Opportunity Information: Apply for PA 14 049

  • The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Mentored Patient Oriented Research Career Development Award (Parent K23)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.398 Cancer Research Manpower 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
  • This funding opportunity was created on May 2, 2014 and posted on Dec 19, 2013.
  • Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) County governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Mentored Patient Oriented Research Career Development Award (Parent K23) is an NIH career development grant designed to help early-stage clinician-researchers build the skills, experience, and research trajectory needed to become independent investigators in patient-oriented research. In practical terms, it is meant for people who already hold a clinical doctoral degree and have decided to make research involving human participants the center of their long-term career. The K23 emphasizes structured mentorship and a defined career development plan, pairing a developing investigator with experienced mentors while the candidate conducts a focused research project that directly involves patients or human subjects and is grounded in clinical questions.

This opportunity is offered by the National Institutes of Health as a discretionary grant program and is framed as a mentored career development award rather than a traditional standalone research project grant. The core goal is not simply to fund a single study, but to create protected time and a training pathway so the awardee can deepen their methodological expertise, publish, build a track record in patient-oriented work, and transition toward independent funding. It is specifically aligned with patient-oriented research; clinicians who are looking to develop a research career that is primarily laboratory-based or otherwise outside the patient-oriented definition are directed instead to the NIH Parent K08 mechanism, which is aimed at mentored clinical scientists in non-patient-oriented biomedical research.

The funding announcement is identified as PA 14 049, titled "Mentored Patient Oriented Research Career Development Award (Parent K23)." It was posted on December 19, 2013, with a creation date of May 2, 2014. The original closing date and the final listed closing date were both January 7, 2017, and the opportunity was archived on February 7, 2017, meaning this specific announcement is no longer open under those dates. Even so, the K23 mechanism itself is a long-running NIH program, and applicants typically look for the most current active FOA and institute-specific guidance when preparing an application.

A notable feature of the Parent K23 is that it spans many NIH Institutes and Centers, which is reflected in the long list of CFDA program numbers associated with it. These include programs connected to environmental health, oral health, deafness and communication disorders, complementary and integrative health, sleep disorders, mental health, alcohol, drug abuse, technological innovations for human health, nursing research, cancer research training, heart/lung/blood diseases, arthritis and musculoskeletal conditions, diabetes and kidney diseases, neurological disorders, allergy and infectious diseases, child health, aging, and vision research, among others. In other words, the mechanism is broadly available across disease areas and scientific domains, as long as the proposed work fits patient-oriented research and aligns with the mission and priorities of the specific NIH Institute or Center that would potentially fund it.

Eligibility in the announcement is broad at the organizational level. Eligible applicant organizations include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), and multiple levels of government such as state, county, city or township, and special district governments, as well as eligible tribal governments and tribal organizations. The FOA also explicitly lists categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and U.S. territories or possessions. At the same time, non-U.S. (foreign) institutions are not eligible to apply as the applicant organization, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components are allowed under NIH policy as defined in the NIH Grants Policy Statement, which can matter for certain collaborations, data sources, or specialized expertise that resides outside the United States.

There is no cost sharing or matching requirement listed for this opportunity, which generally means applicants are not required to bring non-federal matching funds as a condition of the award. Budget and programmatic details can vary depending on which NIH Institute or Center is most appropriate for the topic, so the announcement stresses that prospective candidates should contact relevant NIH staff for Institute/Center-specific expectations, including budgetary guidelines and any special requirements. That kind of early communication is often important for confirming fit, understanding institute priorities, and clarifying how patient-oriented research is being interpreted for a given scientific area.

For official details, the announcement points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-14-049.html. The contact information included is primarily technical support: applicants who have trouble accessing the announcement or linking to it are directed to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV. For scientific and programmatic questions, the FOA indicates that candidates should consult the Institute/Center-specific staff contacts referenced in the announcement materials.

Frequently Asked Questions (FAQs): Mentored Patient Oriented Research Career Development Award (Parent K23) - PA-14-049

1) What is the Mentored Patient Oriented Research Career Development Award (Parent K23)?

The Parent K23 is an NIH mentored career development award intended to help early-stage clinician-researchers develop into independent investigators in patient-oriented research. It supports a structured mentorship arrangement and a defined career development plan while the candidate conducts a focused research project involving human participants or human subjects and rooted in clinical questions.

2) What is the main purpose of the K23 award?

The core goal is career development rather than simply funding a single standalone research project. The K23 is designed to provide protected time and a training pathway so the awardee can build methodological expertise, publish patient-oriented research, develop a track record, and transition toward independent funding.

3) Who is the K23 intended for?

It is meant for individuals who already hold a clinical doctoral degree and have committed to making research involving human participants the center of their long-term career. The award emphasizes mentored development for clinician-researchers building a patient-oriented research trajectory.

4) What does "patient-oriented research" mean in the context of this announcement?

Based on the announcement description, patient-oriented research is research that directly involves patients or human subjects and is grounded in clinical questions. The K23 is specifically aligned with this type of research.

5) How is the K23 different from a traditional NIH research grant?

The Parent K23 is framed as a mentored career development award rather than a traditional research project grant. It emphasizes structured mentorship and a career development plan alongside a focused patient-oriented research project, with the broader objective of building independence over time.

6) If my work is not patient-oriented, is the K23 still a fit?

