Opportunity Information: Apply for RFA MH 14 180
Apply for RFA MH 14 180
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methodologies and Formative Work for Combination HIV Prevention Approaches (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on May 2, 2013 and posted on May 2, 2013.
- Applicants must submit their applications by Sep 3, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Methodologies and Formative Work for Combination HIV Prevention Approaches (R01)" (Funding Opportunity Number RFA-MH-14-180) supports research aimed at improving how combination HIV prevention strategies are designed, carried out, and evaluated. The central idea behind the announcement is that meaningful, sustained reductions in HIV incidence are most likely when prevention efforts use multiple interventions together, rather than relying on a single approach. Over the past several years, HIV prevention and treatment have increasingly blended biomedical tools with behavioral and community-engagement components, especially with advances such as pre-exposure prophylaxis (PrEP) and Treatment as Prevention (TasP). These advances have shifted the field toward thinking in terms of integrated packages of prevention activities that work across individual, clinical, and community levels.
A major focus of the opportunity is the growing real-world push by local, state, and federal programs to implement community-wide prevention efforts. These efforts are shaped by evidence that prevention impact depends not only on the availability of biomedical tools, but also on whether people start and stay on prevention or treatment services. For example, PrEP only reduces risk if it is taken consistently and supported by appropriate clinical follow-up, and TasP depends heavily on people being diagnosed, linked to care, retained in care, and achieving viral suppression. NIH is emphasizing that combination prevention must include both biomedical and behavioral interventions, and it often needs additional elements that address social, economic, and structural factors that drive HIV risk and transmission, such as stigma, housing instability, access barriers, discrimination, poverty, and unequal healthcare availability.
The announcement recognizes that combination approaches are complicated because they rely on the synergy of multiple parts. When several interventions operate at once, it becomes harder to answer key scientific and practical questions: which components matter most, how they interact, what level of coverage is required, how implementation quality affects outcomes, and how to measure success in ways that reflect real community impact. Because of that complexity, this FOA is specifically oriented toward methodological research, formative research, and implementation-focused work that can clarify the processes and outcomes of combination prevention efforts. In practical terms, NIH is looking for studies that strengthen the scientific foundation for combining interventions, help programs understand how to tailor packages to specific populations and settings, and improve the ability to evaluate these multi-component strategies rigorously.
This is an R01 grant mechanism, meaning it is intended for substantial, hypothesis-driven or well-justified research projects. The total estimated funding for the FOA is $2.2 million, with an award ceiling of $500,000 (as listed in the source data). There is no cost sharing or matching requirement. The opportunity was posted May 2, 2013, with an original and current closing date of September 3, 2013, and an archive date of October 4, 2013, indicating the announcement is no longer active but remains informative as a model for similar NIH initiatives.
Eligibility is broad and includes many types of organizations and government entities. Eligible applicants include nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, small businesses, for-profit organizations (other than small businesses), independent school districts, and various levels of government such as city/township, county, state, and special district governments. It also includes public housing authorities/Indian housing authorities and federally recognized Native American tribal governments, as well as tribal organizations that are not federally recognized. The FOA also explicitly includes a wide range of mission- and population-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities (foreign organizations and foreign institutions) may apply, foreign components are allowed under NIH policy, and non-U.S. components of U.S. organizations may participate, reflecting NIH interest in methodological and implementation insights that may be relevant across diverse epidemic contexts.
The FOA is associated with NIH program areas reflected in the listed CFDA numbers: 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research. This mix signals that NIH views combination HIV prevention as inherently interdisciplinary, spanning behavioral and mental health considerations, clinical and public health prevention science, and infectious disease research more broadly. Applicants were directed to the full announcement on the NIH Grants Guide website for complete instructions, and the contact point provided is the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
In short, this grant opportunity is designed to push the field beyond simply proving that individual HIV prevention tools work, and toward the harder but more impactful task of figuring out how to assemble, adapt, and implement multi-part prevention packages at scale. The emphasis is on generating the methodological and formative evidence needed to make combination prevention approaches practical, measurable, and effective in real communities, especially as public health agencies increasingly invest in wide-reaching strategies intended to lower HIV incidence at the population level.
FAQs: Methodologies and Formative Work for Combination HIV Prevention Approaches (R01) - RFA-MH-14-180
What is the title and funding opportunity number for this NIH grant?
The funding opportunity is titled "Methodologies and Formative Work for Combination HIV Prevention Approaches (R01)" and the Funding Opportunity Number is RFA-MH-14-180.
What is the main goal of this funding opportunity?
The goal is to support research that improves how combination HIV prevention strategies are designed, implemented, and evaluated. The opportunity focuses on strengthening the methodological and formative evidence needed to make multi-component prevention packages practical, measurable, and effective in real communities.
What does "combination HIV prevention" mean in this context?
