Opportunity Information: Apply for PA 11 073
Apply for PA 11 073
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 9, 2010 and posted on Dec 9, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Independent school districts Special district governments Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The National Cancer Institute (NCI) at the National Institutes of Health (NIH) released this Funding Opportunity Announcement (FOA) to support Research Project Grant (R01) applications focused on mitochondria and cancer biomarkers. The central aim is to stimulate research that develops and validates new biomarkers that are specifically mitochondrial related, with an emphasis on how those biomarkers can be used in real-world cancer research and clinical or population settings. In practical terms, the opportunity is geared toward projects that can identify measurable mitochondrial signals and then rigorously test whether those signals meaningfully improve cancer early detection, diagnosis, prognosis, risk assessment, or prediction of response to preventive or symptom-improving (ameliorative) interventions.
This announcement targets the full pipeline from discovery through validation, but with a clear tilt toward biomarkers that can stand up to careful evaluation. That includes demonstrating reliability, reproducibility, and relevance to intended use. The mitochondria angle can encompass many biologically grounded avenues, such as mitochondrial DNA (mtDNA) sequence variants or mutations, mtDNA copy number, mitochondrial gene expression signatures, measures tied to oxidative phosphorylation and bioenergetics, reactive oxygen species related damage patterns, mitochondrial metabolites, or other mitochondrial features that can be captured in tissues or accessible biospecimens. The cancer related endpoints are broad and include not only detecting cancer earlier, but also distinguishing disease subtypes, predicting clinical course, estimating risk in individuals or populations, and indicating whether a person is likely to benefit from preventive strategies or treatments intended to reduce harm or improve outcomes.
The award mechanism is the NIH R01, which is intended for independent, hypothesis-driven research projects of substantial scope. The activity categories associated with the FOA span major NCI research areas, including cancer cause and prevention, detection and diagnosis, treatment, biology, and cancer control. There is no cost sharing or matching requirement, meaning applicants are not expected to provide a financial match as a condition of the award.
Eligibility is intentionally broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, as specified), for-profit organizations (including small businesses and other for-profit entities), and various government bodies such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities. The FOA also allows participation from federally recognized tribal governments and other tribal organizations, tribally controlled colleges and universities, and a wide range of mission-focused institutions and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations. Foreign organizations and other non-U.S. entities are listed as eligible, along with U.S. territories or possessions and regional organizations, which reflects NIH interest in encouraging strong science regardless of geography when justified by the research question and resources.
Key administrative details from the posting include the funding opportunity number PA-11-073 and the title "Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01)." It was posted on December 9, 2010, and the original and final closing date listed is January 7, 2014, with an archive date of February 7, 2014. The program is associated with multiple CFDA numbers tied to NCI research domains: 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control). The announcement also provides a standard NIH contact pathway for technical access issues via the NIH Office of Extramural Research (OER) webmaster.
Overall, this FOA is best read as an NCI push to bring mitochondrial biology into the mainstream of cancer biomarker development, with an expectation that proposed markers will be evaluated with the kind of study design and validation rigor needed for meaningful epidemiologic or clinical impact.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a National Cancer Institute (NCI) Funding Opportunity Announcement (FOA) from the National Institutes of Health (NIH) supporting Research Project Grant (R01) applications focused on mitochondria-related cancer biomarkers. The FOA title is "Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01)."
What is the main goal of the FOA?
The central aim is to stimulate research that develops and validates new biomarkers that are specifically mitochondrial related, with an emphasis on how those biomarkers can be used in real-world cancer research and in clinical or population settings.
What kinds of projects are a good fit for this FOA?
Projects that can identify measurable mitochondrial signals and then rigorously test whether those signals meaningfully improve cancer early detection, diagnosis, prognosis, risk assessment, or prediction of response to preventive or symptom-improving (ameliorative) interventions.
Is this FOA focused on discovery, validation, or both?
It targets the full pipeline from discovery through validation, with a clear emphasis on biomarkers that can stand up to careful evaluation, including evidence of reliability, reproducibility, and relevance to the intended use.
What does "mitochondrial related" mean in the context of biomarkers?
The FOA describes multiple biologically grounded avenues for mitochondrial biomarkers, including mitochondrial DNA (mtDNA) sequence variants or mutations, mtDNA copy number, mitochondrial gene expression signatures, measures tied to oxidative phosphorylation and bioenergetics, reactive oxygen species related damage patterns, mitochondrial metabolites, and other mitochondrial features that can be captured in tissues or accessible biospecimens.
What cancer-related outcomes or endpoints are included?
The endpoints are broad and include earlier cancer detection, distinguishing disease subtypes, predicting clinical course (prognosis), estimating risk in individuals or populations, and indicating whether a person is likely to benefit from preventive strategies or interventions intended to reduce harm or improve outcomes.
