Opportunity Information: Apply for PA 15 026
Apply for PA 15 026
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Mechanistic Studies of Pain and Alcohol Dependence (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Oct 31, 2014 and posted on Oct 31, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses State governments City or township governments Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Mechanistic Studies of Pain and Alcohol Dependence (R01) (Funding Opportunity Number PA-15-026) is a National Institutes of Health discretionary grant opportunity that supports R01-scale research focused on the biological and behavioral mechanisms linking pain and alcohol use, particularly excessive drinking and alcohol dependence. The central premise is that chronic pain and alcohol dependence frequently co-occur, and the direction of that relationship can run both ways: in some individuals, heavy alcohol use predates and may contribute to later chronic pain, while in others, alcohol dependence can develop after chronic pain begins, potentially as a maladaptive coping strategy. The FOA highlights that pain signaling pathways and the reinforcing (rewarding) effects of alcohol involve overlapping neural circuitry, which raises the possibility that persistent pain states can shift alcohol use patterns in ways that increase risk for dependence or addiction. At the same time, the announcement emphasizes the reverse pathway as well: long-term alcohol intoxication and dependence can produce pain symptoms and may worsen pain from other causes, creating a self-reinforcing cycle where pain and alcohol use escalate each other.
The objective of the FOA is explicitly mechanistic. NIH is seeking studies that move beyond simple correlation and instead identify how and why these conditions interact. Applicants are encouraged to investigate genetic factors that influence both pain responses and propensity for excessive alcohol consumption, pharmacological mechanisms that may alter pain sensitivity or alcohol reinforcement, and learning-related mechanisms (for example, conditioning, negative reinforcement, stress-related learning, or other behavioral processes) that could explain how pain experiences shape drinking behavior or how alcohol exposure reshapes pain processing over time. In practical terms, this could include work that disentangles shared brain substrates, identifies molecular targets or signaling pathways implicated in both phenomena, or clarifies how chronic pain changes motivation, reward valuation, and relapse vulnerability in alcohol use disorder models. The overall thrust is to generate knowledge that can inform better prevention and treatment strategies for patients affected by both chronic pain and alcohol misuse by pinpointing actionable mechanisms rather than treating the overlap as incidental.
Administratively, this FOA uses the NIH R01 grant mechanism and falls within health and education-related research activities, with CFDA listings 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). Cost sharing or matching is not required. The opportunity was posted on October 31, 2014, with an original and current closing date of January 7, 2018, and an archive date of February 7, 2018, indicating it is no longer open for new submissions under that specific announcement.
Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, public/state-controlled universities, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special districts, independent school districts), as well as public housing authorities and Indian housing authorities. The FOA also lists several specialized categories such as Historically Black Colleges and Universities, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions. Importantly, foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components as defined by NIH policy are allowed. The full announcement was available through the NIH Grants Guide (link provided in the source), and NIH’s Office of Extramural Research webmaster contact information is provided for access or technical issues with the posting.
Frequently Asked Questions (FAQs)
What is the grant opportunity?
Mechanistic Studies of Pain and Alcohol Dependence (R01) (Funding Opportunity Number PA-15-026) is a National Institutes of Health (NIH) discretionary grant opportunity supporting R01-scale research on the biological and behavioral mechanisms that link pain and alcohol use, with an emphasis on excessive drinking and alcohol dependence.
What is the main purpose of this FOA?
The objective is explicitly mechanistic. NIH is looking for studies that move beyond correlation and instead identify how and why chronic pain and alcohol dependence interact, including the pathways that may drive co-occurrence and escalation over time.
What relationship between pain and alcohol dependence does the FOA emphasize?
The FOA highlights that chronic pain and alcohol dependence frequently co-occur and that the direction of the relationship can run both ways. In some individuals, heavy alcohol use may come first and contribute to later chronic pain. In others, alcohol dependence may develop after chronic pain begins, potentially as a maladaptive coping strategy.
Does the FOA discuss a feedback loop between pain and alcohol use?
Yes. It describes a self-reinforcing cycle where persistent pain can shift alcohol use patterns in ways that increase dependence risk, and long-term alcohol intoxication/dependence can produce pain symptoms or worsen other pain conditions, potentially escalating both pain and alcohol use.
Why does NIH believe pain and alcohol reinforcement are connected?
The FOA notes that pain signaling pathways and the reinforcing (rewarding) effects of alcohol involve overlapping neural circuitry. This overlap raises the possibility that persistent pain states can alter drinking behavior and increase vulnerability to dependence or addiction.
What kinds of studies are encouraged under this opportunity?
Applicants are encouraged to propose mechanistic studies that clarify shared or interacting processes, such as disentangling shared brain substrates, identifying molecular targets or signaling pathways implicated in both pain and alcohol dependence, and examining how chronic pain changes motivation, reward valuation, and relapse vulnerability in alcohol use disorder models.
Are genetic mechanisms within scope?
Yes. The FOA specifically encourages investigation of genetic factors that influence both pain responses and propensity for excessive alcohol consumption.
Are pharmacological mechanisms within scope?
Yes. The FOA encourages research into pharmacological mechanisms that may alter pain sensitivity or alcohol reinforcement.
Are learning and behavioral mechanisms within scope?
Yes. The FOA calls out learning-related mechanisms such as conditioning, negative reinforcement, stress-related learning, and other behavioral processes that could explain how pain experiences shape drinking behavior or how alcohol exposure reshapes pain processing over time.
What does “mechanistic†mean in the context of this FOA?
In this FOA, mechanistic means identifying causal or explanatory pathways that describe how and why pain and alcohol dependence influence each other (for example, specific neural circuitry, molecular signaling pathways, genetic influences, pharmacological effects, or learning processes), rather than only showing that the conditions are associated.
What is the intended impact of the research supported by this FOA?
The thrust is to generate knowledge that can inform better prevention and treatment strategies for people affected by both chronic pain and alcohol misuse by pinpointing actionable mechanisms rather than treating the overlap as incidental.
What funding mechanism does this FOA use?
This opportunity uses the NIH R01 grant mechanism.
What are the CFDA program listings associated with this opportunity?
The FOA references CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs).
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
When was this FOA posted, and what were the key dates?
The opportunity was posted on October 31, 2014. The original and current closing date is January 7, 2018, and the archive date is February 7, 2018.
Is this funding opportunity still open?
No. Based on the closing date (January 7, 2018) and archive date (February 7, 2018), this specific announcement is no longer open for new submissions.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and non-domestic organizations, including public and private institutions of higher education, public/state-controlled universities, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special districts, independent school districts), as well as public housing authorities and Indian housing authorities.
Are minority-serving institutions specifically included in eligibility?
Yes. The FOA lists several specialized categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions.
Are foreign organizations eligible to apply?
Yes. The FOA states that foreign organizations and foreign institutions are eligible to apply.
Can non-U.S. components of U.S. organizations participate?
Yes. The FOA notes that non-U.S. components of U.S. organizations may participate.
Are foreign components allowed under NIH policy?
Yes. The FOA indicates that foreign components (as defined by NIH policy) are allowed.
Where was the full announcement made available?
The full announcement was available through the NIH Grants Guide (a link was provided in the source information).
Who is listed as a contact for access or technical issues with the posting?
The NIH Office of Extramural Research webmaster contact information is provided for access or technical issues related to the posting.
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