Opportunity Information: Apply for RFA HL 14 007
Apply for RFA HL 14 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Atlas of Lung Development Human Tissue Core (HTC)(U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Mar 12, 2013 and posted on Mar 12, 2013.
- Applicants must submit their applications by Jun 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,800,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal governments (Federally recognized) Private institutions of higher education State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Molecular Atlas of Lung Development Human Tissue Core (HTC) (U01) funding opportunity (RFA-HL-14-007) was issued by the National Institutes of Health (NIH), specifically the National Heart, Lung, and Blood Institute (NHLBI), to support a central “human tissue core†for the LungMAP program. LungMAP is a large, coordinated effort aimed at building an open-access reference resource that maps the molecular and cellular landscape of the late-stage developing lung in both humans and mice. The intent is to produce a comprehensive atlas that the broader research community can use, with both the underlying datasets and associated reagents made broadly available rather than kept within a single consortium.
Scientifically, the opportunity is designed around integrating multiple layers of biological information to define and characterize developing lung cell types with high precision. The atlas is expected to combine gene and protein expression patterns with deeper molecular profiling such as transcriptomic and epigenomic characterization, alongside other molecular measurements as they become relevant. A key feature is that these molecular profiles are meant to be anchored to high-resolution anatomical context, so that researchers can connect molecular signatures to specific structures, regions, and functionally or anatomically defined cell populations within the developing lung. In practical terms, this kind of integrated atlas is meant to serve as a reference baseline for developmental biology and for understanding how disruptions in normal development may contribute to pediatric and lifelong lung disease.
The Human Tissue Core is the operational backbone for the human sample side of that vision. Rather than primarily performing discovery experiments itself, the HTC’s central responsibility is to ensure that high-quality, well-annotated human lung tissue specimens are consistently identified, collected, processed, stored or deposited as appropriate, and then distributed to LungMAP Research Centers (RCs) that carry out the molecular assays and analyses. To do this, the HTC is expected to identify and manage tissue source sites, coordinate acquisition logistics, and implement standardized workflows so that samples sent to different RCs remain comparable. The overall emphasis is on reliable, ethical, and reproducible handling of human specimens, because the quality and consistency of tissue acquisition and processing directly determines the usefulness of the downstream molecular atlas.
From a grants and administration standpoint, this announcement used the cooperative agreement mechanism (U01), which typically means the project is carried out with substantial involvement from the NIH program staff compared with a standard research project grant. The opportunity fell under the “Health†activity category and was associated with CFDA number 93.838 (Lung Diseases Research). It did not require cost sharing or matching. The announcement was posted and created on March 12, 2013, with an original and current closing date of June 19, 2013, and it was archived on July 20, 2013. The estimated total funding amount listed for the opportunity was $6,800,000.
Eligibility was broad across U.S.-based organizational types, reflecting the infrastructure-heavy nature of a tissue core. Eligible applicants included a wide range of government entities (state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities), higher education institutions (public and state controlled institutions of higher education and private institutions of higher education), nonprofit organizations (both 501(c)(3) and non-501(c)(3) nonprofits), and for-profit organizations (including small businesses and other for-profit entities). The eligibility section also explicitly noted additional categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American and Native American Pacific Islander serving institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions and non-U.S. organizational components were not eligible to apply, although foreign components as defined by NIH policy were allowed.
Overall, the opportunity is best understood as funding a specialized, centrally coordinated resource that enables the rest of the LungMAP consortium to function. By building and managing the pipeline for human developing lung tissue from source sites to processing to distribution, the HTC supports the creation of a standardized, high-quality specimen foundation for the multi-omic, anatomically resolved molecular atlas that LungMAP aims to provide to the entire biomedical research community.
For full details, NIH pointed applicants to the official RFA page (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-14-007.html) and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
FAQs: Molecular Atlas of Lung Development Human Tissue Core (HTC) (U01) - RFA-HL-14-007
What is this funding opportunity?
This opportunity is the Molecular Atlas of Lung Development Human Tissue Core (HTC) (U01) funding opportunity, identified as RFA-HL-14-007. It was issued by the National Institutes of Health (NIH), specifically the National Heart, Lung, and Blood Institute (NHLBI), to support a central human tissue core for the LungMAP program.
Which NIH institute is sponsoring the opportunity?
The opportunity was issued by NIH through the National Heart, Lung, and Blood Institute (NHLBI).
What program is this opportunity supporting?
It supports LungMAP, a large coordinated effort to build an open-access reference resource mapping the molecular and cellular landscape of the late-stage developing lung in humans and mice.
What is the main goal of LungMAP?