What award mechanism does this FOA use?
The award mechanism is the NIH Research Project Grant (R01), intended for independent, hypothesis-driven research projects of substantial scope.
Which NCI research areas does the FOA connect to?
The FOA spans major NCI research areas, including cancer cause and prevention, detection and diagnosis, treatment, biology, and cancer control.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not expected to provide a financial match as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status, as specified); for-profit organizations (including small businesses and other for-profit entities); and government bodies such as state, county, city or township, and special district governments, as well as public housing authorities/Indian housing authorities.
Are tribal organizations and tribally controlled institutions eligible?
Yes. The FOA allows participation from federally recognized tribal governments and other tribal organizations, as well as tribally controlled colleges and universities.
Are minority-serving institutions and community-based organizations eligible?
Yes. The eligible applicant types listed include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. Foreign organizations and other non-U.S. entities are listed as eligible. The FOA also lists U.S. territories or possessions and regional organizations as eligible.
What is the FOA number and official title?
The funding opportunity number is PA-11-073, and the title is "Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01)."
When was this FOA posted, and what are the closing dates?
It was posted on December 9, 2010. The original and final closing date listed is January 7, 2014. The archive date is February 7, 2014.
Which CFDA numbers are associated with this opportunity?
The FOA is associated with multiple CFDA numbers tied to NCI research domains: 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control).
What level of rigor is expected for biomarker evaluation?
The FOA emphasizes careful evaluation and validation, including demonstrating reliability, reproducibility, and relevance to how the biomarker is intended to be used in epidemiologic, clinical, or population settings.
What types of samples can be used for mitochondrial biomarker measurements?
The FOA notes that mitochondrial features may be captured in tissues or in accessible biospecimens, as long as the biomarkers are measurable and can be evaluated for meaningful cancer research or clinical/population use.
What should applicants do if they have technical access issues related to the announcement?
The announcement provides a standard NIH contact pathway for technical access issues via the NIH Office of Extramural Research (OER) webmaster.
Browse more opportunities from the same category: Education Health
Next opportunity: Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21)
Previous opportunity: Public Health Research for the Prevention of Complications of Bleeding Disorders
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 11 073
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 11 073) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21) Apply for PA 11 074 Funding Number: PA 11 074 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Cancer Prevention Research Small Grant Program (R03) Apply for PAR 11 079 Funding Number: PAR 11 079 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Shared Instrumentation Grant Program (S10) Apply for PAR 11 081 Funding Number: PAR 11 081 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13) Apply for PAR 11 084 Funding Number: PAR 11 084 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| New Molecular Entities to Treat Substance Use Disorders (R01) Apply for RFA DA 12 001 Funding Number: RFA DA 12 001 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21) Apply for RFA DA 11 012 Funding Number: RFA DA 11 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R01) Apply for RFA NR 11 003 Funding Number: RFA NR 11 003 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21) Apply for RFA NR 11 004 Funding Number: RFA NR 11 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Acute Life Threatening Conditions and Opportunities for Palliative and End of Life Care Research (R01) Apply for RFA NR 11 008 Funding Number: RFA NR 11 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Interdisciplinary Approaches for HIV/AIDS Risk Avoidance Decision Making in Developing Adolescents (R01) Apply for RFA NR 11 007 Funding Number: RFA NR 11 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Alzheimers Disease Pilot Clinical Trials (R01) Apply for PAR 11 100 Funding Number: PAR 11 100 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| U.S. India Bilateral Brain Research Collaborative Partnerships (U.S. India BRCP) (R21) Apply for PAR 11 099 Funding Number: PAR 11 099 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Increasing Opportunities in Advanced Heart Failure and Palliative Care Research (R01) Apply for RFA NR 11 006 Funding Number: RFA NR 11 006 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 11 104 Funding Number: PA 11 104 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 11 105 Funding Number: PA 11 105 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Lasker Clinical Research Scholars Program (SI2) Apply for RFA OD 11 001 Funding Number: RFA OD 11 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Pre Application for the 2011 NIDA Translational Avant Garde Award for Medication Development for Diseases of Addiction (X02) Apply for PAR 11 102 Funding Number: PAR 11 102 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| 2011 NIDA Translational Avant Garde Award for Medication Development for Diseases of Addiction (DP1) Apply for RFA DA 11 009 Funding Number: RFA DA 11 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics, and Prognostics Toward Commercialization (R44) Apply for RFA CA 11 002 Funding Number: RFA CA 11 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| Predictive Animal Models for Smoking Cessation Medications (U54) Apply for RFA DA 11 014 Funding Number: RFA DA 11 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 11 073", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.