Opportunity Information: Apply for PA 11 267
Apply for PA 11 267
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mechanistic Studies of Pain and Alcohol Dependence (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Jul 20, 2011 and posted on Jul 20, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Small businesses Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.
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Opportunity Summary:
The NIH grant opportunity "Mechanistic Studies of Pain and Alcohol Dependence (R01)" (Funding Opportunity Number PA 11-267) was a discretionary research grant announcement designed to support R01-level projects that dig into the biological and behavioral mechanisms connecting pain and alcohol use. The core idea behind the announcement is that chronic pain and alcohol dependence frequently show up together in real-world settings, but the direction of that relationship can vary from person to person. In some cases, heavy drinking or alcohol abuse comes first and is followed later by chronic pain. In other cases, chronic pain appears first and problematic alcohol use develops afterward, sometimes as a way of coping. Because these patterns are seen so consistently, the FOA calls for studies that move beyond simple correlation and instead explain how and why these conditions influence one another.
A key scientific rationale emphasized in the announcement is that pain signaling pathways and alcohol's rewarding or reinforcing effects overlap in the brain and nervous system. That overlap raises the possibility that living in a chronic pain state could shift alcohol use patterns, increase the motivation to drink, and ultimately raise the risk for alcohol dependence or addiction. At the same time, the FOA highlights the reverse pathway as equally important: long-term alcohol intoxication and established alcohol dependence can produce pain symptoms on their own and can worsen pain that originates from other causes. In practical terms, this means alcohol may sometimes be used in response to pain, yet also contribute to a cycle where pain sensitivity, pain complaints, or pain-related disability become more severe over time.
The specific objective of the FOA is to improve mechanistic understanding of the association between a person's propensity to drink alcohol and their pain responses, with an emphasis on genetic, pharmacological, and learning-related mechanisms. That framing points applicants toward projects that can identify underlying causal pathways, such as genetic factors that jointly influence pain sensitivity and alcohol-related behaviors, drug and receptor mechanisms that affect both nociception and reinforcement, and learning processes (for example, conditioning, negative reinforcement, or stress-related learning) that might connect pain relief, drinking behavior, escalation of use, and withdrawal-associated hyperalgesia. Overall, the announcement is aimed at clarifying the shared biology and behavioral drivers that could explain why pain and alcohol dependence so often interact and reinforce each other.
From an administrative standpoint, this was an NIH health-related funding opportunity under CFDA 93.273 (Alcohol Research Programs). It did not require cost sharing or matching. The FOA was posted and created on July 20, 2011, and the original and final closing date listed was September 7, 2014, with an archive date of October 8, 2014, meaning it is no longer an active competition in this exact form.
Eligibility was broad and included many common applicant types across academia, government, and the nonprofit and private sectors. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses) and small businesses, as well as state, county, city/township, special district governments, independent school districts, and public or tribal housing authorities. The FOA also explicitly included a wide range of additional eligible entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), federally recognized and other tribal organizations, faith-based or community-based organizations, U.S. territories or possessions, and regional organizations. Importantly, non-U.S. entities were also eligible: foreign organizations and foreign institutions could apply, and non-domestic components of U.S. organizations were also allowed.
The sponsoring agency was the National Institutes of Health. The public listing provided an NIH Office of Extramural Research contact route for technical problems accessing the announcement online (FBOWebmaster@OD.NIH.GOV) and pointed to the official NIH guide page for the full FOA text.
FAQs: Mechanistic Studies of Pain and Alcohol Dependence (R01) (PA-11-267)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled Mechanistic Studies of Pain and Alcohol Dependence (R01) and the Funding Opportunity Number is PA 11-267.
What type of grant mechanism does this opportunity support?
This announcement was designed to support R01-level discretionary research projects.
What is the main purpose of this FOA?
The FOA focuses on research that explains the biological and behavioral mechanisms that connect pain (especially chronic pain) and alcohol use/alcohol dependence, going beyond simple correlations to clarify how and why these conditions influence one another.
Why does the FOA emphasize moving beyond correlation?
