial, hypothesis-driven research programs. The activity category is listed under Education and Health, and the opportunity is associated with CFDA numbers 93.273 (Alcohol Research Programs) and 93.396 (Cancer Biology Research). The FOA did not require cost sharing or matching funds, which is typical for many NIH research grants and reduces barriers for applicants proposing resource-intensive biomedical studies.
Eligibility was broad and included many types of U.S. domestic organizations such as state and local governments, tribal governments and tribal organizations, public and private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), small businesses, and for-profit organizations other than small businesses. The eligibility language also calls out a wide variety of mission-driven and community-centered institutions, including Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, the FOA allowed non-U.S. entities (foreign institutions) to apply and permitted foreign components as defined by NIH policy, which reflects NIH’s interest in leveraging global expertise, unique cohorts, or specialized capabilities that may exist outside the United States.
In terms of timing, the original and current closing date for this particular announcement was September 7, 2015, and it was archived on October 8, 2015. While that means the specific FOA is no longer open, it remains a useful reference for understanding NIH priorities in alcohol-and-cancer mechanistic research and for shaping related proposals aligned with NIAAA and NCI interests. The full announcement was hosted through the NIH Grants Guide at the listed link, and the contact point provided for access or technical issues was the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the "Mechanisms of Alcohol-associated Cancers (R01)" funding opportunity (PA-12-146)?
PA-12-146 was a National Institutes of Health (NIH) research grant announcement for investigator-initiated R01 projects focused on explaining, in clear biological and mechanistic terms, how alcohol consumption increases the risk of developing cancer. It was jointly issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Cancer Institute (NCI).
Which NIH institutes were involved in this announcement?
This announcement was jointly issued by NIAAA and NCI, reflecting a shared interest in understanding how alcohol exposure contributes to cancer development and progression.
When was PA-12-146 created and posted?
The funding opportunity was created and posted on March 29, 2012.
What type of grant mechanism did this opportunity use?
The opportunity used the NIH R01 research project grant mechanism, which typically supports substantial, hypothesis-driven research programs.
What was the main research goal of the FOA?
The main goal was to move beyond population-level associations and support studies that identify the molecular, cellular, and tissue-level events linking alcohol exposure to cancer initiation and progression. The emphasis was on mechanistic clarity and biological causality.
How did the FOA frame alcohol in relation to cancer risk?
The FOA noted that alcohol is recognized as a human carcinogen by the International Agency for Research on Cancer (IARC) and aimed to support research explaining how alcohol contributes to carcinogenesis.
Which cancer sites were specifically highlighted as targets for research?
The FOA highlighted cancers with well-established links to alcohol use, including cancers of the oral cavity, pharynx, esophagus, larynx, breast, liver, and colon.
What kinds of scientific approaches were encouraged?
The FOA encouraged multidisciplinary, mechanistic work that could span basic laboratory science and translational research. Examples of relevant mechanistic areas mentioned include metabolic byproducts, DNA damage, oxidative stress, inflammation, epigenetic remodeling, immune modulation, microbiome-related effects, and altered hormonal signaling.
Did the FOA fund studies that only confirm an association between alcohol and cancer?
No. The common thread for supported projects was that they should illuminate mechanisms by which alcohol contributes to carcinogenesis, rather than simply reaffirming that a relationship exists at the population level.
What was the broader public health motivation behind this announcement?
The public health motivation was that improved mechanistic understanding could translate into better prevention strategies, more informed guidance about risk and safer consumption levels, and potentially new therapeutic approaches for alcohol-associated malignancies.
What was the activity category listed for this opportunity?
The activity category was listed under Education and Health.
Which CFDA numbers were associated with PA-12-146?
The opportunity was associated with CFDA 93.273 (Alcohol Research Programs) and 93.396 (Cancer Biology Research).
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching funds.
Who was eligible to apply within the United States?