The goal is to create a comprehensive atlas of the developing lung that integrates molecular and cellular information, and to make the resulting datasets and associated reagents broadly available to the wider research community (not kept within a single consortium).
What does "open-access reference resource" mean in this context?
It means the atlas is intended to be broadly usable by the research community, with underlying datasets and associated reagents made widely available rather than restricted to only the participating consortium.
What kinds of scientific data are expected to be integrated into the atlas?
The atlas is expected to integrate multiple layers of biological information, including gene and protein expression patterns, transcriptomic and epigenomic characterization, and other molecular measurements as they become relevant.
Why is anatomical context emphasized for the atlas?
A key feature is anchoring molecular profiles to high-resolution anatomical context so researchers can connect molecular signatures to specific structures, regions, and functionally or anatomically defined cell populations in the developing lung.
How is this atlas expected to be used by the research community?
It is intended to serve as a reference baseline for developmental biology and for understanding how disruptions in normal lung development may contribute to pediatric and lifelong lung disease.
What is the Human Tissue Core (HTC)?
The HTC is the central operational resource for the human sample side of LungMAP. Its role is to ensure high-quality, well-annotated human lung tissue specimens are identified, collected, processed, stored or deposited as appropriate, and distributed to LungMAP Research Centers (RCs).
Is the HTC mainly responsible for discovery experiments?
No. The HTC is described as the operational backbone for acquiring and handling human tissue specimens, while LungMAP Research Centers (RCs) carry out the molecular assays and analyses.
What are the core responsibilities of the HTC?
The HTC is expected to: identify and manage tissue source sites; coordinate acquisition logistics; implement standardized workflows; ensure consistent identification, collection, processing, and handling; store or deposit specimens as appropriate; and distribute specimens to LungMAP Research Centers so samples remain comparable across sites and studies.
Why are standardized workflows important for this tissue core?
Standardized workflows help ensure that samples sent to different Research Centers remain comparable, which is critical for building a consistent and useful molecular atlas.
What is the emphasis regarding human specimens?
The emphasis is on reliable, ethical, and reproducible handling of human specimens, because tissue acquisition and processing quality and consistency directly affect the value of downstream molecular atlas data.
What funding mechanism is used for this opportunity?
The announcement used the cooperative agreement mechanism (U01), which typically involves substantial involvement from NIH program staff compared with a standard research project grant.
What does a U01 cooperative agreement imply about NIH involvement?
It generally implies more substantial involvement from NIH program staff in the project compared with standard grant mechanisms, consistent with the coordinated, infrastructure-focused nature of a central tissue core.
What is the activity category associated with this opportunity?
The opportunity fell under the "Health" activity category.
What is the CFDA number for this opportunity?
The opportunity is associated with CFDA number 93.838 (Lung Diseases Research).
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching was not required.
What is the estimated total funding amount listed?
The estimated total funding amount listed for the opportunity was $6,800,000.
When was the opportunity posted?
The announcement was posted and created on March 12, 2013.
What was the closing date for applications?
The original and current closing date listed was June 19, 2013.
Is this opportunity still open?
No. It was archived on July 20, 2013, and the closing date listed was June 19, 2013.
Who is eligible to apply?
Eligibility was broad across U.S.-based organizational types. Eligible applicants included various government entities, higher education institutions (public and private), nonprofit organizations (501(c)(3) and non-501(c)(3)), and for-profit organizations (including small businesses and other for-profit entities).
Which government entities are listed as eligible?
Eligible government entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are universities and colleges eligible?
Yes. Eligible higher education institutions included public and state controlled institutions of higher education and private institutions of higher education.
Are nonprofits eligible?
Yes. Both 501(c)(3) nonprofits and non-501(c)(3) nonprofits were included as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations, including small businesses and other for-profit entities, were eligible.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The eligibility section explicitly noted categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander serving institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were explicitly noted among eligible categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were explicitly listed among eligible categories.
Are eligible federal agencies included?
Yes. The eligibility section noted eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions and non-U.S. organizational components were not eligible to apply.
Are foreign components allowed under NIH policy?
Yes. While foreign institutions and non-U.S. organizational components were not eligible to apply, foreign components as defined by NIH policy were allowed.
What is the relationship between the HTC and LungMAP Research Centers (RCs)?
The HTC supplies the human developing lung tissue pipeline by acquiring, processing, and distributing high-quality, well-annotated specimens to LungMAP Research Centers, which then perform molecular assays and analyses used for the atlas.
Where can applicants find the official announcement details?
NIH directed applicants to the official RFA page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-14-007.html.
Who was listed as a contact for access or linking issues?
NIH provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues related to the announcement page.
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