Opportunity Information: Apply for PAR 16 333
Apply for PAR 16 333
- The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847,.
- This funding opportunity was created on Jun 15, 2016 and posted on Jun 15, 2016.
- Applicants must submit their applications by Sep 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The funding opportunity titled "Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)" (Funding Opportunity Number PAR-16-333) is a discretionary NIH grant program that supports human research focused on why people with type 2 diabetes face a higher risk of neurocognitive impairment. The core purpose of the announcement is to invite applications that can clarify the underlying causes (etiology) and biological mechanisms (pathogenesis) linking metabolic dysfunction in type 2 diabetes to changes in brain health and cognition. In practical terms, the FOA is aimed at studies that go beyond simply observing that diabetes and cognitive decline are associated; it is looking for well-designed human investigations that can help explain how and why metabolic factors in diabetes contribute to neurocognitive complications.
As an R01 mechanism, the opportunity is intended for substantial, hypothesis-driven research projects, typically involving rigorous study designs, robust analytic plans, and a clear strategy for generating impactful, generalizable findings. The title and framing emphasize "ancillary studies," which generally means projects that add value to existing cohorts, clinical trials, longitudinal studies, or established research networks by leveraging already-collected data, stored biospecimens, or ongoing participant follow-up. Ancillary studies often aim to answer mechanistic questions efficiently by building on infrastructure that is already in place, such as adding specialized neurocognitive testing, neuroimaging, metabolic phenotyping, or biomarker analyses that were not part of the parent study. While the short description provided here does not list specific required methods, the scientific theme strongly suggests a focus on metabolic pathways and their downstream effects on the brain, including potential links through insulin resistance, glycemic variability, inflammation, vascular dysfunction, dyslipidemia, mitochondrial stress, or other diabetes-related physiological changes that could plausibly affect cognition.
The awarding agency is the U.S. Department of Health and Human Services, National Institutes of Health (listed as HHS-NIH11). The activity category is classified under Food and Nutrition, Health, and the opportunity is associated with CFDA numbers 93.847 (Diabetes, Endocrinology and Metabolic Diseases Research) and 93.859 (Biomedical Research and Research Training), reflecting its alignment with NIH priorities in metabolic disease and biomedical mechanisms. The FOA was posted and created on June 15, 2016, and the closing date shown is September 7, 2019 (both original and current), indicating the timeframe during which applications were accepted under that specific posting.
Eligibility is broad and includes many types of domestic organizations that typically apply for NIH research funding. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA's additional eligibility language. This wide eligibility range signals that NIH was seeking to attract strong scientific proposals from academic medical centers, universities, research institutes, healthcare systems, and qualified nonprofit or commercial research organizations capable of conducting sophisticated human studies.
In summary, PAR-16-333 supports R01-level, human-focused ancillary research designed to unpack the metabolic drivers of cognitive and neurological complications in type 2 diabetes. The program is positioned to fund projects that can meaningfully advance understanding of mechanisms and causal pathways, ultimately helping the field move toward better identification of at-risk individuals and informing targets for prevention or intervention aimed at preserving cognitive function in people living with type 2 diabetes.
Frequently Asked Questions (FAQs)
What is the official title of this funding opportunity?
The opportunity is titled "Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-16-333.
Which federal agency is offering this grant?
The awarding agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), listed as HHS-NIH11.
What type of grant mechanism is this?
This opportunity uses the NIH R01 mechanism, which is intended for substantial, hypothesis-driven research projects with rigorous designs and analytic plans.
What is the main scientific focus of PAR-16-333?
It supports human research aimed at understanding why people with type 2 diabetes have a higher risk of neurocognitive impairment, with an emphasis on identifying the underlying causes (etiology) and biological mechanisms (pathogenesis) linking metabolic dysfunction to brain health and cognition.
Is this opportunity focused on association studies or mechanistic studies?
The focus is on studies that go beyond observing associations between diabetes and cognitive decline. The FOA is aimed at well-designed human investigations that help explain how and why metabolic factors in type 2 diabetes contribute to neurocognitive complications.
What does "ancillary studies" mean in this FOA?
"Ancillary studies" generally refers to research that adds value to existing resources, such as cohorts, clinical trials, longitudinal studies, or established research networks. These projects often leverage already-collected data, stored biospecimens, or ongoing participant follow-up, and may add new measures not included in the parent study.
What kinds of research activities might an ancillary study include under this theme?
While specific methods are not listed in the provided description, the scientific framing suggests ancillary activities that could include adding specialized neurocognitive testing, neuroimaging, metabolic phenotyping, or biomarker analyses to an existing human study to probe mechanisms linking metabolic dysfunction to brain outcomes.