Combination HIV prevention refers to using multiple interventions together rather than relying on a single approach. The FOA reflects the idea that sustained reductions in HIV incidence are most likely when prevention efforts integrate interventions that can operate across individual, clinical, and community levels.
Why is NIH emphasizing combination approaches instead of single interventions?
The announcement is built around the premise that community-level reductions in HIV incidence are more likely when multiple prevention components work together. It also reflects the reality that the impact of biomedical tools depends heavily on whether people start and stay engaged in prevention or treatment services.
How do biomedical tools like PrEP and TasP fit into the FOA?
Advances such as pre-exposure prophylaxis (PrEP) and Treatment as Prevention (TasP) have helped shift the field toward integrated prevention packages. The FOA highlights that PrEP only reduces risk if taken consistently with appropriate clinical follow-up, and TasP depends on diagnosis, linkage to care, retention in care, and viral suppression.
Does NIH expect projects to include behavioral or community components?
Yes. NIH emphasizes that combination prevention must include both biomedical and behavioral interventions, and often needs additional elements that address social, economic, and structural drivers of HIV risk and transmission.
What kinds of social or structural factors are mentioned as important to address?
The FOA notes factors such as stigma, housing instability, access barriers, discrimination, poverty, and unequal healthcare availability as examples of social, economic, and structural issues that can shape HIV risk, transmission, and engagement in prevention or treatment.
What makes combination prevention difficult to study and evaluate?
Combination approaches are complex because they rely on the synergy of multiple parts. When several interventions operate at the same time, it becomes harder to determine which components matter most, how components interact, what coverage levels are required, how implementation quality affects outcomes, and how to measure success in ways that reflect real community impact.
What type of research is this FOA primarily seeking?
This FOA is specifically oriented toward methodological research, formative research, and implementation-focused work. The intent is to clarify both processes and outcomes for multi-component prevention efforts and improve the rigor of evaluation for these approaches.
What does "methodological" research mean here?
Based on the description, "methodological" work refers to research that improves the scientific and evaluation methods needed to study combination prevention. This includes developing or strengthening ways to assess which components drive impact, how interventions interact, what coverage is needed, and how to measure community-level outcomes when interventions are delivered as a package.
What does "formative" research mean in the context of this FOA?
In this FOA, formative research refers to work that helps programs understand how to tailor and assemble prevention packages for specific populations and settings, and how to implement them in ways that are practical and relevant to real-world community conditions.
What is the grant mechanism used for this opportunity?
The mechanism is an NIH R01, which is intended for substantial, hypothesis-driven or otherwise well-justified research projects.
How much funding is available under this FOA?
The total estimated funding for the FOA is $2.2 million.
Is there an award ceiling for individual grants?
Yes. The award ceiling is listed as $500,000 in the source data provided.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement for this opportunity.
When was the opportunity posted, and what were the key dates?
The opportunity was posted on May 2, 2013. The original and current closing date was September 3, 2013, and the archive date was October 4, 2013.
Is this funding opportunity currently active?
No. The archive date (October 4, 2013) indicates the announcement is no longer active, though it remains informative as a model for similar NIH initiatives.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, small businesses, for-profit organizations (other than small businesses), independent school districts, and multiple levels of government (city/township, county, state, and special district governments). Public housing authorities/Indian housing authorities are also eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and tribal organizations that are not federally recognized are also included as eligible applicants.
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly includes faith-based organizations and community-based organizations among eligible applicants.
Are minority-serving institutions specifically included in eligibility?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and Tribally Controlled Colleges and Universities (TCCUs).
Can U.S. territories or possessions apply?
Yes. U.S. territories or possessions are explicitly included among eligible applicants.
Can foreign organizations apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) may apply.
Are foreign components allowed on an NIH application under this FOA?
Yes. Foreign components are allowed under NIH policy, and non-U.S. components of U.S. organizations may participate.
What NIH program areas are associated with this FOA?
The FOA is associated with the following CFDA numbers: 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research).
What do the listed CFDA numbers suggest about the scientific scope?
The mix of CFDA areas signals an interdisciplinary scope spanning behavioral and mental health considerations, clinical and public health prevention science, and infectious disease research.
Does this FOA focus on community-wide prevention efforts?
Yes. A major focus is the growing push by local, state, and federal programs to implement community-wide prevention efforts, and the need for methodological and implementation evidence to support those strategies at scale.
What kinds of practical questions does NIH want research to help answer?
The FOA highlights questions such as: which intervention components matter most, how components interact, what level of coverage is required, how implementation quality affects outcomes, and how to measure success in ways that reflect real community impact.
Where were applicants directed for full instructions?
Applicants were directed to the full announcement on the NIH Grants Guide website for complete instructions.
Who is listed as the contact point for access or linking issues?
The contact point provided is the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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