Opportunity Information: Apply for RFA HL 14 009
Apply for RFA HL 14 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Atlas of Lung Development Data Coordinating Center (DCC ) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Mar 12, 2013 and posted on Mar 12, 2013.
- Applicants must submit their applications by Jun 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education City or township governments Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Molecular Atlas of Lung Development Data Coordinating Center (DCC) (U01) opportunity (Funding Opportunity Number RFA-HL-14-009) was a National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) solicitation for a single award to stand up and operate the central informatics and coordination hub for the LungMAP program. LungMAPs broad scientific aim is to create an open-access reference resource: a comprehensive molecular atlas of late-stage lung development in both human and mouse. The intent is that the resulting data, tools, and reagents become widely available to the broader research community, serving as a foundational map that investigators can use to study normal lung development as well as mechanisms relevant to pediatric and adult lung disease.
At the core of the program is the idea of integrating many kinds of molecular information with precise anatomical context. The atlas is meant to combine gene and protein expression data, transcriptomic profiles, epigenomic characterization, and other molecular measurements, and align those with high-resolution anatomical information. This integration is designed to produce molecular profiles for cell types that are defined by function and/or anatomy within the developing lung. In practical terms, the program envisions being able to describe which genes, proteins, and regulatory features are present in specific lung cell populations at late developmental stages, and to link those signatures to where those cells reside in lung structures and how those structures are forming.
The DCC role is central and operational rather than purely hypothesis-driven. Under the cooperative agreement (U01) mechanism, the awardee would be expected to handle the end-to-end data pipeline for the consortium: collecting data generated across LungMAP sites, performing data quality checks and standardization, integrating heterogeneous datasets, and supporting downstream analyses that make the atlas coherent and usable. Just as importantly, the DCC is responsible for developing, hosting, and maintaining the LungMAP database and associated website so that the atlas is accessible as an open resource. That includes building infrastructure for data submission, curation, storage, search, visualization, and dissemination, with an emphasis on usability for external researchers who were not part of the original consortium. In addition to data responsibilities, the DCC is tasked with coordinating research activities across participating components, specifically the Human Tissue Core (HTC) and the Research Centers (RCs), which implies consortium-level project management functions such as facilitating communication, harmonizing procedures, tracking milestones, and supporting shared standards and timelines.
Administratively, this was a discretionary funding opportunity using a cooperative agreement instrument, indicating substantial NHLBI program involvement and an expectation of active coordination between the NIH and the awardee. The activity category is health, and the CFDA number listed is 93.838 (Lung Diseases Research). The opportunity anticipated one award with an estimated total funding level of $7,300,000. Cost sharing or matching was not required. The announcement was posted and created on March 12, 2013, with an original and current closing date of June 19, 2013, and an archive date of July 20, 2013.
Eligibility was broad across U.S.-based organizations, spanning public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), and many government entities (state, county, city or township, special district, independent school districts, and public/Indian housing authorities). Additional eligible applicant categories explicitly included several institution types and community-focused entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions were not eligible to apply, and non-U.S. components of U.S. organizations were not eligible. Foreign components, as defined by NIH policy, were not allowed.
Overall, this opportunity was designed to fund a single, highly capable coordinating center that could unify complex, multi-site biological and imaging datasets into a standardized, high-quality, well-documented atlas of late-stage lung development. The emphasis on open access, rigorous integration of molecular and anatomical data, and centralized coordination reflects the goal of producing a durable community resource rather than a standalone research project. For full details, the announcement pointed applicants to the NIH Grants Guide page for RFA-HL-14-009.
Frequently Asked Questions (FAQs)
What is the Molecular Atlas of Lung Development Data Coordinating Center (DCC) (U01) opportunity?
It is a National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) funding opportunity (Funding Opportunity Number RFA-HL-14-009) to support a single awardee that would stand up and operate the central informatics and coordination hub for the LungMAP program.
What is the main goal of the LungMAP program?
