Opportunity Information: Apply for RFA AI 10 005
Apply for RFA AI 10 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods for Prevention Packages Program (MP3 II) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Mar 18, 2010 and posted on Mar 18, 2010.
- Applicants must submit their applications by Jul 15, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Methods for Prevention Packages Program (MP3 II) (R01) is a National Institutes of Health (NIH) research grant opportunity aimed at improving how HIV prevention is designed, tested, and ultimately delivered to real-world communities. The program is sponsored primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional support from the National Institute of Mental Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). At its core, the opportunity is about building and refining "prevention packages" for HIV, meaning combination intervention strategies that bring together multiple proven or promising prevention components (for example, behavioral, biomedical, structural, and service-delivery elements) into one coherent approach tailored to a specific population.
The FOA is structured around three connected expectations. First, applicants are expected to devise an optimal HIV prevention package for a clearly defined target population. This emphasis on "optimal" and "specific populations" signals that proposals should not be generic. The package should be intentionally assembled based on the realities of the population being served, including their risk context, barriers to uptake, patterns of healthcare access, and social or behavioral factors that influence prevention. Second, the FOA expects pilot work that demonstrates the prevention package is acceptable to the intended participants and that the proposed study approach is feasible. In practice, this means applicants should plan preliminary testing that can show people will actually consider using the interventions, that recruitment and retention strategies are workable, and that the research procedures fit the setting and population. Third, applicants must design clinical protocols that can later be used to rigorously evaluate the safety and efficacy of the prevention package. Even though this funding supports an R01 research project and includes piloting, the program is strongly oriented toward producing a well-developed, testable protocol that can support future definitive studies or clinical evaluations.
Funding is provided through the NIH Research Project Grant (R01) mechanism, which typically supports substantial, hypothesis-driven research projects with a defined scope of work. NIAID indicated an intention to make awards totaling up to $2.5 million in fiscal year 2011, with an anticipated 4 to 6 funded applications under this announcement. In addition, NIMH planned to commit $500,000 in support of this program, reflecting the importance of behavioral, social, and mental health dimensions in HIV prevention package design. NIAAA also planned to provide up to $500,000 specifically for applications that are strongly focused on alcohol-related studies, which aligns with evidence that alcohol use can influence sexual risk behaviors, adherence to prevention strategies, and engagement with health services. The listed award ceiling is $600,000, indicating an upper limit on the amount that can be requested per award under the announcement terms.
The opportunity is categorized as discretionary grant funding in the health domain, and it aligns with multiple CFDA program areas, including mental health research (93.242), alcohol research programs (93.273), and infectious disease and immunology research (93.855, 93.856). There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal funds as a condition of award. Key dates show the announcement was posted on March 18, 2010, with an original and current closing date of July 15, 2010, and an archive date of August 15, 2010, indicating it is a time-limited funding call from that period.
Eligibility is broad and includes many organization types that commonly conduct health research or community-based intervention studies. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both those with and without 501(c)(3) status, other than institutions of higher education), state governments, tribal governments and tribal organizations (including federally recognized tribal governments and other tribal entities), and for-profit organizations (including small businesses and other for-profit entities). The eligibility language also highlights inclusion of faith-based and community-based organizations, historically underrepresented or mission-specific institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs). Non-U.S. entities (foreign organizations) are also listed as eligible, as are U.S. territories or possessions and eligible federal government agencies. This breadth suggests the FOA is designed to encourage multidisciplinary and multi-setting partnerships, including collaborations between academic researchers, clinical sites, public health agencies, and community organizations that can realistically recruit and engage the target populations for HIV prevention research.
Overall, MP3 II (R01) is best understood as a program that pushes investigators to move beyond single-intervention thinking and instead develop well-justified, population-specific combination prevention strategies. It supports the practical steps needed to get from a conceptual package to something that people will accept and use, and then to a clinical-grade protocol capable of being tested rigorously for safety and efficacy. The official announcement is identified as Funding Opportunity Number RFA-AI-10-005, titled "Methods for Prevention Packages Program (MP3 II) (R01)," and the full solicitation was hosted through the NIH grants guide at the provided link.
Frequently Asked Questions (FAQs)
What is the Methods for Prevention Packages Program (MP3 II) (R01)?
MP3 II is a National Institutes of Health (NIH) research grant opportunity focused on improving how HIV prevention is designed, tested, and ultimately delivered in real-world communities. It emphasizes building and refining "prevention packages," meaning combination strategies that integrate multiple prevention components into a single, coherent approach tailored to a specific population.
What is the official Funding Opportunity Number and title?
The Funding Opportunity Number is RFA-AI-10-005. The title is "Methods for Prevention Packages Program (MP3 II) (R01)."
