Opportunity Information: Apply for RFA MH 14 182
Apply for RFA MH 14 182
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methodologies and Formative Work for Combination HIV Prevention Approaches (R34)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on May 2, 2013 and posted on May 2, 2013.
- Applicants must submit their applications by Sep 3, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Special district governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Methodologies and Formative Work for Combination HIV Prevention Approaches (R34) is a National Institutes of Health (NIH) discretionary grant opportunity focused on strengthening the science behind combination HIV prevention. The core idea is that meaningful, sustained reductions in HIV incidence are most likely when multiple prevention elements are used together rather than relying on a single strategy. The announcement reflects how HIV prevention has evolved with newer biomedical tools that have strong behavioral and implementation components, such as Pre-Exposure Prophylaxis (PrEP) and Treatment as Prevention (TasP). As more local, state, and federal initiatives push toward community-wide prevention efforts, this funding call is aimed at helping researchers design, refine, and study how multi-component prevention packages can work in real-world settings.
The opportunity emphasizes that combination prevention is not only about pairing biomedical and behavioral interventions, but also about addressing the broader structural conditions that shape HIV risk and transmission. That includes social, economic, and other contextual factors that influence whether people can access prevention and treatment, start and stay on PrEP or antiretroviral therapy, remain engaged in care, and benefit from supportive services. The FOA highlights that progress depends heavily on treatment uptake and retention in care, and on interventions being implemented at scale across communities for public health impact, not just tested in narrowly controlled environments.
A central challenge the FOA is trying to tackle is that combination interventions are inherently complex. Their effects often depend on “synergies†among multiple parts, such as how outreach connects people to testing, how navigation services improve linkage to care, how adherence support strengthens outcomes for PrEP or HIV treatment, and how structural supports reduce barriers like stigma, housing instability, or transportation gaps. Because these pieces interact, it can be difficult to design an intervention package that is coherent and feasible, implement it consistently across settings, and evaluate which elements are driving outcomes. This grant call is therefore geared toward methodological research (improving study designs, measures, analytic approaches, and evaluation strategies), formative work (developing and refining intervention components, understanding community needs and barriers, testing feasibility and acceptability), and implementation-focused research (learning what it takes to deliver combination prevention effectively in practice, and how to monitor processes and outcomes).
The funding opportunity number is RFA-MH-14-182, and it uses the NIH R34 mechanism, which typically supports planning, development, and early-stage work that can position a team for larger-scale effectiveness or implementation studies later. It falls under CFDA 93.242 (Mental Health Research Grants), reflecting NIH’s interest in behavioral, social, and community-level factors that influence HIV prevention outcomes alongside biomedical advances. The announcement indicates an estimated total funding amount of $1,500,000, with an award ceiling of $225,000, and it does not require cost sharing or matching.
Eligibility is broad and includes many types of U.S. organizations and governments as well as non-U.S. entities. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), city/county/state/tribal governments, public housing authorities, independent school districts, special district governments, and various community- and faith-based organizations. The FOA also explicitly includes historically underserved and capacity-building institution types (such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions). Foreign organizations and foreign components of U.S. organizations are allowed, meaning applicants can propose work in international settings or include non-U.S. partners when scientifically justified.
Key dates in the source information show it was posted on May 2, 2013, with an original and current closing date of September 3, 2013, and an archive date of October 4, 2013. In other words, it is an archived opportunity, but the summary remains useful as a snapshot of NIH priorities and the types of methodological and formative questions NIH sought to fund around combination HIV prevention during that period.
In practical terms, a competitive project under this FOA would likely focus on questions such as how to assemble an optimal package of prevention components for a specific community, how to sequence or integrate services to maximize uptake and retention, what implementation supports are needed for community-wide delivery, how to measure both processes (reach, fidelity, engagement, acceptability) and outcomes (testing uptake, PrEP initiation and adherence, viral suppression, incidence trends), and how to evaluate multi-component interventions when traditional single-intervention study designs are not enough. The overall purpose is to produce actionable methods and evidence that make combination HIV prevention easier to implement well, easier to evaluate rigorously, and more effective when scaled to the community level.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled Methodologies and Formative Work for Combination HIV Prevention Approaches (R34). It focuses on strengthening the science behind combination HIV prevention approaches.
What is the FOA number for this opportunity?
The funding opportunity announcement (FOA) number is RFA-MH-14-182.
What NIH grant mechanism does this opportunity use?
This opportunity uses the NIH R34 mechanism, which typically supports planning, development, and early-stage work designed to position a team for larger-scale effectiveness or implementation studies later.
What is the main purpose of this FOA?
The main purpose is to support methodological research, formative work, and implementation-focused research that make combination HIV prevention easier to design, easier to implement in real-world settings, and easier to evaluate rigorously, with the goal of enabling meaningful and sustained reductions in HIV incidence through multi-component prevention packages.
What does "combination HIV prevention" mean in this announcement?