What metabolic or biological pathways are highlighted as relevant to the research theme?
The opportunity highlights potential mechanistic links through pathways such as insulin resistance, glycemic variability, inflammation, vascular dysfunction, dyslipidemia, and mitochondrial stress, as well as other diabetes-related physiological changes that could plausibly affect cognition.
What population is the research focused on?
The FOA is centered on people with type 2 diabetes and the elevated risk of neurocognitive impairment in this population, within the context of human research.
What is the ultimate goal or expected impact of funded projects?
The goal is to advance understanding of mechanisms and causal pathways linking metabolic dysfunction in type 2 diabetes to brain and cognitive changes, supporting progress toward better identification of at-risk individuals and informing potential prevention or intervention targets to preserve cognitive function.
What is the activity category for this opportunity?
The activity category is classified under Food and Nutrition and Health.
Which CFDA numbers are associated with this funding opportunity?
This opportunity is associated with CFDA numbers 93.847 (Diabetes, Endocrinology and Metabolic Diseases Research) and 93.859 (Biomedical Research and Research Training).
When was this FOA posted?
The FOA was posted (and created) on June 15, 2016.
What is the closing date listed for this opportunity?
The closing date shown is September 7, 2019 (both original and current, as stated in the provided information).
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations, including:
- State, county, city, township, and special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments and other tribal organizations
- Nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified)
- For-profit organizations other than small businesses
- Small businesses
- Other entities as described in the FOA's additional eligibility language
Does the FOA suggest what types of organizations are likely to submit strong proposals?
The description indicates NIH was seeking strong proposals from organizations capable of conducting sophisticated human studies, such as universities, academic medical centers, research institutes, healthcare systems, and qualified nonprofit or commercial research organizations.
Does this opportunity support human research?
Yes. The program description explicitly states it supports human research focused on neurocognitive risks in type 2 diabetes and the metabolic mechanisms that may drive those complications.
What makes a project a good fit based on the description provided?
Based on the description, a strong fit would be an R01-level, hypothesis-driven human study that leverages an existing study platform (as an ancillary study) and is designed to clarify mechanisms connecting metabolic dysfunction in type 2 diabetes to brain health and cognition.
Browse more opportunities from the same agency: HHS-NIH11
Browse more opportunities from the same category: Food and Nutrition, Health
Next opportunity: Prometheus
Previous opportunity: Cutthroat trout hybridization and population genetics in the Lamar River
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 16 333
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 16 333) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pediatric Centers of Excellence in Nephrology (P50) Apply for RFA DK 16 032 Funding Number: RFA DK 16 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| George M. O'Brien Kidney Research Core Centers (P30) Apply for RFA DK 16 031 Funding Number: RFA DK 16 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 16 022 Funding Number: RFA DK 16 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24) Apply for RFA DK 16 510 Funding Number: RFA DK 16 510 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,062,000 |
| NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01) Apply for RFA DK 16 029 Funding Number: RFA DK 16 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $293,000 |
| Coordinating Unit for the Mouse Metabolic Phenotyping Centers (U24) Apply for RFA DK 16 034 Funding Number: RFA DK 16 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,212,563 |
| Coordinating Unit for Diabetic Complications Consortium (U24) Apply for RFA DK 16 036 Funding Number: RFA DK 16 036 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $3,122,000 |
| APOL1 Long-term Kidney Transplantation Outcomes Network Scientific and Data Research Center (APOLLO SDRC) (Collaborative U01) Apply for RFA DK 16 024 Funding Number: RFA DK 16 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) Apply for RFA DK 16 505 Funding Number: RFA DK 16 505 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $45,000,000 |
| Limited Competition: Revision Application for the Human Islet Research Network Coordinating Center (U01) Apply for RFA DK 17 501 Funding Number: RFA DK 17 501 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $4,737,500 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20) Apply for RFA DK 17 002 Funding Number: RFA DK 17 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| George M. O'Brien Kidney Research Core Centers (P30) Apply for RFA DK 17 005 Funding Number: RFA DK 17 005 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) Apply for RFA DK 17 508 Funding Number: RFA DK 17 508 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $27,000,000 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U24) Apply for RFA HL 17 028 Funding Number: RFA HL 17 028 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $3,245,000 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM2) Apply for RFA HL 17 031 Funding Number: RFA HL 17 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM1) Apply for RFA HL 17 026 Funding Number: RFA HL 17 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U54) Apply for RFA HL 17 025 Funding Number: RFA HL 17 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R01) Apply for RFA HL 17 029 Funding Number: RFA HL 17 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (P50) Apply for RFA HL 17 032 Funding Number: RFA HL 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R24) Apply for RFA HL 17 030 Funding Number: RFA HL 17 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 16 333", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.