The announcement indicates that clinicians aiming for a primarily laboratory-based research career or research outside the patient-oriented definition are directed to the NIH Parent K08 mechanism instead, which is aimed at mentored clinical scientists in non-patient-oriented biomedical research.

7) What is the funding announcement number and title for this opportunity?

The funding announcement is PA 14 049, titled "Mentored Patient Oriented Research Career Development Award (Parent K23)."

8) When was PA-14-049 posted and created?

The announcement was posted on December 19, 2013, with a creation date of May 2, 2014.

9) Is PA-14-049 currently open for applications?

No. The original closing date and the final listed closing date were both January 7, 2017, and the opportunity was archived on February 7, 2017. That means this specific announcement is no longer open under those dates.

10) If PA-14-049 is archived, can someone still pursue a K23?

Yes, in the sense that the K23 mechanism is described as a long-running NIH program. Applicants are typically expected to look for the most current active Funding Opportunity Announcement (FOA) and Institute-specific guidance when preparing an application.

11) Which agency offers this opportunity?

This opportunity is offered by the National Institutes of Health (NIH) as a discretionary grant program.

12) Does the Parent K23 apply to only one NIH Institute or Center?

No. The announcement describes the Parent K23 as spanning many NIH Institutes and Centers, which is reflected by a long list of associated CFDA program numbers covering many health and research areas.

13) What research areas does the Parent K23 cover?

The mechanism is broadly available across many disease areas and scientific domains, as long as the proposed work fits patient-oriented research and aligns with the mission and priorities of the NIH Institute or Center that would potentially fund it. The announcement references program areas including (among others) environmental health, oral health, deafness and communication disorders, complementary and integrative health, sleep disorders, mental health, alcohol, drug abuse, technological innovations for human health, nursing research, cancer research training, heart/lung/blood diseases, arthritis and musculoskeletal conditions, diabetes and kidney diseases, neurological disorders, allergy and infectious diseases, child health, aging, and vision research.

14) What types of organizations are eligible to apply?

Eligibility is broad at the organizational level. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, and for-profit organizations (including small businesses). Multiple levels of government are also eligible, including state, county, city or township, and special district governments, as well as eligible tribal governments and tribal organizations.

15) Are minority-serving institutions and community-based organizations included as eligible applicants?

Yes. The FOA explicitly lists categories including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). It also includes faith-based or community-based organizations and U.S. territories or possessions.

16) Are foreign (non-U.S.) institutions eligible to apply as the applicant organization?

No. The announcement states that non-U.S. (foreign) institutions are not eligible to apply as the applicant organization, and non-U.S. components of U.S. organizations are not eligible to apply.

17) Can foreign components be involved at all?

Yes. The announcement notes that foreign components are allowed under NIH policy as defined in the NIH Grants Policy Statement. This can matter for collaborations, data sources, or specialized expertise located outside the United States.

18) Is cost sharing or matching required?

No. The opportunity indicates there is no cost sharing or matching requirement listed, meaning applicants generally are not required to provide non-federal matching funds as a condition of the award.

19) Are budget rules and expectations the same across NIH?

Not necessarily. The announcement stresses that budget and programmatic details can vary depending on the NIH Institute or Center most appropriate for the topic. Prospective candidates are encouraged to contact relevant NIH staff for Institute/Center-specific expectations, including budgetary guidelines and any special requirements.

20) Why does the announcement recommend contacting NIH staff before applying?

Early communication is described as important for confirming fit, understanding Institute priorities, clarifying how patient-oriented research is interpreted for the relevant scientific area, and understanding Institute/Center-specific expectations such as budget guidelines and special requirements.

21) Where can the official archived announcement be found?

The announcement points to the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/pa-files/PA-14-049.html

22) Who should be contacted for technical problems accessing the announcement?

For trouble accessing the announcement or linking to it, the FOA directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

23) Who should be contacted for scientific or programmatic questions?

For scientific and programmatic questions, the FOA indicates that candidates should consult the Institute/Center-specific staff contacts referenced in the announcement materials.

24) What kind of support structure is emphasized by the K23?

The K23 emphasizes structured mentorship and a defined career development plan, pairing a developing investigator with experienced mentors while the candidate conducts a focused patient-oriented research project.

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PHS 2014 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42 Apply for PA 14 072

Funding Number: PA 14 072
Agency: National Institutes of Health
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PHS 2014 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44) Apply for PA 14 071

Funding Number: PA 14 071
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
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Change of Grantee Organization (Type 7 Parent) Apply for PA 14 078

Funding Number: PA 14 078
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Successor in Interest (Type 6 Parent) Apply for PA 14 079

Funding Number: PA 14 079
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp) Apply for PA 14 077

Funding Number: PA 14 077
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
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Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 14 147

Funding Number: PA 14 147
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health Related Research (Parent F31 Diversity) Apply for PA 14 148

Funding Number: PA 14 148
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 14 149

Funding Number: PA 14 149
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual Doctoral Degree Fellowship (Parent F30) Apply for PA 14 150

Funding Number: PA 14 150
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Predoctoral Training in Biomedical Big Data Science (T32) Apply for RFA HG 14 004

Funding Number: RFA HG 14 004
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
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Funding Number: RFA HG 14 005
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
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NIH Research Evaluation and Commercialization Hub (REACH) Awards (U01) Apply for RFA OD 14 005

Funding Number: RFA OD 14 005
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Funding Number: PAR 14 201
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Funding Number: PA 15 083
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Funding Number: PA 15 144
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