Opportunity Information: Apply for PAS 08 187
Apply for PAS 08 187
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Medications Development for Polydrug Addiction Treatment (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 26, 2008.
- Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Small businesses City or township governments State governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Medications Development for Polydrug Addiction Treatment (R21) opportunity (Funding Opportunity Number PAS 08 187) is a National Institutes of Health grant announcement from the National Institute on Drug Abuse (NIDA) focused on early stage research aimed at finding and developing medications for people who are addicted to more than one substance at the same time. The central problem it targets is polydrug addiction, meaning concurrent dependence on combinations of alcohol, tobacco, illicit drugs, and/or prescription drugs. NIDA is looking for projects that can move the field toward practical pharmacological treatments that reflect the real world reality that many patients do not present with a single substance use disorder in isolation.
The scientific scope is broad but very clearly oriented toward medication discovery and development. Applications can propose novel clinical or preclinical testing of candidate medications, including proof of concept style studies that can justify larger follow on trials later. The announcement also explicitly encourages supporting work that makes medication development more feasible, such as developing or refining animal models that better capture polydrug use patterns, mechanisms, withdrawal, relapse, or drug interaction effects that occur when multiple substances are involved. Medicinal chemistry efforts are also within scope, which can include designing, optimizing, or characterizing compounds that might have activity across multiple addictive pathways or that are specifically intended to address combined substance use.
This funding uses the NIH Exploratory/Developmental Research Grant mechanism (R21). In practical terms, that means it is intended for exploratory, high impact ideas and early development work rather than large, fully mature programs. The R21 mechanism typically supports projects that generate key preliminary data, demonstrate feasibility, or validate a new approach that can later be expanded into a more definitive research project. This FOA runs in parallel with a companion announcement with the same scientific scope that uses the R01 mechanism (PAS 08 186), giving applicants a choice between an exploratory R21 approach and a more extensive R01 project structure depending on the maturity and scale of their proposed work.
In terms of funding, the announcement estimated that for Fiscal Year 2009 there would be about $3,000,000 total available to support projects across both this R21 FOA and the parallel R01 FOA. Because proposed projects can vary substantially in scope, the award size and project duration were expected to vary as well. Even so, the FOA provides a planning range by stating that, given typical budget patterns, NIH anticipated making roughly 4 to 7 total awards. It also notes that future funding levels and the number of awards would depend on yearly appropriations, which is standard language indicating that later year support is not guaranteed beyond the current budgeting context.
Key administrative details include that it is a discretionary grant program categorized under education and health, listed under CFDA 93.279 (Drug Abuse and Addiction Research Programs). The award ceiling shown is $200,000, and the opportunity does not require cost sharing or matching funds, which reduces barriers for applicants that may not have substantial non federal resources to contribute.
Eligibility is intentionally broad and includes many organization types that commonly apply to NIH programs. Eligible applicants include public and state controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status), for profit organizations other than small businesses, small businesses, state governments, county governments, city or township governments, special district governments, and independent school districts, along with public housing authorities and Indian housing authorities. The FOA also expands eligibility to include a wide range of mission focused and underserved community institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), federally recognized and other tribal governments and tribal organizations, faith based and community based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and even non U.S. entities (foreign organizations). This wide eligibility aligns with the public health nature of addiction research and the need for diverse research settings, populations, and scientific capabilities.
The timeline information provided indicates the opportunity was posted June 26, 2008, with an original and current closing date of September 7, 2011, and an archive date of October 8, 2011. While those dates mean the specific announcement is no longer open, the summary still reflects how NIDA framed its priorities at the time: developing medications that can address the complexity of multi substance addiction, and supporting innovative early stage studies that could unlock more definitive R01 level work later. The full announcement was hosted on the NIH Grants Guide, and the contact path referenced NIH Office of Extramural Research web support for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Medications Development for Polydrug Addiction Treatment (R21).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number listed is PAS 08 187.
Which agency and institute are offering this opportunity?
