Opportunity Information: Apply for RFA RM 15 001
Apply for RFA RM 15 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Metabolomics Core for the Undiagnosed Diseases Network (UDN) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jan 21, 2015 and posted on Jan 21, 2015.
- Applicants must submit their applications by Apr 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) Small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities City or township governments Private institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) announced this funding opportunity to create a dedicated Metabolomics Core for the Undiagnosed Diseases Network (UDN) under a U01 cooperative agreement mechanism. The main purpose is to strengthen the UDN's ability to diagnose patients who have remained undiagnosed despite extensive clinical workups by adding advanced metabolomics capabilities. In practice, the Metabolomics Core would function as a network-wide resource that supports UDN clinical sites and investigators by generating, interpreting, and integrating metabolomics data with existing clinical and laboratory findings, ultimately helping to identify diagnostic signatures and shed light on disease mechanisms.
Applications are expected to lay out a clear plan to deliver comprehensive metabolomics services to the UDN, including analytical methods, technologies, and domain expertise. The Core is meant to help in two closely related ways: first, by supporting clinical diagnosis through robust metabolic profiling and interpretation, and second, by enabling deeper investigation into the biological mechanisms behind unusual patient phenotypes. Because UDN cases often involve extremely rare disorders, and sometimes conditions that may be essentially unique, the FOA emphasizes the need for flexible and highly specialized capabilities. Applicants should therefore address how they will develop and run "boutique" assays tailored to unusual metabolic questions, including methods to measure both typical metabolites and abnormal or unexpected compounds that may appear in the diseased metabolome.
This opportunity is a discretionary health-related award with an expected single awardee. The estimated total funding is $1,000,000, with an award ceiling of $1,000,000, and there is no cost sharing or matching requirement. The funding instrument is a cooperative agreement, which generally implies substantial NIH involvement in the project’s coordination or oversight compared with a standard grant, consistent with the Core serving a larger NIH-supported network.
The FOA (Funding Opportunity Number RFA-RM-15-001) was posted on January 21, 2015, created the same day, and had an original and current closing date of April 15, 2015. The archive date is May 16, 2015. The administering agency is NIH, and the CFDA number listed is 93.310 (Trans-NIH Research Support).
Eligibility is broad across many organization types, including nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, various levels of government (state, county, city/township, special district), tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and institutions of higher education (both private and public/state-controlled). The eligibility language also notes inclusion of various serving institutions (for example, HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions), as well as faith-based or community-based organizations and eligible federal agencies. However, foreign entities are explicitly not eligible: non-U.S. organizations and non-U.S. components of U.S. organizations cannot apply, and foreign components as defined by NIH policy are not allowed.
The full announcement was provided through the NIH Grants Guide, and assistance with accessing or linking to the announcement was directed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is this funding opportunity trying to support?
This NIH funding opportunity supports the creation of a dedicated Metabolomics Core for the Undiagnosed Diseases Network (UDN). The goal is to strengthen the UDN's ability to diagnose patients who remain undiagnosed after extensive clinical workups by adding advanced metabolomics capabilities.
What is the Metabolomics Core expected to do for the UDN?
The Metabolomics Core is expected to function as a network-wide resource for UDN clinical sites and investigators. It would generate, interpret, and integrate metabolomics data with existing clinical and laboratory findings to help identify diagnostic signatures and provide insight into disease mechanisms.
How will the Metabolomics Core help with diagnosis?
The Core is intended to support clinical diagnosis by providing robust metabolic profiling and interpretation, and by integrating metabolomics results with other patient data already available through the UDN.
How will the Metabolomics Core help with research into disease mechanisms?
In addition to diagnosis support, the Core is also intended to enable deeper investigation into the biological mechanisms behind unusual patient phenotypes by using metabolomics data to shed light on underlying pathways and processes.
What types of metabolomics capabilities does NIH emphasize for this Core?
The FOA emphasizes flexible and highly specialized capabilities because UDN cases often involve extremely rare disorders and sometimes conditions that may be essentially unique. Applicants are expected to describe advanced metabolomics services, including analytical methods, technologies, and relevant domain expertise.
What does the FOA mean by "boutique" assays?
Based on the FOA description, "boutique" assays refer to tailored metabolomics assays designed to address unusual or case-specific metabolic questions in UDN patients. The FOA highlights the need to measure both typical metabolites and abnormal or unexpected compounds that may appear in the diseased metabolome.
Is this Core meant to serve a single site or the full UDN?
The Metabolomics Core is described as a network-wide resource, meaning it is intended to support UDN clinical sites and investigators across the network rather than serving only one local site.
What funding mechanism is being used?
The funding instrument is a U01 cooperative agreement mechanism. The FOA notes that a cooperative agreement generally implies substantial NIH involvement in project coordination and/or oversight compared with a standard grant, which aligns with the Core serving a larger NIH-supported network.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-RM-15-001.
Which agency is administering this opportunity?
The administering agency is the National Institutes of Health (NIH).
What is the CFDA number listed for this opportunity?
The CFDA number listed is 93.310 (Trans-NIH Research Support).
How many awards does NIH expect to make?
This opportunity is described as an expected single awardee, indicating NIH anticipated making one award.
How much funding is available?
The estimated total funding is $1,000,000. The award ceiling is also $1,000,000.
Is there a cost sharing or matching requirement?
No. The FOA states there is no cost sharing or matching requirement.
What are the key dates for this FOA?
The FOA was posted on January 21, 2015, and created the same day. The original closing date and current closing date were April 15, 2015. The archive date is May 16, 2015.
Where was the full announcement published?
The full announcement was provided through the NIH Grants Guide.
Who is eligible to apply?
Eligibility is broad and includes many organization types such as nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, institutions of higher education (public/state-controlled and private), and various government entities (state, county, city/township, special district). It also includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and independent school districts. The eligibility language also notes various serving institutions (including HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions), as well as faith-based or community-based organizations and eligible federal agencies.
Are foreign organizations eligible to apply?
No. Foreign entities are explicitly not eligible. Non-U.S. organizations and non-U.S. components of U.S. organizations cannot apply, and foreign components (as defined by NIH policy) are not allowed.
Does the FOA allow non-U.S. components of U.S. organizations to apply?
No. The FOA explicitly states that non-U.S. components of U.S. organizations cannot apply.
Does the FOA allow foreign components under NIH policy?
No. The FOA indicates that foreign components, as defined by NIH policy, are not allowed.
What should an application include, based on the FOA description?
Applications are expected to present a clear plan to deliver comprehensive metabolomics services to the UDN. This includes describing analytical methods, technologies, and domain expertise, and explaining how the Core will generate, interpret, and integrate metabolomics data with existing clinical and laboratory findings. Applicants are also expected to address how they will develop and run flexible "boutique" assays tailored to unusual metabolic questions.
What kinds of metabolites or compounds should the Core be prepared to measure?
The FOA emphasizes measuring both typical metabolites and abnormal or unexpected compounds that may appear in the diseased metabolome, reflecting the rare and unusual nature of many UDN cases.
Why does NIH emphasize flexibility and specialization for this Core?
The FOA notes that UDN cases often involve extremely rare disorders, and sometimes conditions that may be essentially unique. This drives the need for flexible, highly specialized metabolomics capabilities and tailored assays.
Where can someone get help accessing or linking to the announcement?
The FOA indicates that assistance with accessing or linking to the announcement was directed to the NIH Office of Extramural Research (OER) webmaster contact.
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