Opportunity Information: Apply for PAR 14 051
Apply for PAR 14 051
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanisms of Behavior Change in the Treatment of Alcohol Use Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 23, 2013 and posted on Dec 23, 2013.
- Applicants must submit their applications by Mar 17, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $498,500.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education City or township governments Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Mechanisms of Behavior Change in the Treatment of Alcohol Use Disorders (R01)" (Funding Opportunity Number PAR-14-051) supported research aimed at understanding how and why behavioral treatments for alcohol use disorders (AUD) actually work. Rather than focusing only on whether a therapy reduces drinking, this FOA emphasized digging into the underlying processes that drive improvement during treatment. The core idea was to move beyond outcome-only studies and fund projects that can identify the active ingredients within empirically supported behavioral interventions and connect those ingredients to measurable mechanisms of change. By doing that, the field can refine existing therapies, improve matching of patients to treatments, and develop more targeted, efficient interventions that reliably produce better AUD outcomes.
A central priority of the announcement was the study of mechanisms that facilitate behavior change within established, evidence-based behavioral treatments for AUD. Applicants were encouraged to test hypotheses about what components of treatment (for example, specific counseling strategies, skills training elements, motivational components, or therapeutic techniques) produce change, and through what pathway those changes occur. The FOA highlighted the need to identify mediators that sit between the treatment component and the clinical outcome, such as reductions in craving, improvements in coping skills, changes in reward valuation, stronger self-regulation, increased motivation, or shifts in alcohol-related expectancies. In practical terms, NIH was signaling that it wanted well-designed research capable of demonstrating not just correlation but plausible causal chains linking treatment delivery to changes in intermediate targets and, ultimately, to drinking outcomes.
Another major emphasis was translational research. The FOA explicitly encouraged work that bridges behavioral clinical research with neurobiological and cognitive science by identifying neurobiological or cognitive processes that could function as mechanisms of therapeutic change. This meant applicants could propose studies that incorporate cognitive tasks, neuroimaging, psychophysiology, behavioral economics measures, or other approaches that shed light on how treatment affects brain systems and cognitive functions implicated in addiction and recovery. The purpose of this translational angle was to strengthen the scientific explanation for behavior change in AUD treatment and to support the development of more mechanism-informed interventions, potentially enabling treatment approaches that are more precise, personalized, and scalable.
This opportunity used the NIH R01 research project grant mechanism, indicating support for mature, hypothesis-driven projects with a strong scientific premise and adequate preliminary rationale. The activity category was Health, and the CFDA number associated with it was 93.273 (Alcohol Research Programs). The announcement did not require cost sharing or matching. The listed award ceiling in the provided data was $498,500, which typically signals an upper limit in the opportunity details as presented in the source record, although actual NIH award amounts can vary depending on the approved budget, project scope, and institute policies.
Eligibility for PAR-14-051 was broad and included many U.S.-based organization types across academia, government, nonprofit, and industry. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exception categories), small businesses, for-profit organizations other than small businesses, and multiple levels of government such as state, county, city/township, special district governments, and independent school districts. It also included public housing authorities/Indian housing authorities and Native American tribal governments (federally recognized) as well as tribal organizations (other than federally recognized tribal governments). The FOA also identified additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government. At the same time, the announcement clearly excluded non-U.S. entities: foreign institutions were not eligible to apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed, reinforcing that the supported research effort had to be conducted within eligible domestic organizational structures.
Key administrative dates in the source data show the FOA was posted and created on December 23, 2013, with an original closing date and current closing date of March 17, 2016. The archive date was April 17, 2016, indicating the opportunity is no longer active. The sponsoring agency was the National Institutes of Health. For applicants or readers needing the full announcement text, the additional information link was provided as http://grants.nih.gov/grants/guide/pa-files/PAR-14-051.html, and the contact listed for access or linking issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PAR-14-051 was designed to accelerate progress in AUD treatment science by funding rigorous research that isolates what parts of behavioral interventions drive change and clarifies the cognitive and neurobiological processes through which those treatment elements improve alcohol-related outcomes. The larger impact NIH appeared to be aiming for was a more mechanistic, experimentally grounded foundation for behavioral AUD treatments, making it easier to optimize therapies, improve durability of effects, and translate basic behavioral and brain science into real-world clinical benefit.
Frequently Asked Questions (FAQs)
What is PAR-14-051?
PAR-14-051 is an NIH Funding Opportunity Announcement (FOA) titled "Mechanisms of Behavior Change in the Treatment of Alcohol Use Disorders (R01)." It supported research focused on understanding how and why evidence-based behavioral treatments for alcohol use disorders (AUD) produce improvement, not just whether they reduce drinking.