Eligibility was broad and included many types of U.S. domestic organizations such as state and local governments, tribal governments and tribal organizations, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), small businesses, and for-profit organizations other than small businesses.
Did the eligibility criteria mention mission-driven or community-centered institutions?
Yes. The FOA explicitly called out a wide range of institutions, including Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions.
Could non-U.S. entities apply?
Yes. The FOA allowed non-U.S. entities (foreign institutions) to apply.
Were foreign components allowed under NIH policy?
Yes. The FOA permitted foreign components as defined by NIH policy.
What was the closing date for this announcement?
The original and current closing date for this particular announcement was September 7, 2015.
Is PA-12-146 still open for applications?
No. The FOA was archived on October 8, 2015, meaning the specific announcement is no longer open.
Why might this archived FOA still be useful?
Even though it is no longer open, it can still serve as a reference for understanding NIH priorities in alcohol-and-cancer mechanistic research and for shaping related proposals aligned with NIAAA and NCI interests.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide at the listed link in the original posting.
Who was listed as the contact for access or technical issues?
The contact point provided for access or technical issues was the NIH Office of Extramural Research (OER) webmaster.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 12 146) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mechanisms of Alcohol associated Cancers (R21) Apply for PA 12 147 Funding Number: PA 12 147 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Senior Scientist Research Award (K05) Apply for PA 12 048 Funding Number: PA 12 048 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| A Data Resource for Analyzing Blood and Marrow Transplants (Limited Competition U24) Apply for RFA CA 12 503 Funding Number: RFA CA 12 503 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Cancer Target Discovery and Development (CTDD) Network (U01) Apply for RFA CA 12 006 Funding Number: RFA CA 12 006 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| U.S. China Program for Biomedical Collaborative Research (R01) Apply for RFA AI 12 021 Funding Number: RFA AI 12 021 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| NLM Administrative Supplements for Informationist Services in NIH funded Research Projects (Admin Supp) Apply for PA 12 158 Funding Number: PA 12 158 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Senior Scientist Research Award (K05) Apply for PA 12 148 Funding Number: PA 12 148 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Basic Research on HIV Persistence (R21) Apply for PA 12 162 Funding Number: PA 12 162 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Basic Research on HIV Persistence (R01) Apply for PA 12 161 Funding Number: PA 12 161 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Clinical Sequencing Exploratory Research (U01) Apply for RFA HG 12 009 Funding Number: RFA HG 12 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,500,000 |
| Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34) Apply for PA 12 171 Funding Number: PA 12 171 Agency: National Institutes of Health Category: Education Health Funding Amount: $225,000 |
| Pre Application for the FY13 NIDA Avant Garde Award Program for HIV/AIDS Research (X02) Apply for PAR 12 164 Funding Number: PAR 12 164 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| FY13 NIDA Avant Garde Award Program for HIV/AIDS Research (DP1) Apply for RFA DA 13 002 Funding Number: RFA DA 13 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Identifying Health Outcomes Associated with Changes in Use of Illicit Drugs (R01) Apply for RFA DA 13 007 Funding Number: RFA DA 13 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Synthesis and Preclinical Evaluation of Medications to Treat Substance Use Disorders (SUDs) (R01) Apply for RFA DA 13 004 Funding Number: RFA DA 13 004 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovative Health Information Technology for Broad Adoption by Healthcare Systems and Consumers (SBIR) (R44) Apply for PA 12 196 Funding Number: PA 12 196 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Community Clinical Oncology Program Groups (U10) Apply for RFA CA 12 007 Funding Number: RFA CA 12 007 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Minority Based Community Clinical Oncology Program Groups (U10) Apply for RFA CA 12 008 Funding Number: RFA CA 12 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIMH Career Transition Award for Tenure Track and Tenured Intramural Investigators (K22) Apply for PAR 12 201 Funding Number: PAR 12 201 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Education Grants for Statistical and Computational Training in the Genetics of Addiction (R25) Apply for PAR 12 199 Funding Number: PAR 12 199 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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