Opportunity Information: Apply for PA 16 206

  • The HHS-NIH11 in the education, environment, food and nutrition, health sector is offering a public funding opportunity titled "Midcareer Investigator Award in Patient-Oriented Research (Parent K24)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.846, 93.847, 93.855, 93.856, 93.866,.
  • This funding opportunity was created on Apr 19, 2016 and posted on Apr 19, 2016.
  • Applicants must submit their applications by Jan 07, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PA 16 206

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Opportunity Summary:

The NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24), funding opportunity number PA-16-206, is a discretionary NIH grant mechanism designed to strengthen the nation s clinical research workforce by investing in established, midcareer clinician scientists. Its central aim is to provide protected time for qualified health-professional doctorate holders (or equivalent clinical doctoral-level professionals) who are typically at the Associate Professor level (or comparable rank) to (1) sustain and expand a focused program of patient-oriented research (POR) and (2) serve as research mentors for the next generation of clinical investigators. In practice, the award is meant to help midcareer clinician researchers balance heavy clinical, administrative, and teaching responsibilities while continuing to produce high-quality, patient-centered science and building a stronger pipeline of trainees who can do the same.

A key feature of the K24 is its explicit dual emphasis on research and mentorship. Recipients are expected not only to pursue their own patient-oriented research agenda, but also to devote substantial effort to mentoring, primarily targeting clinical residents, clinical fellows, and/or junior clinical faculty. The mentorship component is not incidental; it is a core deliverable of the award and is intended to increase the number and quality of clinically trained investigators capable of conducting rigorous research that involves direct interactions with human subjects. This can include studies where an investigator directly engages with patients, uses clinical interventions, collects clinical specimens, or otherwise conducts research in a manner that is tightly linked to human participants and clinical settings.

The opportunity is administered by the U.S. Department of Health and Human Services through the National Institutes of Health (NIH), listed under agency name HHS-NIH11, and spans multiple NIH Institutes and Centers as reflected by the multiple CFDA numbers associated with it (including, for example, 93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.846, 93.847, 93.855, 93.856, and 93.866). Because different NIH components may apply slightly different expectations, allowable costs, salary support levels, or emphasis areas, prospective applicants are encouraged to contact the relevant NIH program staff for institute- or center-specific guidance. The posting specifically points applicants to an NIH table of IC-specific information, requirements, and staff contacts so applicants can confirm fit, budget parameters, and any nuances before submitting an application.

Eligibility is broad at the organizational level. Eligible applicant organizations include various levels of government (state, county, city or township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments (federally recognized) and other Native American tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (outside of higher education institutions), for-profit organizations (other than small businesses), small businesses, and other entities as allowed by NIH policy with additional clarification referenced in the opportunity. While many entity types may be able to apply as the sponsoring institution, the award is fundamentally oriented around supporting an individual midcareer clinician investigator and their environment for patient-oriented research and mentoring, meaning the host institution must be able to credibly provide the infrastructure, patient access, research support, and protected time necessary for the candidate to meet the award s goals.

From a timeline and administrative standpoint, the opportunity was created and posted on April 19, 2016, with an original and current closing date listed as January 7, 2018 in the source data provided. The funding instrument type is a grant, and the activity category is listed under areas including education and health (among others). The record does not specify an award ceiling or the expected number of awards in the provided fields, which is another reason applicants are directed to consult NIH institute-specific details and program contacts for realistic budgeting and competitiveness considerations.

Overall, the Parent K24 is best understood as a career-support and capacity-building award for experienced clinical researchers who are already demonstrating independence and productivity in patient-oriented research, and who are positioned to multiply NIH s investment through sustained mentorship of clinicians in training and early-career faculty. The practical outcome NIH is targeting is a stronger, more stable cadre of clinician investigators who can keep patient-centered research moving forward while training others to do it well, thereby improving the quality and impact of clinical research over time.

Frequently Asked Questions (FAQs): NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24) - PA-16-206

What is the NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24)?

The NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24) is an NIH discretionary grant mechanism intended to strengthen the U.S. clinical research workforce by supporting established, midcareer clinician-scientists. It is designed to provide protected time so recipients can sustain and expand a focused program of patient-oriented research (POR) while also serving as research mentors for the next generation of clinical investigators.

What is the funding opportunity number for this grant?

The funding opportunity number is PA-16-206.

Which federal agency administers this opportunity?

This opportunity is administered by the U.S. Department of Health and Human Services through the National Institutes of Health (NIH), listed under agency name HHS-NIH11.