What is the main purpose of this NIH opportunity?
The purpose was to move beyond outcome-only studies and fund projects that identify the active ingredients within established behavioral interventions for AUD and connect those ingredients to measurable mechanisms of change. The goal was to build a clearer, more experimentally grounded explanation for behavior change during treatment.
What does NIH mean by "mechanisms of behavior change" in this FOA?
In this FOA, mechanisms of behavior change refer to intermediate processes that plausibly explain how specific elements of a behavioral treatment lead to improved clinical outcomes. The announcement emphasized identifying and testing mediators that sit between the treatment component (what is delivered) and the clinical outcome (drinking-related outcomes).
How is this different from a typical treatment outcome study?
Rather than focusing primarily on whether a therapy works (for example, whether drinking decreases), this FOA emphasized studies that can explain why it works by testing specific hypotheses about treatment components and the pathways through which those components drive change.
What kinds of behavioral AUD treatments were the focus?
The focus was on established, evidence-based behavioral treatments for AUD. The FOA emphasized investigating mechanisms that facilitate behavior change within empirically supported interventions rather than treating the therapy as a single "black box."
What types of treatment components could be studied as "active ingredients"?
The FOA described examples of treatment components such as specific counseling strategies, skills training elements, motivational components, or other therapeutic techniques. Applicants were encouraged to test hypotheses about which components produce change and through what pathway.
What are examples of mechanisms or mediators that NIH highlighted?
The FOA provided examples of mediators that could link treatment to outcomes, including reductions in craving, improvements in coping skills, changes in reward valuation, stronger self-regulation, increased motivation, or shifts in alcohol-related expectancies.
What did NIH emphasize about study design and evidence for mechanisms?
NIH emphasized the need for well-designed research that can demonstrate more than correlation, aiming for plausible causal chains linking treatment delivery to changes in intermediate targets (mechanisms/mediators) and, ultimately, to drinking outcomes.
What does the "translational" emphasis mean in this FOA?
The translational emphasis encouraged research that bridges behavioral clinical research with neurobiological and cognitive science. Applicants could incorporate measures and methods that help explain how treatment affects brain systems and cognitive functions relevant to addiction and recovery.
What kinds of translational methods or measures were encouraged?
The FOA mentioned approaches such as cognitive tasks, neuroimaging, psychophysiology, and behavioral economics measures, as well as other methods that could illuminate neurobiological or cognitive processes functioning as mechanisms of therapeutic change.
What grant mechanism did this opportunity use?
This FOA used the NIH R01 research project grant mechanism, which generally indicates support for mature, hypothesis-driven projects with a strong scientific premise and adequate preliminary rationale.
What is the CFDA number and program area for this opportunity?
The CFDA number listed was 93.273, associated with Alcohol Research Programs. The activity category was Health.
Did PAR-14-051 require cost sharing or matching?
No. The announcement data indicated that cost sharing or matching was not required.
What was the listed award ceiling?
The listed award ceiling in the provided opportunity data was $498,500. The description also noted that actual NIH award amounts can vary depending on the approved budget, project scope, and institute policies.
Who was eligible to apply?
Eligibility was broad across many U.S.-based organization types, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with noted exception categories), small businesses, and for-profit organizations other than small businesses. Multiple levels of government were also eligible (state, county, city/township, special district governments, independent school districts), as were public housing authorities/Indian housing authorities.
Were tribal entities eligible applicants?
Yes. Eligible applicants included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), as described in the opportunity information.
Were certain institution types specifically called out as eligible?
Yes. The FOA listed categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government.
Are foreign institutions or non-U.S. entities eligible?
No. The FOA explicitly excluded non-U.S. entities: foreign institutions were not eligible to apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed.
Is this funding opportunity still open?
No. The opportunity is archived. The source data listed an original and current closing date of March 17, 2016, and an archive date of April 17, 2016.
When was the FOA posted?
The source data indicated the FOA was posted/created on December 23, 2013.
Which federal agency sponsored this FOA?
The sponsoring agency was the National Institutes of Health (NIH).
Where can the full FOA text be found?
The additional information link provided was: http://grants.nih.gov/grants/guide/pa-files/PAR-14-051.html
Who is the contact for access or linking issues related to the FOA page?
The contact listed for access or linking issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What broader impact was NIH aiming for with PAR-14-051?
The FOA was designed to accelerate progress in AUD treatment science by isolating what parts of behavioral interventions drive change and clarifying the cognitive and neurobiological processes through which those elements improve alcohol-related outcomes. The intended impact was to support refinement of existing therapies, improve matching of patients to treatments, and enable more targeted, efficient, and potentially more personalized and scalable interventions.
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