LungMAP aims to create an open-access reference resource: a comprehensive molecular atlas of late-stage lung development in both human and mouse. The intent is for the data, tools, and reagents to be widely available to the broader research community.
What is meant by a "molecular atlas" in this program?
The atlas is intended to integrate multiple kinds of molecular information (for example, gene and protein expression data, transcriptomic profiles, and epigenomic characterization) with precise anatomical context. The goal is to produce molecular profiles for lung cell types defined by function and/or anatomy within the developing lung.
Why is anatomical context important for the LungMAP atlas?
The program emphasizes aligning molecular measurements with high-resolution anatomical information so that researchers can connect molecular signatures to where specific cell populations reside in lung structures and how those structures are forming during late-stage development.
What kinds of data does LungMAP expect to integrate?
Based on the opportunity description, the atlas is meant to combine gene and protein expression data, transcriptomic profiles, epigenomic characterization, and other molecular measurements, and align them with high-resolution anatomical information.
What is the primary role of the Data Coordinating Center (DCC)?
The DCC role is central and operational rather than purely hypothesis-driven. The awardee is expected to manage the end-to-end data pipeline for the consortium and serve as the central informatics and coordination hub for LungMAP.
What does "end-to-end data pipeline" mean for this DCC award?
It includes collecting data generated across LungMAP sites, performing data quality checks and standardization, integrating heterogeneous datasets, and supporting downstream analyses so the atlas is coherent and usable.
What open-access responsibilities does the DCC have?
The DCC is responsible for developing, hosting, and maintaining the LungMAP database and associated website so that the atlas is accessible as an open resource to the research community.
What website and database capabilities are expected from the DCC?
The DCC is expected to build infrastructure for data submission, curation, storage, search, visualization, and dissemination, with an emphasis on usability for external researchers who were not part of the original consortium.
Is the DCC expected to do consortium coordination in addition to data management?
Yes. The DCC is also tasked with coordinating research activities across participating components, specifically the Human Tissue Core (HTC) and the Research Centers (RCs). This implies consortium-level project management such as facilitating communication, harmonizing procedures, tracking milestones, and supporting shared standards and timelines.
What funding mechanism is used for this opportunity?
This opportunity uses a cooperative agreement (U01) mechanism, which indicates substantial NHLBI program involvement and active coordination between NIH and the awardee.
How many awards were anticipated?
The opportunity anticipated one award.
What was the estimated total funding level?
The estimated total funding level was $7,300,000.
Is cost sharing or matching required?
No. Cost sharing or matching was not required.
What is the activity category and CFDA number for this opportunity?
The activity category is health, and the CFDA number listed is 93.838 (Lung Diseases Research).
Who was the sponsoring agency?
The sponsoring agency was the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI).
When was the announcement posted and when did it close?
The announcement was posted/created on March 12, 2013. The original and current closing date was June 19, 2013. The archive date was July 20, 2013.
What types of U.S. organizations were eligible to apply?
Eligibility was broad across U.S.-based organizations, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), and many government entities (state, county, city or township, special district, independent school districts, and public/Indian housing authorities).
Were minority-serving institutions and community-focused entities eligible?
Yes. The opportunity explicitly included eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions. It also referenced faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions as eligible categories.
Are foreign institutions eligible to apply?
No. Foreign institutions were not eligible to apply.
Can a U.S. organization apply if it includes a non-U.S. component?
No. Non-U.S. components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed.
What is the intended impact of making LungMAP data and tools open-access?
The intent is for the resource to serve as a foundational map that investigators can use to study normal lung development and mechanisms relevant to pediatric and adult lung disease, with broad availability to researchers beyond the original consortium.
Is this opportunity focused on creating a durable community resource or a standalone research project?
The opportunity emphasizes producing a durable, open-access community resource. The DCC is expected to unify complex multi-site datasets into a standardized, high-quality, well-documented atlas rather than pursuing a purely hypothesis-driven standalone project.
Where were applicants directed for full details about the solicitation?
Applicants were directed to the NIH Grants Guide page for RFA-HL-14-009 for full details.
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