Which NIH institutes sponsor or support this funding opportunity?
The program is sponsored primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional support from the National Institute of Mental Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main goal of this program?
The main goal is to push HIV prevention research beyond single-intervention approaches by supporting the development of population-specific combination prevention packages, along with pilot work and clinical protocols that can later be used to rigorously evaluate safety and efficacy.
What does NIH mean by an HIV "prevention package" in this program?
In MP3 II, a "prevention package" is a combination intervention strategy that brings together multiple proven or promising HIV prevention components. These components can include behavioral, biomedical, structural, and service-delivery elements, assembled into one cohesive approach designed for a specific target population.
Does this program support generic, one-size-fits-all HIV prevention proposals?
No. The FOA emphasizes an "optimal" package for a clearly defined target population. This signals that applications should be intentionally tailored based on the population's real-world context, including barriers to uptake, healthcare access patterns, risk context, and relevant social or behavioral factors.
What are the three main expectations or required elements described in the FOA?
The FOA is structured around three connected expectations: (1) devise an optimal HIV prevention package for a clearly defined target population, (2) conduct pilot work demonstrating acceptability and feasibility of both the package and the research approach, and (3) design clinical protocols that can later be used to rigorously evaluate the safety and efficacy of the package.
What kind of pilot work is expected under MP3 II?
Pilot work should demonstrate that the prevention package is acceptable to intended participants and that the proposed study approach is feasible. This can include showing that participants would consider using the interventions, that recruitment and retention strategies are workable, and that research procedures fit the setting and population.
Is the program focused only on piloting, or does it also require planning for rigorous evaluation?
It includes piloting, but it is strongly oriented toward producing well-developed, testable clinical protocols that can support later rigorous evaluations of safety and efficacy in definitive studies or clinical evaluations.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports substantial, hypothesis-driven research projects with a defined scope of work.
How much total funding did NIAID intend to award under this announcement?
NIAID indicated an intention to make awards totaling up to $2.5 million in fiscal year 2011 under this announcement.
How many awards were anticipated?
The announcement anticipated funding approximately 4 to 6 applications.
What additional funding support is associated with NIMH?
NIMH planned to commit $500,000 in support of this program, reflecting the role of behavioral, social, and mental health dimensions in HIV prevention package design.
What additional funding support is associated with NIAAA?
NIAAA planned to provide up to $500,000 specifically for applications that are strongly focused on alcohol-related studies.
Why does this FOA highlight alcohol-related studies?
The FOA aligns alcohol-focused projects with evidence that alcohol use can influence sexual risk behaviors, adherence to prevention strategies, and engagement with health services, making it relevant to HIV prevention package development.
Is there an award ceiling for individual awards under this announcement?
Yes. The listed award ceiling is $600,000, indicating an upper limit on the amount that can be requested per award under the announcement terms.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal funds as a condition of the award.
What type of funding is this categorized as?
The opportunity is categorized as discretionary grant funding in the health domain.
Which CFDA program areas are associated with this opportunity?
The FOA aligns with multiple CFDA program areas, including mental health research (93.242), alcohol research programs (93.273), and infectious disease and immunology research (93.855 and 93.856).
When was the announcement posted, and what were the key dates?
The announcement was posted on March 18, 2010. The original and current closing date was July 15, 2010, and the archive date was August 15, 2010.
Is this a current, open opportunity?
Based on the provided dates (closing date July 15, 2010 and archive date August 15, 2010), this was a time-limited funding call from that period.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education); state governments; tribal governments and tribal organizations; for-profit organizations (including small businesses); U.S. territories or possessions; eligible federal government agencies; and non-U.S. entities (foreign organizations).
Are faith-based and community-based organizations eligible?
Yes. The eligibility language explicitly highlights faith-based and community-based organizations.
Are historically underrepresented or mission-specific institutions included in eligibility?
Yes. The eligibility language highlights institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other related entities.
Are foreign organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations) are listed as eligible applicants.
What kinds of partnerships or project settings does this FOA seem to encourage?
The breadth of eligibility suggests the FOA is designed to encourage multidisciplinary and multi-setting partnerships, including collaborations among academic researchers, clinical sites, public health agencies, and community organizations capable of recruiting and engaging the target populations for HIV prevention research.
What should an applicant consider when defining the target population?
The FOA stresses clearly defined, specific populations and expects the prevention package to be built around real-world factors such as the population's risk context, barriers to uptake, patterns of healthcare access, and social or behavioral factors that influence prevention.
Where was the full solicitation hosted?
The full solicitation was hosted through the NIH grants guide at the link referenced in the opportunity description.
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