Opportunity Information: Apply for PA 08 164
Apply for PA 08 164
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms of Alcohol Induced Tissue Injury (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.273 Alcohol Research Programs 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Apr 29, 2008.
- Applicants must submit their applications by May 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: City or township governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Special district governments Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Mechanisms of Alcohol Induced Tissue Injury (R01) funding opportunity (PA 08-164) is an NIH discretionary research grant announcement led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in collaboration with the National Heart, Lung, and Blood Institute (NHLBI). Its central goal is to support investigator-initiated biomedical research that explains how alcohol exposure causes tissue injury, with an explicit emphasis on studying these mechanisms in diverse populations and across the full human life span. In practical terms, the opportunity is meant to move beyond describing alcohol-related harm in broad terms and instead fund projects that pinpoint the biological pathways, molecular and cellular events, and physiological processes through which alcohol contributes to damage in organs and tissues, including but not limited to cardiovascular, pulmonary, hematologic, and other systems that align with the participating institutes missions.
The award mechanism is the NIH Research Project Grant (R01), which is the standard NIH vehicle for hypothesis-driven, investigator-led research projects. This structure typically supports a defined research plan with clear aims, rigorous methods, and strong preliminary rationale, allowing investigators to pursue mechanistic questions with substantial scientific depth. Because the FOA is framed as investigator-initiated, applicants are expected to propose their own specific research questions and experimental approaches within the overall theme of alcohol-induced tissue injury rather than responding to a narrowly prescribed set of topics.
Funding under this announcement is not guaranteed as a fixed set-aside. Instead, the NIH notes that awards will be made only if funds are available and if enough high-quality, scientifically meritorious applications are received. This means the number of awards is variable and depends on both NIH budget conditions and the strength of the submitted proposals. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal funds as a condition of receiving an award.
Eligibility is broad and includes many types of organizations that commonly apply for NIH research grants. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government such as state, county, city or township governments, special district governments, and independent school districts. The FOA also explicitly includes a wide range of mission-driven and community-anchored institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, tribal governments (both federally recognized and other tribal entities as specified), faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations. This inclusive eligibility list aligns with the program emphasis on diverse groups and life-span perspectives, encouraging applications that may be rooted in varied settings and populations.
From an administrative standpoint, the opportunity was posted on April 29, 2008, created on December 5, 2008, and had an original and final closing date of May 7, 2011, with an archive date of June 7, 2011. The associated CFDA numbers reflect the programmatic areas connected to the participating NIH components, including Alcohol Research Programs (93.273) as well as cardiovascular (93.837), lung (93.838), blood (93.839), and related research areas such as the National Center on Sleep Disorders Research (93.233), indicating the cross-cutting relevance of alcohol-related tissue injury to multiple organ systems and clinical domains.
Applicants looking for the full official announcement were directed to the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-08-164.html). For technical issues accessing the announcement, the point of contact listed is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, including help with electronic access or linking problems.
Frequently Asked Questions (FAQs): Mechanisms of Alcohol Induced Tissue Injury (R01) - PA 08-164
What is the "Mechanisms of Alcohol Induced Tissue Injury (R01)" opportunity?
This is an NIH discretionary research grant announcement (PA 08-164) supporting investigator-initiated biomedical research focused on understanding how alcohol exposure causes tissue injury.
Which NIH institute leads this funding opportunity?
The opportunity is led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in collaboration with the National Heart, Lung, and Blood Institute (NHLBI).
What is the main goal of this grant announcement?
The central goal is to fund research that explains the mechanisms by which alcohol exposure contributes to tissue injury. The emphasis is on identifying specific biological pathways, molecular and cellular events, and physiological processes rather than describing alcohol-related harm only in general terms.
What types of research questions are encouraged?
Projects are expected to be mechanistic and hypothesis-driven, focusing on how alcohol causes damage in organs and tissues. The announcement highlights relevance to multiple systems, including (but not limited to) cardiovascular, pulmonary, and hematologic systems, consistent with the missions of the participating institutes.
Does the FOA emphasize any particular populations or age groups?
Yes. The FOA explicitly emphasizes studying mechanisms of alcohol-induced tissue injury in diverse populations and across the full human life span.
What is the funding mechanism for this opportunity?
The award mechanism is the NIH Research Project Grant (R01), a standard NIH mechanism used for investigator-led, hypothesis-driven research projects with defined aims and rigorous methods.
Is this a targeted topic solicitation or investigator-initiated?
It is investigator-initiated. Applicants are expected to propose their own research questions and experimental approaches within the overall theme of alcohol-induced tissue injury, rather than responding to a narrowly prescribed list of topics.
Is funding guaranteed or set aside for this announcement?
No. The announcement states that awards are not guaranteed as a fixed set-aside. Awards depend on the availability of funds and the receipt of enough high-quality, scientifically meritorious applications.
Is the number of awards fixed?
No. The number of awards is variable and depends on NIH budget conditions and the strength and quality of the applications received.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement; applicants are not required to provide non-federal funds as a condition of receiving an award.
Who is eligible to apply?
Eligibility is broad. The FOA includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses), and government entities (such as state, county, city or township governments, special district governments, and independent school districts).
Are community-based or faith-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
Are minority-serving institutions specifically included?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and other community-anchored or mission-driven entities.
Are tribal governments eligible to apply?
Yes. The FOA includes tribal governments (including federally recognized tribal governments and other tribal entities as specified in the eligibility list).
Can non-U.S. (foreign) organizations apply?
Yes. The FOA explicitly includes non-U.S. (foreign) organizations as eligible applicants.
Are U.S. territories or possessions included in eligibility?
Yes. The FOA includes U.S. territories or possessions among eligible entities.
When was this opportunity posted and when did it close?
The opportunity was posted on April 29, 2008, created on December 5, 2008, and had an original and final closing date of May 7, 2011. The archive date is June 7, 2011.
What does it mean that the opportunity is archived?
Based on the provided dates, the FOA reached its final closing date on May 7, 2011 and was archived on June 7, 2011.
What CFDA numbers are associated with this announcement?
The FOA references multiple CFDA numbers reflecting the participating NIH components and relevant research areas: Alcohol Research Programs (93.273), cardiovascular research (93.837), lung research (93.838), blood research (93.839), and the National Center on Sleep Disorders Research (93.233).
Where can applicants find the official NIH announcement?
The official announcement is available via the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-08-164.html
Who should be contacted for technical issues accessing the announcement link?
For technical issues related to electronic access or linking problems, the point of contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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