What is the primary goal of the Parent K24 award?

The central goal is to strengthen the clinical research workforce by investing in midcareer clinician investigators so they can (1) maintain and grow a patient-oriented research program and (2) provide substantial, structured mentorship to clinically trained trainees and early-career faculty.

Who is this award intended for (career stage and background)?

The award is oriented toward established, midcareer clinician-scientists who hold a health-professional doctorate (or equivalent clinical doctoral-level degree). The description indicates candidates are typically at the Associate Professor level (or a comparable rank) and are already positioned to conduct independent patient-oriented research while mentoring others.

What does "patient-oriented research (POR)" mean in this opportunity?

Patient-oriented research, as described here, involves direct interactions with human subjects and clinical settings. Examples include studies where the investigator directly engages with patients, uses clinical interventions, collects clinical specimens, or conducts research closely linked to human participants and clinical care environments.

What are the two main expectations of K24 recipients?

The Parent K24 has a dual emphasis: recipients are expected to (1) sustain and expand their own focused program of patient-oriented research and (2) devote substantial effort to mentoring, especially mentoring clinicians in training and junior clinical faculty.

Is mentorship optional, or is it a required part of the award?

Mentorship is a core deliverable of the award. The opportunity description emphasizes that the mentoring component is not incidental; it is explicitly central to the K24 mechanism.

Who are the primary intended mentees under this award?

The mentoring effort is primarily intended to target clinical residents, clinical fellows, and/or junior clinical faculty.

Why does NIH emphasize protected time for midcareer clinician investigators?

The award is meant to help midcareer clinician researchers balance heavy clinical, administrative, and teaching responsibilities while continuing to produce high-quality patient-centered science and building a stronger pipeline of trainees who can do the same.

Is this opportunity limited to a single NIH Institute or Center?

No. The opportunity spans multiple NIH Institutes and Centers, as reflected by the multiple CFDA numbers associated with it. Because NIH components may vary in expectations or budget details, applicants are directed to consult institute- or center-specific information and contacts.

Why does institute- or center-specific guidance matter for this K24?

The description notes that different NIH Institutes and Centers may apply slightly different expectations, allowable costs, salary support levels, or emphasis areas. Contacting the relevant NIH program staff and reviewing IC-specific information helps applicants confirm fit and understand any nuances before applying.

Where are applicants directed to find IC-specific requirements and contacts?

The posting points applicants to an NIH table that lists institute/center (IC)-specific information, requirements, and staff contacts. This table is intended to help applicants confirm fit, budget parameters, and any institute-specific nuances.

What kinds of organizations are eligible to apply as the sponsoring institution?

Eligible applicant organizations include: state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as allowed by NIH policy (with additional clarification referenced in the opportunity).

If many organizations can apply, what is NIH really funding through the K24?

Although many entity types may serve as the applicant organization, the K24 is fundamentally oriented around supporting an individual midcareer clinician investigator and their environment for patient-oriented research and mentoring. The host institution is expected to be able to provide the infrastructure, patient access, research support, and protected time necessary to meet the award goals.

What type of funding instrument is this opportunity?

The funding instrument type is a grant.

What activity categories are associated with this grant?

The activity category is listed under areas including education and health (among others).

When was this opportunity posted?

The opportunity was created and posted on April 19, 2016.

What is the closing date listed for this opportunity?

The source data provided lists an original and current closing date of January 7, 2018.

Does the provided record list an award ceiling or the expected number of awards?

No. The provided fields do not specify an award ceiling or the expected number of awards. Applicants are encouraged to consult NIH institute-specific details and program contacts for budgeting and competitiveness considerations.

What are the CFDA numbers associated with this opportunity?

The opportunity is associated with multiple CFDA numbers, including: 93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.846, 93.847, 93.855, 93.856, and 93.866.

What practical outcome is NIH trying to achieve through the Parent K24 mechanism?

The intended outcome is a stronger, more stable cadre of clinician investigators who can keep patient-centered research moving forward while training others to do it well, improving the quality and impact of clinical research over time.

What kinds of responsibilities does the K24 help recipients manage?

The award is designed to help recipients maintain research momentum despite heavy clinical, administrative, and teaching responsibilities by providing protected time to conduct patient-oriented research and fulfill mentoring expectations.

Is this opportunity described as a research project grant or a career-support award?

Based on the description, it is best understood as a career-support and capacity-building award aimed at experienced clinical researchers, with a strong expectation of both continued patient-oriented research productivity and sustained mentorship.

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