In this FOA, combination HIV prevention refers to using multiple prevention elements together rather than relying on a single strategy. It explicitly includes biomedical tools with behavioral and implementation components (for example, PrEP and Treatment as Prevention), and it also includes behavioral and structural interventions that address broader conditions shaping HIV risk and transmission.
Why does the FOA emphasize using multiple prevention elements together?
The FOA reflects the idea that sustained reductions in HIV incidence are most likely when prevention efforts combine elements that work together (often through "synergies"), rather than depending on a single intervention. The interaction among components like outreach, testing, linkage to care, navigation, adherence support, and structural supports can be critical to overall impact.
What kinds of biomedical strategies are referenced as part of modern prevention approaches?
The announcement references newer biomedical tools that have strong behavioral and implementation components, including Pre-Exposure Prophylaxis (PrEP) and Treatment as Prevention (TasP).
Does the FOA focus only on biomedical and behavioral interventions?
No. The FOA stresses that combination prevention also includes addressing structural conditions and contextual factors (social, economic, and other barriers) that influence access, uptake, adherence, retention in care, and engagement with supportive services.
What types of structural or contextual issues does the FOA highlight?
The FOA notes that social, economic, and contextual factors can shape whether people can access prevention and treatment services, initiate and remain on PrEP or antiretroviral therapy, stay engaged in care, and benefit from supportive services. It also gives examples of barriers that structural supports might address, such as stigma, housing instability, and transportation gaps.
What key scientific challenge is this FOA trying to address?
A central challenge is that combination interventions are inherently complex. Because multiple components interact, it can be difficult to design a coherent and feasible package, implement it consistently across settings, and evaluate which components (or which combinations) are driving outcomes.
What does the FOA mean by "synergies" among intervention components?
"Synergies" refers to how different components can reinforce each other, such as outreach connecting people to testing, navigation improving linkage to care, adherence support strengthening PrEP or HIV treatment outcomes, and structural supports reducing barriers that would otherwise limit engagement and retention.
What kinds of projects are encouraged under the methodological research focus?
The FOA is geared toward improving the science of studying combination prevention, including advances in study designs, measures, analytic approaches, and evaluation strategies suitable for multi-component prevention packages.
What is meant by "formative work" in this opportunity?
Formative work includes activities like developing and refining intervention components, understanding community needs and barriers, and testing feasibility and acceptability of proposed multi-component prevention packages.
How does the FOA define implementation-focused research in this context?
Implementation-focused research here emphasizes learning what it takes to deliver combination prevention effectively in practice, including identifying implementation supports needed for real-world delivery and establishing ways to monitor processes and outcomes during implementation.
Does the FOA emphasize real-world settings or controlled research environments?
The FOA emphasizes designing and studying how combination prevention packages can work in real-world settings and be delivered at scale for community-wide public health impact, not only tested in narrowly controlled environments.
Why are treatment uptake and retention in care highlighted as important?
The FOA indicates that progress in HIV prevention depends heavily on treatment uptake and retention in care, and on interventions being implemented at scale across communities. These factors affect whether prevention and treatment benefits translate into population-level impact.
What are examples of process measures that a project might track?
The FOA suggests measuring implementation and engagement processes such as reach, fidelity, engagement, and acceptability.
What are examples of outcome measures that a project might track?
The FOA suggests outcomes such as testing uptake, PrEP initiation and adherence, viral suppression, and incidence trends.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.242 (Mental Health Research Grants), reflecting NIH interest in behavioral, social, and community-level factors influencing HIV prevention outcomes alongside biomedical advances.
How much total funding is estimated for this FOA?
The source information indicates an estimated total funding amount of $1,500,000.
What is the award ceiling for individual awards under this FOA?
The award ceiling is listed as $225,000.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governments as well as non-U.S. entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), city/county/state/tribal governments, public housing authorities, independent school districts, special district governments, and various community- and faith-based organizations.
Are historically underserved and capacity-building institutions included in eligible applicant types?
Yes. The FOA explicitly includes institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions.
Are foreign organizations or international components allowed?
Yes. The FOA allows foreign organizations and foreign components of U.S. organizations, meaning applicants may propose work in international settings or include non-U.S. partners when scientifically justified.
What are the key dates listed for this FOA?
The source information lists a posting date of May 2, 2013, an original and current closing date of September 3, 2013, and an archive date of October 4, 2013.
Is this an active funding opportunity?
No. Based on the provided dates and the archive date, it is an archived opportunity. The summary remains useful as a snapshot of NIH priorities and the types of methodological and formative questions NIH sought to fund during that period.
What kinds of research questions would likely be competitive under this FOA?
Examples described in the FOA include: how to assemble an optimal package of prevention components for a specific community; how to sequence or integrate services to maximize uptake and retention; what implementation supports are needed for community-wide delivery; how to measure both processes and outcomes; and how to evaluate multi-component interventions when traditional single-intervention study designs are not sufficient.
What is the overall intended impact of projects funded through this FOA?
The overall intent is to generate actionable methods and evidence that make combination HIV prevention easier to implement well, easier to evaluate rigorously, and more effective when scaled to the community level.
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