This is a National Institutes of Health (NIH) grant announcement from the National Institute on Drug Abuse (NIDA).
What problem area is this funding intended to address?
It targets polydrug addiction, meaning concurrent dependence on combinations of alcohol, tobacco, illicit drugs, and/or prescription drugs. The FOA emphasizes that many patients do not present with a single substance use disorder in isolation.
What is meant by “polydrug addiction” in this announcement?
Within this FOA, polydrug addiction refers to people who are addicted to more than one substance at the same time, including combinations across alcohol, tobacco, illicit substances, and prescription drugs.
What is the primary goal of the funded research?
The primary goal is to move the field toward practical pharmacological (medication) treatments that better reflect real-world multi-substance addiction patterns.
What types of studies are within the scientific scope?
The scope is broad but centered on medication discovery and development. The FOA includes support for:
- Novel clinical testing of candidate medications
- Preclinical testing of candidate medications
- Proof-of-concept studies that can justify larger follow-on trials
- Work that makes medication development more feasible, such as developing or refining animal models relevant to polydrug use
- Studies of mechanisms, withdrawal, relapse, and drug interaction effects when multiple substances are involved
- Medicinal chemistry efforts, including designing, optimizing, or characterizing compounds that may act across multiple addictive pathways or are intended for combined substance use
Does the FOA allow both clinical and preclinical research?
Yes. The announcement explicitly mentions both clinical and preclinical testing of candidate medications, including proof-of-concept style studies.
Is medicinal chemistry work allowed under this FOA?
Yes. The FOA states that medicinal chemistry is within scope, including designing, optimizing, or characterizing compounds aimed at addressing multiple addictive pathways or combined substance use.
Are animal model development or refinement projects considered responsive?
Yes. The FOA encourages supporting work that makes medication development more feasible, including developing or refining animal models that better capture polydrug use patterns and related mechanisms such as withdrawal, relapse, or drug interaction effects.
What grant mechanism is used for this opportunity?
This FOA uses the NIH Exploratory/Developmental Research Grant mechanism (R21).
What does it mean that this is an R21 opportunity?
As described in the summary, an R21 is intended for exploratory, high-impact ideas and early development work, typically aimed at generating key preliminary data, demonstrating feasibility, or validating a new approach that can later be expanded into a more definitive project.
Is there a related opportunity for larger or more mature projects?
Yes. This R21 FOA runs in parallel with a companion announcement with the same scientific scope that uses the R01 mechanism: PAS 08 186. Applicants could choose between an exploratory R21 approach and a more extensive R01 structure depending on project maturity and scale.
How much total funding was estimated to be available?
The FOA estimated that for Fiscal Year 2009 there would be about $3,000,000 total available to support projects across both this R21 FOA (PAS 08 187) and the parallel R01 FOA (PAS 08 186).
How many awards were anticipated?
Based on typical budget patterns, NIH anticipated making roughly 4 to 7 total awards across both the R21 and companion R01 announcements. The FOA also notes that award counts depend on annual appropriations.
What is the award ceiling listed for this opportunity?
The award ceiling shown is $200,000.
Are cost sharing or matching funds required?
No. The opportunity states that it does not require cost sharing or matching funds.
Under what category is this grant program listed?
It is described as a discretionary grant program categorized under education and health.
What is the CFDA number for this program?
The CFDA listing provided is 93.279 (Drug Abuse and Addiction Research Programs).
Who is eligible to apply?
Eligibility is broad. The FOA lists eligible applicants that include:
- Public and state controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status)
- For-profit organizations other than small businesses
- Small businesses
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities and Indian housing authorities
- Historically Black Colleges and Universities (HBCUs)
- Hispanic Serving Institutions
- Alaska Native and Native Hawaiian Serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Federally recognized and other tribal governments and tribal organizations
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
- Non-U.S. entities (foreign organizations)
Are foreign organizations eligible to apply?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized and other tribal governments and tribal organizations, as well as Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA lists faith-based and community-based organizations as eligible applicant types.