The announcement notes that pain and alcohol dependence frequently co-occur in real-world settings, but the direction of the relationship varies. Because co-occurrence alone does not explain cause and effect, the FOA calls for studies that identify mechanistic, causal pathways linking alcohol-related behavior and pain responses.
What real-world patterns between pain and alcohol use does the FOA describe?
The FOA highlights that the sequence can differ across individuals. In some cases, heavy drinking or alcohol abuse occurs first and chronic pain appears later. In other cases, chronic pain appears first and problematic alcohol use develops afterward, sometimes as a coping strategy.
What scientific rationale supports studying pain and alcohol dependence together?
The FOA emphasizes that pain signaling pathways and alcohol's rewarding/reinforcing effects overlap in the brain and nervous system. This overlap suggests shared mechanisms that could help explain why chronic pain and alcohol dependence can interact and reinforce each other.
How might chronic pain affect alcohol use, according to the FOA?
The announcement raises the possibility that living in a chronic pain state could shift alcohol use patterns, increase motivation to drink, and raise risk for alcohol dependence or addiction.
How might long-term alcohol use affect pain, according to the FOA?
The FOA also emphasizes the reverse pathway: long-term alcohol intoxication and established alcohol dependence can produce pain symptoms and can worsen pain that originates from other causes.
Does the FOA describe a cycle between alcohol use and worsening pain?
Yes. In practical terms, it describes a situation where alcohol may be used in response to pain, while also contributing to a cycle in which pain sensitivity, pain complaints, or pain-related disability become more severe over time.
What is the specific objective of the FOA?
The specific objective is to improve mechanistic understanding of the association between a person's propensity to drink alcohol and their pain responses, emphasizing genetic, pharmacological, and learning-related mechanisms.
What kinds of mechanisms are specifically emphasized for proposed studies?
The FOA emphasizes three broad categories of mechanisms: (1) genetic factors that jointly influence pain sensitivity and alcohol-related behaviors, (2) pharmacological and receptor/drug mechanisms affecting both nociception and reinforcement, and (3) learning-related mechanisms.
What learning-related processes does the FOA mention?
The FOA gives examples of learning processes such as conditioning, negative reinforcement, and stress-related learning that might connect pain relief, drinking behavior, escalation of use, and withdrawal-associated hyperalgesia.
What broader goal does the FOA aim to achieve in the field?
Overall, the announcement is aimed at clarifying shared biology and behavioral drivers that could explain why pain and alcohol dependence so often interact and reinforce each other.
Which agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What CFDA program is associated with this FOA?
The FOA is listed under CFDA 93.273, identified as Alcohol Research Programs.
Was cost sharing or matching required?
No. The FOA stated that it did not require cost sharing or matching.
Is this funding opportunity still open?
No. The FOA is no longer active in this exact form. It was created and posted on July 20, 2011, had an original and final closing date of September 7, 2014, and an archive date of October 8, 2014.
Who was eligible to apply?
Eligibility was broad and included many applicant types across academia, government, and nonprofit/private sectors.
Are U.S. colleges and universities eligible?
Yes. Eligible applicants included public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. The FOA included nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. Eligible applicants included for-profit organizations (other than small businesses) and small businesses.
Are government entities eligible to apply?
Yes. The FOA included state governments, county governments, city/township governments, special district governments, and independent school districts, as well as public or tribal housing authorities.
Are minority-serving institutions and similar organizations included in eligibility?
Yes. The FOA explicitly listed eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal organizations eligible?
Yes. The FOA included federally recognized and other tribal organizations.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly included faith-based or community-based organizations.
Are U.S. territories or regional organizations eligible?
Yes. The FOA included eligibility for U.S. territories or possessions and regional organizations.
Can foreign organizations apply?
Yes. The FOA stated that foreign organizations and foreign institutions could apply, and that non-domestic components of U.S. organizations were also allowed.
Where can applicants get help with technical problems accessing the announcement online?
The public listing provided an NIH Office of Extramural Research contact route for technical issues: FBOWebmaster@OD.NIH.GOV.
Where is the official FOA text located?
The listing pointed to the official NIH guide page for the full FOA text.
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