Opportunity Information: Apply for RFA GM 11 002
Apply for RFA GM 11 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Modeling of Infectious Disease Agent Systems (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 16, 2010 and posted on Mar 16, 2010.
- Applicants must submit their applications by Jul 15, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity RFA-GM-11-002, titled "Modeling of Infectious Disease Agent Systems (U01)," supports research efforts that strengthen the nation’s ability to anticipate, detect, and reduce the spread of infectious diseases. The main goal is to build better resources, practical tools, and usable scientific knowledge for both the U.S. research community and public health decision-makers, especially in situations involving newly emerging pathogens or the intentional release of harmful biological agents and their products. Projects funded under this announcement are expected to become active members of the Models of Infectious Disease Agent Study (MIDAS) Network, meaning the work is meant to contribute to a larger, coordinated national capability rather than operate as a standalone modeling project.
This program is specifically centered on computational and mathematical modeling of infectious diseases. In practice, that means applicants propose quantitative approaches that can improve understanding of how outbreaks start, how they spread through populations, and what intervention strategies are likely to work under real-world constraints. The emphasis includes threats from naturally occurring outbreaks (like novel influenza strains or other emerging infections) as well as biodefense-relevant scenarios involving deliberate release. Because it is framed as a network effort, the expectation is not only to develop models, but also to generate outputs that are useful to others: shared methods, comparable modeling frameworks, validated simulations, and insights that can help guide preparedness and response planning.
The award mechanism is a Cooperative Agreement (U01), which signals a more collaborative relationship with NIH than a typical research grant. Under a U01, NIH generally anticipates substantial programmatic involvement, such as coordinating activities across the network, setting shared priorities, facilitating data and tool sharing, and aligning individual projects with broader MIDAS objectives. The MIDAS Network itself is described as having multiple parts: a centralized information technology resource, a Centers of Excellence component, and a wider group of multidisciplinary investigators carrying out modeling research. This FOA continues that community of modelers and ties new awards into the existing infrastructure so that results can be integrated, compared, and used quickly when public health needs arise. The announcement is also identified as a reannouncement of an earlier solicitation (RFA-GM-09-001), indicating continuity in program goals and an intent to sustain and expand prior investments.
From a funding and administrative standpoint, the opportunity is listed as discretionary funding under the health-related activity category, with CFDA number 93.859 (Biomedical Research and Research Training). The estimated total funding is $3.5 million, and the award ceiling is $500,000. There is no cost sharing or matching requirement. The posting and creation dates are March 16, 2010, with an original and current closing date of July 15, 2010, and the archive date is August 15, 2010, which places this as a time-limited solicitation from that period.
Eligibility is broad and includes many types of organizations that can contribute modeling expertise and public health impact. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), and small businesses. The eligibility section also explicitly includes a range of institution types and communities, such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and eligible federal agencies. Foreign organizations (non-U.S. entities) are also listed as eligible, which suggests an openness to international modeling expertise and cross-border infectious disease perspectives, provided the application aligns with the U.S.-focused goals of improving national scientific and public health readiness.
Overall, the opportunity is aimed at advancing the science and practical utility of infectious disease modeling in a coordinated, network-based setting. The intended outcome is not only academic advancement, but also stronger national preparedness: models and tools that can support surveillance, forecast outbreak trajectories, test interventions in silico, and help authorities make better-informed choices during fast-moving public health events, whether those events arise naturally or through deliberate biological threats. The full announcement and details are linked through the NIH Grants Guide page provided in the opportunity listing.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH National Institute of General Medical Sciences (NIGMS) funding opportunity announcement (FOA) RFA-GM-11-002 titled "Modeling of Infectious Disease Agent Systems (U01)." It supports research that improves the nation's ability to anticipate, detect, and reduce the spread of infectious diseases through computational and mathematical modeling.
What is the main goal of RFA-GM-11-002?
The main goal is to build better resources, practical tools, and usable scientific knowledge for the U.S. research community and public health decision-makers, particularly for newly emerging pathogens and scenarios involving the intentional release of harmful biological agents and their products.
What types of research does this FOA emphasize?
The program is centered on computational and mathematical modeling of infectious diseases. Applicants are expected to propose quantitative approaches that improve understanding of outbreak emergence, spread through populations, and intervention strategies that work under real-world constraints.
Does this program cover only naturally occurring outbreaks?
No. The scope includes naturally occurring outbreaks (such as novel influenza strains or other emerging infections) and biodefense-relevant scenarios involving deliberate release of harmful biological agents and their products.
What kinds of outputs are expected from funded projects?
Because this is framed as a coordinated network effort, projects are expected to produce outputs that are useful beyond a single research team. Examples described in the opportunity include shared methods, comparable modeling frameworks, validated simulations, and insights that can help guide preparedness and response planning.
Is this a standalone modeling grant, or part of a larger program?
Funded projects are expected to become active members of the Models of Infectious Disease Agent Study (MIDAS) Network. The intent is for each award to contribute to a larger, coordinated national capability rather than operate as a standalone modeling project.
What is the MIDAS Network?
The FOA describes MIDAS as a network with multiple components, including a centralized information technology resource, a Centers of Excellence component, and a wider group of multidisciplinary investigators carrying out modeling research. New awards are tied into this existing infrastructure so results can be integrated, compared, and used quickly when public health needs arise.
What does it mean that the award mechanism is a Cooperative Agreement (U01)?
A Cooperative Agreement (U01) generally indicates a more collaborative relationship with NIH than a typical research grant. Under this mechanism, NIH anticipates substantial programmatic involvement such as coordinating activities across the network, setting shared priorities, facilitating data and tool sharing, and aligning individual projects with broader MIDAS objectives.
How much funding is available under this opportunity?
The estimated total funding is $3.5 million, and the award ceiling is $500,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What is the CFDA number and program category for this FOA?
The CFDA number is 93.859 (Biomedical Research and Research Training). The opportunity is listed as discretionary funding under a health-related activity category.
Who is eligible to apply?
Eligibility is broad and includes: public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), and small businesses. The eligibility section also explicitly includes HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, eligible federal agencies, and foreign organizations (non-U.S. entities).
Are foreign (non-U.S.) organizations allowed to apply?
Yes. Foreign organizations are listed as eligible applicants, indicating openness to international modeling expertise and cross-border infectious disease perspectives, so long as the application aligns with the U.S.-focused goals described in the opportunity.
Is this FOA new or related to an earlier solicitation?
This FOA is described as a reannouncement of an earlier solicitation (RFA-GM-09-001), indicating continuity in program goals and an intent to sustain and expand prior investments.
What are the key dates for this opportunity?
The posting and creation dates are March 16, 2010. The original and current closing date is July 15, 2010. The archive date is August 15, 2010.
Where can applicants find the full announcement?
The opportunity indicates that the full announcement and details are available through the NIH Grants Guide page linked in the opportunity listing.
What is the practical public health impact this program is aiming for?
The stated intent is to strengthen national preparedness by supporting models and tools that can support surveillance, forecast outbreak trajectories, test interventions in silico, and help authorities make better-informed choices during fast-moving public health events.
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