Opportunity Information: Apply for PA 08 099
Apply for PA 08 099
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Mechanisms of Functional Recovery After Stroke (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Mar 5, 2008.
- Applicants must submit their applications by May 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Independent school districts County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity "Mechanisms of Functional Recovery After Stroke (R01)" (FOA number PA-08-099) supports full Research Project Grant (R01) applications aimed at understanding how the brain repairs itself and reorganizes after a stroke, and how those biological processes can be influenced to improve real-world recovery. It is sponsored by several NIH institutes because stroke-related disability affects multiple domains of health and function: the National Institute of Neurological Disorders and Stroke (NINDS) as the lead for stroke and nervous system injury, along with NICHD (development and rehabilitation across the lifespan), NIA (aging-related stroke burden and recovery), and NIDCD (communication disorders that often follow stroke). The overarching goal is to move beyond purely empirical rehabilitation routines by building a stronger mechanistic science base that can guide new, more effective interventions to restore function.
The opportunity is grounded in a major clinical reality: although stroke is among the leading causes of death, it is even more significant as the leading cause of long-term disability in the United States. Over the decade leading up to this announcement, research priorities heavily emphasized acute stroke treatment, such as restoring blood flow (reperfusion) and limiting immediate neuronal injury. As acute care improved and more people survived stroke, the unmet need shifted toward functional restoration and long-term rehabilitation. The FOA highlights that, despite rehabilitation being a routine part of clinical stroke care, many rehabilitation practices remain largely behavioral and experience-driven, with limited support from large randomized controlled trials and an incomplete understanding of the underlying neural repair and plasticity mechanisms that would explain why certain patients recover while others do not.
Projects responsive to this FOA would typically focus on basic and translational research that clarifies the brain mechanisms of repair, plasticity, and reorganization after stroke, and the biological and environmental factors that shape those mechanisms. This can include studying how neural circuits adapt after injury, how the brain forms new connections or strengthens existing ones, how spared brain regions compensate for lost function, and how these changes relate to measurable behavioral improvements. The FOA also encourages research on approaches that might enhance or optimize reparative processes, with the long-term intent of informing and improving rehabilitation strategies. In practical terms, that means investigators can propose mechanistic studies as well as studies that test methods intended to boost recovery, provided the work advances understanding of how recovery happens and how it can be improved.
Administratively, this is a discretionary NIH grant using the R01 mechanism, categorized under Health, Income Security, and Social Services. The CFDA program areas listed reflect the participating institutes and include neurosciences and neurological disorders, aging research, child health and human development research, and deafness and communication disorders research. There is no cost sharing or matching requirement. The opportunity was posted March 5, 2008, and ultimately closed May 7, 2011 (with an archive date of June 7, 2011), which means it is no longer active, but it remains a useful reference for the types of stroke recovery questions NIH has prioritized and the scope of work considered responsive.
Eligibility is broad and includes many kinds of domestic U.S. organizations and governments, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), independent school districts, and various local, state, tribal, and special district governmental entities. The announcement also specifies that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based and community-based organizations are eligible as well. For applicants and researchers, the takeaway is that NIH intended this program to be accessible to a wide range of capable institutions, so long as the proposed science directly addresses mechanisms of post-stroke neural repair and plasticity and connects that biology to functional outcomes and potential rehabilitation advances.
The full archived announcement was originally available through the NIH Grants Guide (PA-08-099), and the listed contact for access or linking issues was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the NIH funding opportunity "Mechanisms of Functional Recovery After Stroke (R01)" (PA-08-099)?
This NIH funding opportunity supported Research Project Grant (R01) applications focused on understanding how the brain repairs itself and reorganizes after a stroke, and how those biological processes can be influenced to improve real-world functional recovery.
What type of grant mechanism does this opportunity use?
It uses the NIH Research Project Grant (R01) mechanism.
What is the main goal of this FOA?
The overarching goal is to move beyond mostly empirical, experience-driven rehabilitation routines by building a stronger mechanistic science base. The intent is to generate knowledge about neural repair and plasticity that can guide the development of more effective interventions to restore function after stroke.
Why did NIH emphasize functional recovery and rehabilitation in this announcement?
The FOA is grounded in a clinical reality: stroke is a leading cause of long-term disability in the United States. In the decade leading up to the announcement, research priorities heavily emphasized acute stroke treatment (for example, restoring blood flow and limiting immediate injury). As acute care improved and more people survived stroke, the unmet need shifted toward functional restoration and long-term rehabilitation.
Which NIH institutes sponsored or participated in this opportunity?
Multiple NIH institutes participated because stroke-related disability affects multiple domains of health and function. NINDS served as the lead (stroke and nervous system injury), with NICHD (development and rehabilitation across the lifespan), NIA (aging-related stroke burden and recovery), and NIDCD (communication disorders that often follow stroke).
What kinds of research projects were considered responsive to this FOA?
Projects were typically basic and translational studies aimed at clarifying mechanisms of post-stroke repair, plasticity, and reorganization, along with the biological and environmental factors that shape those mechanisms. The FOA also encouraged research on approaches that might enhance or optimize reparative processes, especially when the work advances understanding of how recovery happens and how it can be improved.
Does this FOA focus only on rehabilitation practices or does it include biological mechanisms?
It explicitly emphasizes biological mechanisms. The FOA notes that many rehabilitation practices have been largely behavioral and experience-driven, with limited support from large randomized controlled trials and incomplete understanding of neural repair and plasticity mechanisms. The program was designed to strengthen the mechanistic foundation underlying recovery and rehabilitation.
