Opportunity Information: Apply for RFA AG 14 006
Apply for RFA AG 14 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mid life Reversibility of Early established Biobehavioral Risk Factors (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 17, 2013 and posted on Jul 17, 2013.
- Applicants must submit their applications by Feb 3, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments For profit organizations other than small businesses Small businesses Native American tribal governments (Federally recognized) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Mid life Reversibility of Early established Biobehavioral Risk Factors (R01) opportunity (RFA-AG-14-006) was a National Institute on Aging (NIA), National Institutes of Health (NIH) funding announcement focused on a basic but practical question in aging research: to what extent can the long-term biological, behavioral, and psychological effects of early-life disadvantage be changed during midlife. The program’s central idea is that early adversity can shape risk-related systems in ways that persist for decades, but that midlife may still offer meaningful "plasticity" or malleability. By funding projects aimed at understanding and testing that plasticity, NIA sought to speed progress toward intervention strategies that could reduce enduring risk and improve health trajectories as people age.
This was a discretionary grant program using the NIH Research Project Grant (R01) mechanism, with an unusual emphasis on a two-year project period. Applications were expected to investigate biobehavioral or psychological systems that are known (or strongly suspected) to be influenced by early disadvantage and then examine whether those systems can be altered in adulthood, especially in midlife. The announcement encouraged work that goes beyond documenting long-term associations and instead looks for conditions, mechanisms, and leverage points that could make risk persistence reversible or at least reducible. In other words, the goal was not only to explain how early adversity "gets under the skin," but also to identify when and how its downstream effects might be interrupted later in life.
To accelerate intervention development, NIA emphasized two broad, encouraged approaches. One approach was to use existing human cohort data to identify real-world circumstances that either mitigate or exacerbate the long-run effects of early adversity. This could include analyses that reveal protective factors, turning points, or context changes in adulthood that weaken the link between early disadvantage and later outcomes. The other approach was to use human and/or animal models to test the feasibility of interventions aimed specifically at increasing adult malleability in the mechanisms that keep risk in place. That framing makes the projects inherently translational in spirit: even if the work is mechanistic, it is supposed to inform credible strategies for altering trajectories, not just describing them.
In terms of scale and budget, the announcement anticipated about 6 awards, with an estimated total funding level of $1,800,000. The listed award ceiling was $200,000 (as provided in the source data), and there was no cost sharing or matching requirement. The opportunity was posted on July 17, 2013, with an original and current closing date of February 3, 2014, and it was later archived on March 6, 2014. The activity category was health, and the CFDA program number associated with it was 93.866 (Aging Research).
Eligibility was broad and included many common NIH applicant types across academia, nonprofit, government, and industry. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit types), for-profit organizations (other than small businesses as well as small businesses), and a wide range of government entities (state, county, city/township, special district, and independent school districts). The FOA also explicitly included tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a variety of mission-relevant institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander serving institutions (AANAPISIs). Faith-based and community-based organizations were also included. Notably, non-U.S. entities were eligible to apply: foreign organizations and foreign institutions were allowed, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were permitted.
Operationally, the full announcement was hosted through NIH at the link provided in the source data (grants.nih.gov). The contact information included NIH’s Office of Extramural Research (OER) webmaster emails for technical problems accessing or linking to the funding announcement. Overall, this FOA can be read as a targeted, time-limited push by NIA to move the field past the assumption that early-life disadvantage creates irreversible pathways, and toward evidence about whether midlife offers realistic opportunities to disrupt entrenched biobehavioral risk mechanisms before they translate into poorer aging outcomes.
Frequently Asked Questions (FAQs)
What is the Mid life Reversibility of Early established Biobehavioral Risk Factors (R01) funding opportunity?
This opportunity (RFA-AG-14-006) was a National Institute on Aging (NIA), National Institutes of Health (NIH) funding announcement that asked a practical aging-research question: to what extent can the long-term biological, behavioral, and psychological effects of early-life disadvantage be changed during midlife.
Which agency offered this grant?
The funding announcement was offered by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH).
What is the main goal of the program?
The program aimed to move the field beyond documenting long-term associations between early adversity and later outcomes, and toward identifying conditions, mechanisms, and leverage points that could make persistent risk reversible or at least reducible during adulthood, especially midlife.
