Model Systems for Fragile X Pre Mutation and Primary Ovarian Insufficiency (FX POI) (R21) | Apply Online

Opportunity Summary:

The NIH funding opportunity PAR-11-137, titled "Model Systems for Fragile X Pre-Mutation and Primary Ovarian Insufficiency (FX POI) (R21)," is a discretionary grant program designed to push the field forward by improving the research tools available to study fragile X-associated primary ovarian insufficiency. The central aim is to stimulate either the creation of entirely new model systems or the deep, rigorous characterization of ovarian phenotypes in models that already exist but have not yet been fully evaluated for FXPOI-relevant traits. By expanding and refining these models, the FOA seeks to make it possible to answer core biological questions about how the FMR1 repeat expansion affects ovarian function and the trajectory of reproductive aging, ultimately supporting a more solid foundation for evidence-based clinical research in fragile X pre-mutation carriers who are at heightened risk for developing POI.

This opportunity uses the NIH R21 mechanism, which is commonly associated with exploratory and developmental research projects that may be early stage, high impact, or proof-of-concept in nature. The award ceiling listed for this FOA is $200,000, and there is no cost-sharing or matching requirement, which means applicants are not expected to contribute additional non-federal funds as a condition of receiving an award. The program falls under the broad activity category of Health, with CFDA number 93.865, indicating that it is associated with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research portfolio, even though the overall agency listed is the National Institutes of Health.

In practical terms, the FOA is focused on building the kinds of model systems that can reveal mechanisms rather than only describing clinical outcomes. That could include developing animal, cellular, or other experimental models that better mirror the ovarian and reproductive features seen in women who carry the FMR1 pre-mutation, or using existing models and applying more comprehensive reproductive phenotyping to determine whether and how they replicate FXPOI. The underlying logic is that without models that reliably capture the ovarian consequences of the FMR1 repeat expansion, it is difficult to separate correlation from causation, test hypotheses about disease mechanisms, or identify measurable biomarkers and intervention targets that could translate into clinical studies. Stronger models can also help standardize research across labs by providing comparable endpoints for ovarian reserve, follicle dynamics, hormone profiles, fertility measures, and age-related reproductive decline.

Eligibility for this FOA is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants include federal, state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofit organizations both with and without 501(c)(3) status; for-profit organizations other than small businesses as well as small businesses; public housing authorities and Indian housing authorities; and tribal governments and tribal organizations (including those other than federally recognized tribal governments). The eligibility language also explicitly includes several categories that are often highlighted in NIH opportunities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign organizations. In addition, foreign (non-U.S.) components of U.S. organizations are allowed, which can be important for collaborations that rely on specialized expertise, animal resources, or patient-linked biological materials located outside the United States.

Key administrative details from the source record show the FOA was posted and created on March 9, 2011, with an original and current closing date of June 1, 2012, and it was archived on July 2, 2012. The funding instrument type is a grant. The official NIH webpage associated with the announcement is listed as http://grants.nih.gov/grants/guide/pa-files/PAR-11-137.html, and the contact provided for access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

Overall, the opportunity is best understood as a targeted push to close a gap between clinical observations in fragile X pre-mutation carriers and the mechanistic research needed to explain why ovarian function is compromised in a subset of carriers. By encouraging investigators to produce new experimental systems and/or deliver high-quality phenotyping of existing ones, the FOA aims to create a more reliable platform for answering fundamental questions about FMR1-related ovarian biology and for enabling the next step: better designed, evidence-based clinical research for women at risk of FXPOI.

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