What specific scientific themes or questions does the FOA highlight?
Examples of responsive themes include how neural circuits adapt after injury, how the brain forms new connections or strengthens existing ones, how spared brain regions compensate for lost function, and how these biological changes relate to measurable behavioral improvements.
Does the FOA allow studies that test methods intended to boost recovery?
Yes. Investigators could propose studies that test methods intended to boost recovery, as long as the work advances understanding of the mechanisms of recovery and how those mechanisms can be influenced to improve outcomes.
How does this FOA define "real-world" recovery outcomes?
The announcement frames recovery in terms of functional outcomes and measurable behavioral improvements, tying biological repair and reorganization processes to improvements that matter in practical function after stroke.
What category does this funding opportunity fall under administratively?
It is described as a discretionary NIH grant categorized under Health, Income Security, and Social Services.
Are there listed CFDA program areas associated with the participating institutes?
Yes. The CFDA program areas reflect the participating institutes and include neurosciences and neurological disorders, aging research, child health and human development research, and deafness and communication disorders research.
Is there a cost sharing or matching requirement?
No. The FOA states there is no cost sharing or matching requirement.
When was this opportunity posted, and is it still active?
It was posted March 5, 2008. It ultimately closed May 7, 2011, with an archive date of June 7, 2011. This means it is no longer active.
If the FOA is closed, why might it still be useful?
Even though it is no longer active, it remains a useful reference for the types of stroke recovery questions NIH has prioritized and for understanding the scope of work considered responsive in this area.
Who was eligible to apply?
Eligibility was broad and included many kinds of domestic U.S. organizations and governments: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), independent school districts, and various local, state, tribal, and special district governmental entities.
Were foreign institutions eligible to apply?
Yes. The announcement specifies that foreign institutions were eligible to apply.
Could federal agencies apply?
Yes. The announcement indicates that eligible federal agencies could apply.
Are faith-based and community-based organizations eligible?
Yes. The FOA states that faith-based and community-based organizations are eligible.
What is the key eligibility takeaway for applicants?
NIH intended the program to be accessible to a wide range of capable institutions, provided the proposed science directly addresses mechanisms of post-stroke neural repair and plasticity and connects that biology to functional outcomes and potential rehabilitation advances.
Where was the full announcement originally available?
The full archived announcement was originally available through the NIH Grants Guide under FOA number PA-08-099.
Who was listed as a contact for access or linking issues with the archived announcement?
The listed contact for access or linking issues was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Browse more opportunities from the same category: Health Income Security and Social Services
Next opportunity: Mechanisms of Functional Recovery After Stroke (R21)
Previous opportunity: Functional Links between the Immune System, Brain Function and Behavior (R21)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 08 099
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 099) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mechanisms of Functional Recovery After Stroke (R21) Apply for PA 08 100 Funding Number: PA 08 100 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Leiomyomata Uteri Basic Science, Translational and Clinical Research (R01) Apply for PAR 08 102 Funding Number: PAR 08 102 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Adverse Outcomes of Assisted Reproductive Technologies (R01) Apply for PA 08 104 Funding Number: PA 08 104 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Investigations on Primary Immunodeficiency Diseases (R01) Apply for PAR 08 206 Funding Number: PAR 08 206 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Biosocial Approaches to Infertility Research (R21) Apply for PA 09 032 Funding Number: PA 09 032 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Womens Reproductive Health Research (WRHR) Career Development Program (K12) Apply for RFA HD 08 014 Funding Number: RFA HD 08 014 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $440,000 |
| Population Research Infrastructure Program Short term Support for Rising Programs (R24) Apply for PAR 07 401 Funding Number: PAR 07 401 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Collaborative Pediatric Critical Care Research Network (U10) Apply for RFA HD 08 025 Funding Number: RFA HD 08 025 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Postdoctoral Research Training for Obstetricians and Gynecologists (T32) Apply for PAR 09 049 Funding Number: PAR 09 049 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Obstetric Pharmacology Research Units (U10) Apply for RFA HD 09 002 Funding Number: RFA HD 09 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $650,000 |
| Advanced Neural Prosthetics Research and Development (U01) Apply for PA 09 063 Funding Number: PA 09 063 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Enhancing Developmental Biology Research at Undergraduate Institutions Academic Research Enhancement Award (R15) Apply for PAR 09 084 Funding Number: PAR 09 084 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders SBIR (R43/R44) Apply for PA 07 396 Funding Number: PA 07 396 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Academic Community Partnership Conference Series (U13) Apply for PAR 09 092 Funding Number: PAR 09 092 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $30,000 |
| Childhood Obesity Prevention and Treatment Research Consortium (U01) Apply for RFA HL 10 004 Funding Number: RFA HL 10 004 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Childhood Obesity Prevention and Treatment Research Coordinating Unit (U01) Apply for RFA HL 10 005 Funding Number: RFA HL 10 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Outcomes Research in Orthotics and Prosthetics (R01) Apply for RFA HD 09 007 Funding Number: RFA HD 09 007 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $350,000 |
| Translational Research in Pediatric and Obstetric Pharmacology (R03) Apply for PAR 09 154 Funding Number: PAR 09 154 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Translational Research in Pediatric and Obstetric Pharmacology (R01) Apply for PAR 09 155 Funding Number: PAR 09 155 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Translational Research in Pediatric and Obstetric Pharmacology (R21) Apply for PAR 09 156 Funding Number: PAR 09 156 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $275,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 08 099", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.