Opportunity Information: Apply for PAR 14 309
Apply for PAR 14 309
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Aug 4, 2014 and posted on Aug 4, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Small businesses Special district governments State governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Molecular and Cellular Substrates of Complex Brain Disorders (R01) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PAR-14-309; CFDA 93.242, Mental Health Research Grants) that supported research aimed at understanding how changes tied to complex brain disorders affect the core cellular and molecular machinery that enables neurons to function. The central emphasis of the announcement is discovery-oriented, mechanistic work: applicants were encouraged to connect disorder-associated alterations (for example, genetic risk factors, molecular pathway disruptions, or other disease-linked changes) to basic neuronal processes at the molecular and cellular level, with the goal of clarifying how such alterations translate into dysfunctional neural function relevant to brain disorders.
The FOA used the R01 mechanism, meaning it was intended for substantial, hypothesis-driven research projects with clear aims, rigorous experimental plans, and the potential to advance fundamental understanding of disease-related neurobiology. The activity category was Health, and the funding instrument type was a Grant. Cost sharing or matching was not required, which is typical for many NIH research project grants and lowers barriers for applicants who might not have access to non-federal matching funds.
Eligibility was broad and included a wide range of U.S. and non-U.S. applicant organizations. Domestic eligible applicants included public and private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), for-profit organizations (including small businesses), state and local governments (including county and city/township governments), independent school districts, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly recognized a wide set of mission-focused and community-rooted institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and eligible federal agencies. Importantly, the announcement allowed foreign participation: non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were permitted, enabling international teams or globally distributed projects to compete where appropriate.
Key administrative details reflect that this was a time-limited opportunity that has since closed. The FOA was posted and created on August 4, 2014, with an original and current closing date of September 7, 2017, and it was archived on October 8, 2017. The sponsoring agency was NIH, and the full announcement was hosted through the NIH Grants Guide (link provided in the source data).
For support with accessing the announcement or resolving link issues, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the "Molecular and Cellular Substrates of Complex Brain Disorders (R01)" funding opportunity?
It is an NIH discretionary grant opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R01)." Its Funding Opportunity Number (FOA number) is PAR-14-309, and it is associated with CFDA 93.242 (Mental Health Research Grants).
Which federal agency sponsored this opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What type of funding mechanism did this FOA use?
This opportunity used the NIH R01 mechanism, which is a research project grant designed for substantial, hypothesis-driven projects with defined aims and rigorous experimental plans.
What was the main scientific purpose of this FOA?
The FOA supported discovery-oriented, mechanistic research aimed at understanding how changes associated with complex brain disorders affect the cellular and molecular machinery that enables neurons to function.
What kind of research emphasis did the announcement prioritize?
The central emphasis was on discovery-oriented mechanistic work. Applicants were encouraged to link disorder-associated alterations to core neuronal processes at the molecular and cellular level to clarify how those alterations lead to dysfunctional neural function relevant to brain disorders.
What types of disorder-associated alterations were mentioned as examples?
Examples included genetic risk factors, disruptions in molecular pathways, and other disease-linked changes associated with complex brain disorders.
What is the expected connection between disorder biology and neuronal function under this FOA?
The FOA encouraged applicants to connect disease-linked alterations to basic neuronal processes at the molecular and cellular level, with the goal of explaining how those changes translate into dysfunctional neural function relevant to brain disorders.
What was the activity category and funding instrument type?
The activity category was Health, and the funding instrument type was a Grant.
Was cost sharing or matching required?
No. Cost sharing or matching was not required.
Who was eligible to apply (in general terms)?
Eligibility was broad and included many U.S. and non-U.S. applicant organizations, including academic, nonprofit, for-profit, government, and other eligible entities described in the announcement.
Which U.S. organizations were eligible to apply?
Domestic eligible applicants included public and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (including small businesses); and various governmental entities such as state and local governments (including county and city/township governments), independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Were small businesses eligible under this FOA?
Yes. For-profit organizations, including small businesses, were included in the eligibility list.
Were nonprofit organizations required to have 501(c)(3) status to be eligible?
No. The FOA listed nonprofits with or without 501(c)(3) status (other than institutions of higher education) as eligible.
Were state and local government entities eligible?
Yes. The eligibility list included state and local governments, including county and city/township governments.
Were education-related public entities like independent school districts eligible?
Yes. Independent school districts were explicitly included as eligible applicants.
Were special district governments eligible?
Yes. Special district governments were included in the list of eligible domestic applicants.
Were public housing authorities eligible to apply?
Yes. Public housing authorities/Indian housing authorities were included as eligible applicants.
Did the FOA explicitly encourage or recognize applications from mission-focused or community-rooted institutions?
Yes. The announcement explicitly recognized a wide set of mission-focused and community-rooted institutions, including HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations.
Were Historically Black Colleges and Universities (HBCUs) included as eligible applicants?
Yes. HBCUs were explicitly listed among the institutions recognized in the FOA.
Were Hispanic-Serving Institutions included?
Yes. Hispanic-Serving Institutions were explicitly listed.
Were Tribally Controlled Colleges and Universities (TCCUs) included?
Yes. TCCUs were explicitly listed.
Were Alaska Native and Native Hawaiian Serving Institutions included?
Yes. Alaska Native and Native Hawaiian Serving Institutions were explicitly listed.
Were AANAPISIs included?
Yes. Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs) were explicitly listed.
Were faith-based and community-based organizations eligible?
Yes. The FOA explicitly recognized faith-based and community-based organizations among eligible applicants.
Were eligible federal agencies included as potential applicants?
Yes. The FOA referenced eligible federal agencies as part of the eligible applicant universe.
Could non-U.S. organizations apply directly?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply.
Could non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations were eligible.
Were foreign components allowed under NIH policy?
Yes. Foreign components (as defined by NIH policy) were permitted.
Is this FOA still open for applications?
No. This was a time-limited opportunity that has since closed.
What were the key dates for this opportunity?
The FOA was posted and created on August 4, 2014. The original and current closing date was September 7, 2017. It was archived on October 8, 2017.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide (via a link provided in the source data).
Who should be contacted for help accessing the announcement or resolving link issues?
The contact listed for support was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What does the R01 mechanism imply about the expected scope of work?
Based on the FOA description, the R01 mechanism implies substantial, hypothesis-driven research with clear aims and rigorous experimental plans, intended to advance fundamental understanding of disease-related neurobiology.
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