Opportunity Information: Apply for PA 06 270
Apply for PA 06 270
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Mechanisms of Alcohol Associated Cancers (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Mar 24, 2006.
- Applicants must submit their applications by May 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education City or township governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply.
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Opportunity Summary:
The "Mechanisms of Alcohol Associated Cancers (R21)" funding opportunity (PA-06-270) is an NIH exploratory/developmental grant announcement sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in partnership with the National Cancer Institute (NCI) and the Office of Dietary Supplements (ODS). Its central goal is to support early-stage, innovative research that clarifies how long-term (chronic) alcohol consumption contributes to cancer development. The program is specifically focused on molecular and biochemical mechanisms, encouraging projects that connect alcohol exposure to the biological changes that initiate or promote tumors in multiple organs, including cancers of the oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast.
A key theme of the announcement is an integrative, state-of-the-art approach. Applicants are encouraged to use modern technologies and experimental strategies that can link pathways across different biological levels (for example, metabolism, DNA damage, signaling networks, immune effects, and tissue microenvironment). The FOA highlights several candidate mechanisms and mediators that researchers may investigate, such as acetaldehyde (a toxic alcohol metabolite), cytochrome P450 2E1 (CYP2E1) and associated oxidative stress, vascular endothelial growth factor (VEGF) and related angiogenesis processes, alcohol-related impairment of immune function, and disruptions in nutrient and methyl-donor metabolism. In particular, it calls attention to alcohol-induced impairment in pathways involving S-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A, reflecting strong interest in how altered metabolism and dietary supplement-related factors may influence carcinogenesis risk or progression in the context of alcohol exposure.
This announcement uses the NIH R21 mechanism, meaning it is designed for exploratory or developmental studies that may be higher-risk, conceptually bold, or aimed at generating preliminary data that could later support a larger R01. The R21 format typically fits projects that need a focused, short-term effort to test a new hypothesis, evaluate a new method, or establish feasibility for a broader research program. This FOA is run in parallel with a companion announcement of identical scientific scope that uses the traditional R01 mechanism (PA-06-269), giving applicants flexibility to choose the mechanism that best matches the maturity and scale of their proposed work.
Budget and project duration are intentionally flexible within set limits. Applicants may request up to two years of support, with a combined maximum of $275,000 in direct costs across the two-year period. The budget can be unevenly distributed between years (for example, $100,000 in year one and $175,000 in year two), as long as the overall cap is respected and the request is justified by the project’s needs. A typical expectation is that no more than $200,000 in direct costs should be requested in any single year. Because applications can vary widely in scientific scope and resource needs, NIH notes that award sizes and the number of awards will depend on available funds, application quality, project duration, and proposed costs.
Eligibility is broad, reflecting NIH’s intent to attract diverse scientific expertise. Domestic and foreign organizations may apply, and eligible applicants include public and private institutions such as universities, colleges, hospitals, laboratories, units of state and local government, eligible federal agencies, for-profit and non-profit organizations, and faith-based or community-based organizations. A wide variety of government entities (including tribal governments and organizations) and nonprofit categories are also eligible. On the investigator side, any individual with the skills, knowledge, and resources to lead the project may serve as the Project Director/Principal Investigator (PD/PI). NIH explicitly encourages applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities. The FOA also allows an applicant organization to submit more than one application, as long as each submission is scientifically distinct.
Administratively, this is a discretionary grant opportunity under NIH, with activity categories tied to alcohol research programs and cancer cause and prevention research (CFDA 93.273 and 93.393). There is no cost-sharing or matching requirement. The announcement originally operated with multiple receipt dates (rather than a single deadline), and it has since been archived, with the final listed closing date in May 2009 and an archive date in June 2009. For historical reference and full details, NIH provided a link to the full program announcement and offered NIH Office of Extramural Research (OER) webmaster contact support for access or linking issues.
Frequently Asked Questions (FAQs)
What is the "Mechanisms of Alcohol Associated Cancers (R21)" opportunity?
It is an NIH exploratory/developmental grant opportunity (Program Announcement PA-06-270) focused on early-stage, innovative research that clarifies how long-term (chronic) alcohol consumption contributes to cancer development.
Which NIH organizations sponsor or partner on this announcement?
The opportunity is sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in partnership with the National Cancer Institute (NCI) and the Office of Dietary Supplements (ODS).
What is the central scientific goal of this funding opportunity?
The central goal is to support exploratory or developmental studies that explain the molecular and biochemical mechanisms linking chronic alcohol exposure to biological changes that initiate or promote tumors.
What types of cancers or organ sites are in scope?
The announcement highlights multiple organ sites, including cancers of the oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast.
What kind of research approach does the FOA encourage?
It emphasizes integrative, state-of-the-art approaches that connect pathways across different biological levels, such as metabolism, DNA damage, signaling networks, immune effects, and the tissue microenvironment.
What mechanisms or mediators does the FOA specifically mention as examples?
