Opportunity Information: Apply for PAR 14 310
Apply for PAR 14 310
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Aug 4, 2014 and posted on Aug 4, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments For profit organizations other than small businesses Small businesses Native American tribal governments (Federally recognized) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)" (Funding Opportunity Number PAR 14 310) was a discretionary grant program in the health area (CFDA 93.242, Mental Health Research Grants). It used the NIH R21 mechanism, which is specifically designed to support exploratory and developmental research. In practical terms, this meant the announcement was aimed at early-stage, high-potential projects that are still in the conceptual or proof-of-principle phase, where investigators are testing new ideas, generating preliminary data, or trying out novel approaches that could later be expanded into larger, more definitive studies.
The core scientific goal of the announcement was to stimulate research that clarifies how alterations linked to complex brain disorders affect the basic cellular and molecular foundations of neuronal function. Rather than focusing only on clinical symptoms or broad behavioral outcomes, the emphasis was on uncovering mechanisms at the level of neurons and their supporting biology, such as molecular pathways, cellular processes, and the substrates that underlie how neurons function, communicate, adapt, and survive. The intent was to encourage projects that connect disorder-associated changes (for example, genetic variation, molecular dysregulation, or other biological alterations implicated in complex brain disorders) to concrete impacts on neuronal biology, thereby improving understanding of disease mechanisms and potentially pointing toward new therapeutic strategies or biological targets.
Administratively, the opportunity did not require cost sharing or matching. It was posted on August 4, 2014, with an original closing date of September 7, 2017, and a final closing date of September 7, 2017. The archive date was October 8, 2017, indicating the announcement is no longer active for new submissions under that specific FOA.
Eligibility was intentionally broad and included many types of domestic applicants, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profits that are not small businesses), and multiple levels of government (state, county, city or township, special district governments, and independent school districts). It also included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), as well as public housing authorities and Indian housing authorities. Beyond these categories, the announcement explicitly stated that additional eligible applicants included institutions serving specific populations (such as Historically Black Colleges and Universities, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Notably, non-U.S. entities were also eligible: foreign organizations and foreign institutions could apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed, reflecting NIH's openness to strong neuroscience research capacity wherever it resides.
The sponsoring agency was NIH, and the official announcement page was provided through the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PAR-14-310.html). For access or technical issues related to the online announcement, the contact listed was the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity was titled "Molecular and Cellular Substrates of Complex Brain Disorders (R21)".
What is the Funding Opportunity Number (FOA)?
The Funding Opportunity Number was PAR 14 310.
Which agency sponsored this grant opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What type of grant mechanism did this opportunity use?
This opportunity used the NIH R21 mechanism, which is designed to support exploratory and developmental research.
What kinds of projects was the R21 mechanism intended to support under this announcement?
The announcement was aimed at early-stage, high-potential projects in a conceptual or proof-of-principle phase. This includes work focused on testing new ideas, generating preliminary data, and trying novel approaches that could later be expanded into larger studies.
What was the main scientific goal of this funding opportunity?
The main goal was to stimulate research that clarifies how alterations linked to complex brain disorders affect the basic molecular and cellular foundations of neuronal function.
Was the focus primarily clinical or mechanistic?
The emphasis was on mechanisms at the level of neurons and their supporting biology (molecular pathways, cellular processes, and related substrates), rather than focusing only on clinical symptoms or broad behavioral outcomes.
What types of biological changes was this FOA interested in linking to neuronal function?
The announcement sought projects connecting disorder-associated changes (for example, genetic variation, molecular dysregulation, or other biological alterations implicated in complex brain disorders) to concrete impacts on neuronal biology.
What was the intended impact of the research encouraged by this opportunity?
The intent was to improve understanding of disease mechanisms and potentially point toward new therapeutic strategies or biological targets by tying disorder-linked alterations to neuronal function, communication, adaptation, and survival.
What program area and CFDA number were associated with this opportunity?
This was a discretionary grant program in the health area under CFDA 93.242, Mental Health Research Grants.
Did this funding opportunity require cost sharing or matching?
No. The opportunity did not require cost sharing or matching.
When was the opportunity posted?
It was posted on August 4, 2014.
What was the original closing date?
The original closing date was September 7, 2017.
What was the final closing date?
The final closing date was September 7, 2017.
Is this FOA still active for new submissions?
No. The archive date was October 8, 2017, which indicates the announcement is no longer active for new submissions under that specific FOA.
Who was eligible to apply (in general terms)?
Eligibility was broad and included many types of domestic applicants (higher education institutions, nonprofits, for-profits, and various levels of government) as well as non-U.S. entities (foreign organizations and institutions, non-U.S. components of U.S. organizations, and foreign components as defined by NIH policy).
Are public and state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education were eligible.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education were eligible.
Are nonprofit organizations eligible?
Yes. Eligibility included nonprofit organizations, including both 501(c)(3) and non-501(c)(3) nonprofits.
Are for-profit organizations eligible?
Yes. Eligibility included for-profit organizations, including small businesses and other for-profits that are not small businesses.
Which levels of U.S. government were eligible to apply?
Eligibility included state governments and multiple local government types, including county, city or township, special district governments, and independent school districts.
Are Native American tribal governments and tribal organizations eligible?
Yes. Eligibility included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments).
Are public housing authorities eligible?
Yes. Eligibility included public housing authorities and Indian housing authorities.
Were organizations serving specific populations explicitly included as eligible applicants?
Yes. The FOA explicitly included institutions serving specific populations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions.
Were faith-based or community-based organizations eligible?
Yes. The announcement explicitly stated that faith-based or community-based organizations were eligible.
Were federal agencies eligible to apply?
Yes. The FOA stated that eligible federal agencies could apply.
Were regional organizations eligible?
Yes. Regional organizations were included among eligible applicants.
Were U.S. territories or possessions eligible?
Yes. The FOA explicitly included U.S. territories or possessions.
Were foreign organizations and foreign institutions eligible to apply?
Yes. The announcement stated that foreign organizations and foreign institutions could apply.
Were non-U.S. components of U.S. organizations eligible?
Yes. Non-U.S. components of U.S. organizations were eligible.
Were foreign components allowed under NIH policy?
Yes. The FOA allowed foreign components (as defined by NIH policy).
Where can I find the official NIH Grants Guide announcement page?
The official announcement page was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-310.html
Who should be contacted for access or technical issues with the online announcement?
For access or technical issues, the listed contact was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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