Opportunity Information: Apply for PA 12 147
Apply for PA 12 147
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Mechanisms of Alcohol associated Cancers (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 29, 2012 and posted on Mar 29, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) For profit organizations other than small businesses Private institutions of higher education Public and State controlled institutions of higher education State governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement PA 12-147, titled "Mechanisms of Alcohol-associated Cancers (R21)," is a discretionary grant opportunity jointly issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Cancer Institute (NCI). It uses the NIH R21 mechanism, which is designed to support exploratory and developmental research projects that can open up new scientific directions, generate early proof-of-concept data, or test innovative ideas that may be too preliminary for larger, longer-term awards. In this case, the central purpose is to bring together researchers from many different fields to clarify how alcohol consumption biologically contributes to cancer development, with an emphasis on mechanistic studies rather than purely descriptive associations.
The scientific motivation for the program is grounded in the fact that alcohol has been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). The FOA highlights several cancer sites where alcohol-related risk is especially relevant, including cancers of the oral cavity, pharynx, esophagus, larynx, breast, liver, and colon. The announcement positions these cancers as key targets for investigation and encourages projects that can explain the underlying molecular and cellular events that link alcohol exposure to malignant transformation and tumor progression. The broader public health rationale is that mechanistic clarity can translate into improved prevention strategies, better therapeutic approaches, and more evidence-based guidance regarding safe or lower-risk levels of alcohol consumption.
At a practical level, the opportunity supports research that digs into the "how" of alcohol-associated carcinogenesis. That can include studying alcohol and its metabolites, their effects on DNA damage and repair, oxidative stress, inflammation, immune modulation, tissue microenvironment changes, epigenetic regulation, or interactions with other exposures and host factors. Because the FOA explicitly invites applicants with a broad range of expertise, it is meant to stimulate cross-disciplinary submissions that might integrate cancer biology, toxicology, molecular epidemiology, genomics, immunology, metabolism, microbiome research, and computational approaches, among others. The overall aim is to expand the field beyond established correlations by encouraging mechanistic hypotheses that can be tested experimentally and that could ultimately inform intervention points.
The award information provided indicates an award ceiling of $200,000, with no cost sharing or matching requirement. The opportunity is categorized under education and health, and it is associated with CFDA numbers 93.273 (Alcohol Research Programs) and 93.396 (Cancer Biology Research). The FOA was posted on March 29, 2012, with an original and current closing date listed as September 7, 2015, and an archive date of October 8, 2015, indicating that this specific announcement is no longer open for new applications but remains available as a reference for the program scope and NIH priorities at the time.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants span public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), state and local governments, special district governments, independent school districts, public housing authorities, and tribal governments and tribal organizations. The FOA also explicitly includes a range of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs), as well as faith-based or community-based organizations and regional organizations. Importantly, foreign institutions and non-U.S. entities are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed, reinforcing the intent to attract the strongest ideas globally.
In short, PA 12-147 is focused on catalyzing innovative, early-stage mechanistic research to explain why and how alcohol increases cancer risk across multiple organ sites. By prioritizing mechanistic understanding, the FOA frames this work as a foundation for tangible downstream impacts in cancer prevention, risk reduction guidance, and the identification of biological pathways that could be targeted for therapy or mitigation. For full details, the archived NIH program page is listed as http://grants.nih.gov/grants/guide/pa-files/PA-12-147.html, and NIH Office of Extramural Research (OER) web support contacts are provided for access or linking issues.
FAQs: NIH PA 12-147 - Mechanisms of Alcohol-associated Cancers (R21)
What is NIH FOA PA 12-147?
PA 12-147 is an NIH Funding Opportunity Announcement titled "Mechanisms of Alcohol-associated Cancers (R21)." It is a discretionary grant opportunity jointly issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Cancer Institute (NCI).
What is the main goal of this funding opportunity?
The central goal is to support mechanistic research that explains how alcohol consumption biologically contributes to cancer development. The emphasis is on understanding underlying molecular and cellular mechanisms, rather than only reporting descriptive associations between alcohol use and cancer risk.