Examples include acetaldehyde (a toxic alcohol metabolite), cytochrome P450 2E1 (CYP2E1) and oxidative stress, vascular endothelial growth factor (VEGF) and angiogenesis-related processes, alcohol-related impairment of immune function, and disruptions in nutrient and methyl-donor metabolism.
How does nutrient and methyl-donor metabolism fit into the FOA's interests?
The FOA calls attention to alcohol-induced impairment in pathways involving S-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A, reflecting interest in how altered metabolism and dietary supplement-related factors may influence carcinogenesis risk or progression under alcohol exposure.
What grant mechanism is used (R21), and what does that imply?
This announcement uses the NIH R21 mechanism, which is designed for exploratory/developmental projects that may be higher-risk, conceptually bold, or intended to generate preliminary data that could support a later, larger R01 application.
What kinds of projects are a typical fit for an R21 under this FOA?
Projects that need a focused, short-term effort to test a new hypothesis, evaluate a new method, or establish feasibility for a broader research program are described as a typical fit for the R21 format.
Is there a companion funding opportunity using a different mechanism?
Yes. The FOA notes a companion announcement with identical scientific scope that uses the traditional R01 mechanism (PA-06-269), allowing applicants to choose the mechanism that matches the maturity and scale of their work.
What is the maximum project period for this R21?
Applicants may request up to two years of support.
What is the maximum budget allowed under this announcement?
The combined maximum is $275,000 in direct costs across the two-year period.
Can the budget be allocated unevenly across the two years?
Yes. The FOA allows uneven distribution between years (for example, $100,000 in year one and $175,000 in year two), as long as the total direct costs do not exceed $275,000 and the request is well-justified.
Is there a per-year budget expectation mentioned?
Yes. A typical expectation stated is that no more than $200,000 in direct costs should be requested in any single year.
How are award sizes and the number of awards determined?
NIH indicates that award sizes and the number of awards depend on available funds, application quality, project duration, and proposed costs.
Who is eligible to apply as an organization?
Eligibility is broad and includes domestic and foreign organizations. Eligible applicants include public and private institutions such as universities, colleges, hospitals, laboratories, units of state and local government, eligible federal agencies, for-profit and non-profit organizations, and faith-based or community-based organizations. The FOA also includes a wide variety of government entities, including tribal governments and organizations, and other nonprofit categories.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA states that both domestic and foreign organizations may apply.
Who is eligible to serve as the Project Director/Principal Investigator (PD/PI)?
Any individual with the skills, knowledge, and resources necessary to carry out the proposed research may serve as the PD/PI.
Does the FOA encourage applications from underrepresented groups?
Yes. NIH explicitly encourages applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities.
Can an applicant organization submit more than one application?
Yes. The FOA allows an organization to submit more than one application, provided each application is scientifically distinct.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
What type of grant is this administratively?
It is a discretionary NIH grant opportunity, with activity categories tied to alcohol research programs and cancer cause and prevention research.
What CFDA numbers are associated with this announcement?
The FOA references CFDA 93.273 and 93.393.
Does this opportunity have a single deadline?
No. The announcement originally operated with multiple receipt dates rather than a single deadline.
Is this funding opportunity still active?
No. The announcement has been archived, with a final listed closing date in May 2009 and an archive date in June 2009.
Where can someone find the full archived program announcement or get help with access issues?
NIH provided a link to the full program announcement for historical reference and full details, and also listed NIH Office of Extramural Research (OER) webmaster contact support for access or linking issues.
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| Developmental Projects in Complementary Approaches to Cancer Care (R21) Apply for PA 06 400 Funding Number: PA 06 400 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Studies of Energy Balance and Cancer in Humans (R21) Apply for PA 06 405 Funding Number: PA 06 405 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Phased Innovation Research in Cancer Prognosis and Prediction (R21/R33) Apply for PA 06 434 Funding Number: PA 06 434 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Phase II Developmental Research in Cancer Prognosis and Prediction (R33) Apply for PA 06 435 Funding Number: PA 06 435 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Development of Frontal Cortex and Limbic System and their roles in Drug Abuse or Mental Health (R21) Apply for PA 06 445 Funding Number: PA 06 445 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Drug Abuse Dissertation Research Epidemiology, Prevention, Treatment, Services, and Women and Sex/Gender Differences (R36) Apply for PAR 06 476 Funding Number: PAR 06 476 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Behavioral and Integrative Treatment Development Program (R21) Apply for PA 06 487 Funding Number: PA 06 487 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Behavioral and Integrative Treatment Development Program (R03) Apply for PA 06 488 Funding Number: PA 06 488 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21) Apply for PA 06 496 Funding Number: PA 06 496 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03) Apply for PA 06 497 Funding Number: PA 06 497 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis(R21) Apply for PA 06 499 Funding Number: PA 06 499 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R03) Apply for PA 06 502 Funding Number: PA 06 502 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R21) Apply for PA 06 501 Funding Number: PA 06 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| National Cancer Institute (NCI) Cancer Education and Career Development Program (R25) Apply for PAR 06 511 Funding Number: PAR 06 511 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R21) Apply for PA 06 461 Funding Number: PA 06 461 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
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