When was this opportunity posted?
The timeline provided indicates it was posted on June 26, 2008.
What was the closing date for applications?
The original and current closing date listed is September 7, 2011.
Is this specific funding opportunity still open?
No. The archive date is listed as October 8, 2011, and the closing date (September 7, 2011) has passed, indicating the specific announcement is no longer open.
Where was the full announcement hosted?
The full announcement was hosted on the NIH Grants Guide.
Who was referenced for help with access or linking issues?
The contact path referenced NIH Office of Extramural Research web support for access or linking issues.
Does the FOA guarantee future-year funding?
No. The summary notes that future funding levels and the number of awards depend on yearly appropriations, meaning later-year support is not guaranteed beyond the current budgeting context described.
Browse more opportunities from the same category: Education Health
Next opportunity: Integrating Biobehavioral and Sociocultural Research to Prevent HIV Transmission and Infection (R01)
Previous opportunity: Medications Development for Polydrug Addiction Treatment (R01)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAS 08 187
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAS 08 187) also looked into and applied for these:
| Funding Opportunity |
|---|
| Integrating Biobehavioral and Sociocultural Research to Prevent HIV Transmission and Infection (R01) Apply for PA 08 188 Funding Number: PA 08 188 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Integrating Biobehavioral and Sociocultural Research to Prevent HIV Transmission and Infection (R21) Apply for PA 08 189 Funding Number: PA 08 189 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Geographic and Contextual Influences on Energy Balance Related Health Behaviors (R01) Apply for PA 08 192 Funding Number: PA 08 192 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Geographic and Contextual Influences on Energy Balance Related Health Behaviors (R21) Apply for PA 08 193 Funding Number: PA 08 193 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Technological Innovations for Interdisciplinary Research Incorporating the Behavioral and Social Sciences (STTR R41/R42) Apply for PAR 08 201 Funding Number: PAR 08 201 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Pilot studies in Pancreatic Cancer (R21) Apply for PA 08 208 Funding Number: PA 08 208 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| PPilot studies in Pancreatic Cancer (R03) Apply for PA 08 209 Funding Number: PA 08 209 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Diet Induced Changes in Inflammation as Determinants of Colon Cancer (R01) Apply for PA 08 210 Funding Number: PA 08 210 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Diet Induced Changes in Inflammation as Determinants of Colon Cancer (R21) Apply for PA 08 211 Funding Number: PA 08 211 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Drug Abuse Prevention Intervention Research (R01) Apply for PA 08 217 Funding Number: PA 08 217 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse Prevention Intervention Research (R21) Apply for PA 08 218 Funding Number: PA 08 218 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Drug Abuse Prevention Intervention Research (R03) Apply for PA 08 219 Funding Number: PA 08 219 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Investigational Nutrigenetic Studies for Cancer Prevention (R01) Apply for PA 08 220 Funding Number: PA 08 220 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Investigational Nutrigenetic Studies for Cancer Prevention (R21) Apply for PA 08 221 Funding Number: PA 08 221 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Etiology, Prevention, and Treatment of Hepatocellular Carcinoma(R21) Apply for PA 08 244 Funding Number: PA 08 244 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R03) Apply for RFA DA 09 019 Funding Number: RFA DA 09 019 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01) Apply for RFA DA 09 017 Funding Number: RFA DA 09 017 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Physical Science Oncology Centers (U54) Apply for RFA CA 09 009 Funding Number: RFA CA 09 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $2,250,000 |
| NINR Mentored Research Scientist Development Award for Underrepresented or Disadvantaged Investigators (K01) Apply for PAR 05 135 Funding Number: PAR 05 135 Agency: National Institutes of Health Category: Education Health Funding Amount: $20,000 |
| NCI Transition Career Development Award to Promote Diversity (K22) Apply for PAR 08 047 Funding Number: PAR 08 047 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAS 08 187", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.