Opportunity Information: Apply for PAR 12 021

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Midcareer Investigator Award in Mouse Pathobiology and Comprehensive Phenotyping Research (K26)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351 Research Infrastructure Programs 93.389 National Center for Research Resources.
  • This funding opportunity was created on Sep 19, 2012 and posted on Nov 17, 2011.
  • Applicants must submit their applications by Sep 20, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Private institutions of higher education For profit organizations other than small businesses City or township governments Special district governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The Midcareer Investigator Award in Mouse Pathobiology and Comprehensive Phenotyping Research (K26) is an NIH grant opportunity from the National Center for Research Resources (NCRR) designed to support accomplished, midcareer scientists who are already well established in their fields. The central purpose is to buy protected time for these investigators so they can focus more intensely on mouse pathobiology research and the comprehensive phenotyping of genetically modified mice. In practical terms, the award is meant to reduce the day-to-day drain of institutional service work and administrative duties that often accumulate for successful faculty, freeing them to deepen specialized research programs that depend on rigorous mouse-based disease analysis and high-quality, systematic phenotyping.

A key feature of the opportunity is that it is not only about the awardee's research output; it also explicitly emphasizes mentoring. The program aims to position the funded investigator as a resource for junior scientists by creating time and structure for hands-on guidance, training, and scientific leadership in areas related to mouse pathobiology and phenotyping methods. That combination of protected research time plus deliberate mentoring is meant to strengthen research capacity more broadly, not just for a single lab, by improving expertise and standards in how genetically modified mouse models are evaluated and interpreted.

Administratively, this is a discretionary grant program under the NIH umbrella and is categorized under education and health-related funding activities. It is associated with CFDA numbers 93.351 (Research Infrastructure Programs) and 93.389 (National Center for Research Resources), and it does not require cost sharing or matching, which generally lowers the barrier for institutions that might otherwise struggle to commit non-federal funds. The announcement was originally posted on November 17, 2011, with key dates showing it was later archived (archive date October 20, 2012). The source information also lists an original closing date of January 7, 2015, while indicating a current closing date of September 20, 2012, reflecting the timing details captured in the record for PAR-12-021.

Eligibility is broad across many types of U.S.-based organizations, spanning public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities outside of higher education), state and local governments (including counties, cities/townships, and special districts), tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and for-profit organizations (with small businesses listed separately from other for-profits). The eligibility language also explicitly includes a range of mission- or community-focused institutions and groups, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based and community-based organizations, and U.S. territories or possessions, along with eligible federal agencies. At the same time, the announcement clearly excludes non-U.S. entities: foreign institutions cannot apply, non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as referenced in the NIH Grants Policy Statement.

For applicants trying to locate or verify the full text and instructions, the announcement provides an NIH Grants Guide link associated with PAR-12-021. It also lists a support contact pathway through the NIH Office of Extramural Research (OER) Webmaster email for issues accessing the announcement or problems with links, which is a practical detail for applicants encountering technical barriers while reviewing the FOA materials online.

Overall, the K26 opportunity is best understood as a targeted career-support mechanism for proven investigators whose work depends on sophisticated mouse disease characterization and phenotyping. By reducing service and administrative load and formalizing a mentoring expectation, the program aims to amplify both the quality of mouse-model science and the training pipeline for researchers who will rely on these approaches in translational and basic biomedical research.

Frequently Asked Questions (FAQs)

What is the Midcareer Investigator Award in Mouse Pathobiology and Comprehensive Phenotyping Research (K26)?

It is an NIH grant opportunity from the National Center for Research Resources (NCRR) designed to support accomplished, midcareer scientists who are already well established in their fields. The award is focused on mouse pathobiology research and the comprehensive phenotyping of genetically modified mice.

What is the main purpose of this K26 award?

The central purpose is to buy protected time for the funded investigator. In practical terms, it is intended to reduce the day-to-day drain of institutional service work and administrative duties so the investigator can focus more intensely on rigorous mouse-based disease analysis and high-quality, systematic phenotyping.

What kinds of research does this opportunity emphasize?

The opportunity emphasizes mouse pathobiology and comprehensive phenotyping of genetically modified mice. It is aimed at deepening specialized research programs that rely on careful disease characterization in mouse models and systematic phenotyping approaches.

Is this award only about the awardee's research output?

No. In addition to supporting the investigator's research focus, the announcement explicitly emphasizes mentoring. The program is intended to position the funded investigator as a resource for junior scientists through hands-on guidance, training, and scientific leadership in mouse pathobiology and phenotyping-related methods.

How does mentoring fit into this program?

The award is meant to create time and structure for deliberate mentoring. This includes providing guidance and training to junior scientists and contributing scientific leadership related to mouse pathobiology and phenotyping standards and methods.

What is meant by "protected time" in this context?

"Protected time" refers to time carved out from routine faculty obligations, particularly institutional service work and administrative duties that often accumulate for successful faculty. The goal is to free the investigator to concentrate more fully on mouse pathobiology and comprehensive phenotyping research and related mentoring.

Which NIH organization is associated with this funding opportunity?

The opportunity is associated with the National Center for Research Resources (NCRR) under the NIH umbrella.

What type of program is this administratively?

It is described as a discretionary grant program under NIH and categorized under education and health-related funding activities.

Which CFDA numbers are associated with this opportunity?

The opportunity is associated with CFDA 93.351 (Research Infrastructure Programs) and 93.389 (National Center for Research Resources).

Is cost sharing or matching required?

No. The announcement states that cost sharing or matching is not required.

When was this opportunity posted, and is it archived?

The announcement was originally posted on November 17, 2011, and it shows an archive date of October 20, 2012.

What are the listed closing dates, and why are there multiple dates?

The record lists an original closing date of January 7, 2015, while also indicating a current closing date of September 20, 2012. These timing details are presented as part of the record for PAR-12-021.

Which organizations are eligible to apply?

Eligibility is broad across many types of U.S.-based organizations, including public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities outside of higher education), state and local governments (including counties, cities/townships, and special districts), tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and for-profit organizations (with small businesses listed separately from other for-profits). The eligibility language also includes U.S. territories or possessions and eligible federal agencies.

Are specific mission- or community-focused institutions included in eligibility?

Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), and faith-based and community-based organizations.

Are foreign institutions or non-U.S. components allowed to apply?

No. The announcement clearly excludes non-U.S. entities: foreign institutions cannot apply, non-domestic components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as referenced in the NIH Grants Policy Statement.

How can applicants find the full announcement and instructions?

The opportunity provides an NIH Grants Guide link associated with PAR-12-021, which applicants can use to locate or verify the full text and instructions.

Who can applicants contact if they have trouble accessing the announcement or links?

The announcement lists a support contact pathway through the NIH Office of Extramural Research (OER) Webmaster email for issues accessing the announcement or problems with links.

What is the overall goal of this award for the broader research community?

Beyond supporting an individual investigator, the program aims to strengthen research capacity more broadly by improving expertise and standards in how genetically modified mouse models are evaluated and interpreted, while also strengthening the training pipeline through structured mentoring.

What is the opportunity identifier mentioned for this announcement?

The information references PAR-12-021 as the associated announcement identifier.

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