What grant mechanism does this FOA use?
This FOA uses the NIH R21 mechanism, which supports exploratory and developmental research. R21 projects are intended to open new scientific directions, generate early proof-of-concept data, or test innovative ideas that may be too preliminary for larger or longer-term awards.
Which NIH Institutes are involved?
The opportunity is jointly issued by NIAAA and NCI, aligning alcohol research priorities with cancer biology research priorities.
Which cancers are highlighted as especially relevant to alcohol-related risk?
The FOA highlights alcohol-related risk for cancers of the oral cavity, pharynx, esophagus, larynx, breast, liver, and colon.
Why does NIH consider alcohol-related cancer mechanisms a priority area?
The FOA notes that alcohol has been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). NIH frames mechanistic understanding as a foundation for improved prevention strategies, better therapeutic approaches, and more evidence-based guidance on safer or lower-risk levels of alcohol consumption.
What kinds of research topics or mechanisms does the FOA encourage?
The FOA encourages research focused on the "how" of alcohol-associated carcinogenesis. Examples mentioned include studies of alcohol and its metabolites and their roles in DNA damage and repair, oxidative stress, inflammation, immune modulation, tissue microenvironment changes, epigenetic regulation, and interactions with other exposures and host factors.
Is this FOA limited to one scientific discipline?
No. The FOA explicitly seeks cross-disciplinary participation and encourages applicants from a wide range of fields to collaborate or bring new perspectives to mechanistic questions about alcohol and cancer.
What fields or approaches are mentioned as relevant for applicants?
The FOA mentions that projects may integrate expertise such as cancer biology, toxicology, molecular epidemiology, genomics, immunology, metabolism, microbiome research, and computational approaches, among others.
Does the FOA focus on mechanistic studies or observational associations?
The FOA emphasizes mechanistic studies rather than purely descriptive associations. The intent is to move beyond correlations by supporting experimentally testable mechanistic hypotheses.
What is the maximum award amount stated in the opportunity summary?
The award information provided lists an award ceiling of $200,000.
Is cost sharing or matching required?
No. The opportunity summary indicates there is no cost sharing or matching requirement.
How is this opportunity categorized?
The opportunity is categorized under education and health.
Which CFDA numbers are associated with this FOA?
The FOA is associated with CFDA 93.273 (Alcohol Research Programs) and 93.396 (Cancer Biology Research).
When was PA 12-147 posted, and what are the listed closing dates?
The FOA was posted on March 29, 2012. The original and current closing date is listed as September 7, 2015.
Is this funding opportunity still open?
No. The information provided indicates an archive date of October 8, 2015, and notes that the announcement is no longer open for new applications, but remains available as a reference for program scope and NIH priorities at the time.
Who is eligible to apply?
Eligibility is described as broad, covering many types of domestic and non-domestic organizations. Examples listed include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government and specialized public entities.
Are state, local, or tribal governments eligible?
Yes. The FOA includes state and local governments, special district governments, independent school districts, public housing authorities, and tribal governments and tribal organizations.
Are specific institution types (such as HBCUs or Hispanic-serving institutions) included in eligibility?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations, as well as regional organizations.
Can foreign (non-U.S.) organizations apply?
Yes. The FOA states that foreign institutions and non-U.S. entities are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA indicates non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed under NIH policy?
Yes. The FOA states that foreign components (as defined by NIH policy) are allowed.
What is the intended impact of funding mechanistic research in this area?
The FOA frames mechanistic clarity as a pathway to tangible downstream impacts, including improved cancer prevention strategies, risk reduction guidance, and identification of biological pathways that could be targeted for therapy or mitigation.
Where can the archived FOA be found?
The archived NIH program page is listed as http://grants.nih.gov/grants/guide/pa-files/PA-12-147.html.
Who is listed for help with access or linking issues?
The information provided notes that NIH Office of Extramural Research (OER) web support contacts are provided for access or linking issues.
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