What does the program mean by "midlife plasticity" or malleability?
The announcement emphasized the idea that while early adversity can shape risk-related systems for decades, midlife may still provide meaningful opportunities for those systems to change. Projects were expected to explore whether adult (midlife) change is possible in the mechanisms that keep early-life risk "in place."
What kinds of research topics were expected to be responsive?
Applications were expected to investigate biobehavioral or psychological systems that are known (or strongly suspected) to be influenced by early disadvantage, and then examine whether those systems can be altered in adulthood, with a particular focus on midlife.
Was this opportunity focused on basic research, applied research, or both?
It was framed as basic but practical and translational in spirit. Even when studies were mechanistic, they were expected to inform credible strategies for altering trajectories, not just describing how early adversity produces long-lasting effects.
What grant mechanism was used?
The funding mechanism was the NIH Research Project Grant (R01).
Was there anything unusual about the project period?
Yes. The announcement had an unusual emphasis on a two-year project period.
How many awards were anticipated?
The announcement anticipated about 6 awards.
What was the estimated total funding level for the program?
The estimated total funding level listed was $1,800,000.
What was the listed award ceiling?
The listed award ceiling was $200,000 (as provided in the source data).
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
What approaches did NIA encourage to speed intervention development?
NIA emphasized two broad, encouraged approaches: (1) using existing human cohort data to identify real-world circumstances that mitigate or exacerbate long-run effects of early adversity (including protective factors, turning points, or adult context changes), and (2) using human and/or animal models to test the feasibility of interventions aimed at increasing adult malleability in the mechanisms that maintain risk.
Could applicants use existing cohort datasets rather than collecting new data?
Yes. One explicitly encouraged approach was analysis of existing human cohort data to identify circumstances that weaken or strengthen the link between early disadvantage and later-life outcomes.
Were animal models allowed under this announcement?
Yes. The announcement encouraged the use of human and/or animal models to test the feasibility of interventions targeting adult malleability in risk-related mechanisms.
What types of outcomes or endpoints were of interest?
The announcement highlighted biological, behavioral, and psychological systems affected by early disadvantage and whether their downstream, long-term effects can be interrupted in adulthood to improve health trajectories as people age.
What was the activity category for this funding announcement?
The activity category was health.
What CFDA number was associated with this program?
The CFDA program number associated with it was 93.866 (Aging Research).
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and other nonprofit types); for-profit organizations (including small businesses and for-profits other than small businesses); and many government entities (state, county, city/township, special district, and independent school districts).
Were tribal governments and tribal organizations eligible?
Yes. The announcement explicitly included tribal governments and tribal organizations.
Were specific institution types (such as minority-serving institutions) included?
Yes. The eligibility language explicitly included mission-relevant institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander serving institutions (AANAPISIs).
Could faith-based and community-based organizations apply?
Yes. Faith-based and community-based organizations were included in the eligible applicant types.
Were non-U.S. (foreign) organizations allowed to apply?
Yes. Non-U.S. entities were eligible: foreign organizations and foreign institutions were allowed, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were permitted.
What were the key dates for this opportunity?
The opportunity was posted on July 17, 2013. The original and current closing date was February 3, 2014. It was archived on March 6, 2014.
Is the funding announcement still open?
No. Based on the listed closing date (February 3, 2014) and the archive date (March 6, 2014), this funding announcement is closed and archived.
Where was the full announcement hosted?
The full announcement was hosted through NIH at the grants.nih.gov link referenced in the source data.
Who could be contacted for technical issues accessing the announcement?
The contact information included NIH Office of Extramural Research (OER) webmaster emails for technical problems accessing or linking to the funding announcement.
How should a project align with the program's intent?
Projects were expected to focus on whether midlife offers realistic opportunities to disrupt entrenched biobehavioral risk mechanisms shaped by early disadvantage, with an emphasis on identifying mechanisms and conditions that could support later-life intervention strategies.
What was the broader rationale for NIA issuing this FOA?
The FOA represented a targeted, time-limited push to speed progress toward interventions that could reduce enduring risk and improve health trajectories as people age, rather than treating early-life disadvantage as producing inevitably irreversible pathways.
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